Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 14 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0163 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0163 | 1 | 1 |
Onchocerca volvulus | 0.0163 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0163 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0163 | 1 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0163 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0163 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0163 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0163 | 1 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0163 | 1 | 1 |
Onchocerca volvulus | 0.0163 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0163 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0163 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0163 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0163 | 1 | 0.5 |
Onchocerca volvulus | 0.0163 | 1 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.0163 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0163 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0163 | 1 | 0.5 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0152 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0163 | 1 | 1 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0152 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0163 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.007 uM | Inhibition of p38alpha MAP kinase (unknown origin) by ELISA | ChEMBL. | 23270382 |
IC50 (binding) | = 0.042 uM | Inhibition of p38alpha MAP kinase in whole blood (unknown origin) assessed as lipopolysaccharide-stimulated TNF-alpha release by ELISA | ChEMBL. | 23270382 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.