Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 reverse transcriptase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0048 | 0.2617 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0048 | 0.2617 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0048 | 0.2617 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2617 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0048 | 0.2617 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0048 | 0.2617 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0048 | 0.2617 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0048 | 0.2617 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0048 | 0.2617 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0048 | 0.2617 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0048 | 0.2617 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0048 | 0.2617 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0048 | 0.2617 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0048 | 0.2617 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0048 | 0.2617 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0048 | 0.2617 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0048 | 0.2617 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2617 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0048 | 0.2617 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0048 | 0.2617 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2617 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0048 | 0.2617 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0048 | 0.2617 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0048 | 0.2617 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0048 | 0.2617 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0048 | 0.2617 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0048 | 0.2617 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0048 | 0.2617 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0048 | 0.2617 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0048 | 0.2617 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0048 | 0.2617 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0048 | 0.2617 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0048 | 0.2617 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0048 | 0.2617 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0048 | 0.2617 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0048 | 0.2617 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0048 | 0.2617 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0048 | 0.2617 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0048 | 0.2617 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0048 | 0.2617 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0048 | 0.2617 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0048 | 0.2617 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0048 | 0.2617 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2617 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0048 | 0.2617 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0048 | 0.2617 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2617 | 0.5 |
Onchocerca volvulus | 0.0048 | 0.2617 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2617 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2617 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0048 | 0.2617 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0048 | 0.2617 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0048 | 0.2617 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0048 | 0.2617 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2617 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0048 | 0.2617 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0048 | 0.2617 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0048 | 0.2617 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.236 uM | Inhibitory constant against HIV-1 reverse transcriptase | ChEMBL. | 15801860 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.