Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | solute carrier family 6 (neurotransmitter transporter, GABA), member 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | solute carrier family 6 (neurotransmitter transporter, GABA), member 1 | 599 aa | 605 aa | 22.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0656 | 1 | 1 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0123 | 0.0218 | 0.0218 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0111 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0656 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0111 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0656 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0111 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0218 | 0.0218 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0111 | 0 | 0.5 |
Onchocerca volvulus | 0.0111 | 0 | 0.5 | |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0123 | 0.0218 | 0.0218 |
Onchocerca volvulus | 0.0111 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0656 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0123 | 0.0218 | 0.0218 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0123 | 0.0218 | 0.0218 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0656 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0218 | 0.0218 |
Onchocerca volvulus | 0.0111 | 0 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0656 | 1 | 1 |
Onchocerca volvulus | 0.0111 | 0 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0111 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0111 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0656 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0656 | 1 | 1 |
Onchocerca volvulus | 0.0111 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0656 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0656 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0656 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0656 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0123 | 0.0218 | 0.0218 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | < 5 % | Binding affinity to mouse GAT1 expressed in HEK293 cells membranes assessed as remaining [2H10]NO711 binding level at 10 uM using LC-ESI-MS/MS analysis by [2H10]NO711 binding inhibition assay | ChEMBL. | 23336362 |
IC50 (binding) | = 6.899 | Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysis | ChEMBL. | 23336362 |
Ki (binding) | = 7.607 | Binding affinity to mouse GAT1 expressed in HEK293 cells membranes using LC-ESI-MS/MS analysis by [2H10]NO711 binding inhibition assay | ChEMBL. | 23336362 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.