Detailed information for compound 1746098

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 2180.49 | Formula: C94H154N32O26S
  • H donors: 34 H acceptors: 27 LogP: -11.75 Rotable bonds: 97
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CO)CCCCN)C)CCCNC(=N)N)CCC(=O)N)Cc1ccccc1)CO)C)CCCCN)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]([C@H](O)C)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)N)Cc1ccccc1)CCCNC(=N)N)Cc1c[nH]cn1)CCSC
  • InChi: 1S/C94H154N32O26S/c1-50(2)74(125-72(133)44-107-79(138)67(41-56-42-104-49-110-56)122-83(142)62(29-20-37-106-94(102)103)118-87(146)65(120-78(137)57(98)46-127)39-54-21-9-7-10-22-54)90(149)108-45-73(134)126-75(53(5)130)91(150)109-43-71(132)113-64(32-38-153-6)86(145)116-60(27-15-18-35-97)82(141)115-58(25-13-16-33-95)80(139)112-52(4)77(136)123-68(47-128)89(148)121-66(40-55-23-11-8-12-24-55)88(147)119-63(30-31-70(99)131)85(144)117-61(28-19-36-105-93(100)101)81(140)111-51(3)76(135)114-59(26-14-17-34-96)84(143)124-69(48-129)92(151)152/h7-12,21-24,42,49-53,57-69,74-75,127-130H,13-20,25-41,43-48,95-98H2,1-6H3,(H2,99,131)(H,104,110)(H,107,138)(H,108,149)(H,109,150)(H,111,140)(H,112,139)(H,113,132)(H,114,135)(H,115,141)(H,116,145)(H,117,144)(H,118,146)(H,119,147)(H,120,137)(H,121,148)(H,122,142)(H,123,136)(H,124,143)(H,125,133)(H,126,134)(H,151,152)(H4,100,101,105)(H4,102,103,106)/t51-,52-,53+,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,74-,75-/m0/s1
  • InChiKey: PSEHBXHQOXPLHN-BOQVASPJSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0469 0.4868 0.6897
Loa Loa (eye worm) hypothetical protein 0.0184 0.1748 0.2202
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0187 0.1789 0.2536
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0285 0.286 0.4053
Plasmodium falciparum protein kinase, putative 0.0184 0.1748 0.5
Echinococcus multilocularis FL cytokine receptor 0.0184 0.1748 0.2477
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0184 0.1748 0.5
Echinococcus granulosus protein tyrosine kinase 0.0184 0.1748 0.2334
Schistosoma mansoni hypothetical protein 0.0285 0.286 0.5724
Echinococcus granulosus tyrosine protein kinase Srms 0.0469 0.4868 0.6497
Echinococcus granulosus tyrosine protein kinase Blk 0.0469 0.4868 0.6497
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Schistosoma mansoni biogenic amine receptor 0.004 0.0175 0.0002
Loa Loa (eye worm) hypothetical protein 0.0285 0.286 0.3675
Echinococcus granulosus suppressor of cytokine signaling 6 0.0285 0.286 0.3818
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.0175 0.0248
Loa Loa (eye worm) TK protein kinase 0.0184 0.1748 0.2202
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Loa Loa (eye worm) melatonin receptor type 1A 0.004 0.0175 0.0119
Echinococcus granulosus nmda type glutamate receptor 0.0086 0.0677 0.0903
Schistosoma mansoni adenoreceptor 0.004 0.0175 0.0002
Loa Loa (eye worm) RGC/RGC protein kinase 0.0184 0.1748 0.2202
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0184 0.1748 0.3354
Schistosoma mansoni growth factor receptor-bound protein 0.0285 0.286 0.5724
Echinococcus granulosus tyrosine kinase 0.0469 0.4868 0.6497
Echinococcus granulosus neuropeptide Y receptor 0.004 0.0175 0.0234
Loa Loa (eye worm) hypothetical protein 0.0369 0.3777 0.4888
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Brugia malayi SH2 domain containing protein 0.0285 0.286 0.2761
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.0175 0.0119
Echinococcus granulosus dro:myosuppressin receptor 0.004 0.0175 0.0234
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0175 0.0002
Schistosoma mansoni myosin xvIII 0.004 0.0175 0.0002
Echinococcus granulosus activated cdc42 kinase 1 0.0184 0.1748 0.2334
Onchocerca volvulus 0.0184 0.1748 0.3352
Schistosoma mansoni tensin 0.0285 0.286 0.5724
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0469 0.4868 0.6497
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.004 0.0175 0.0234
Brugia malayi SH2 domain containing protein 0.0285 0.286 0.2761
Brugia malayi Tensin 0.0285 0.286 0.2761
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Echinococcus multilocularis nmda type glutamate receptor 0.0082 0.0637 0.0903
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Brugia malayi hypothetical protein 0.004 0.0175 0.0038
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0187 0.1789 0.2257
Echinococcus multilocularis nmda type glutamate receptor 0.0086 0.0677 0.0959
Echinococcus granulosus activin receptor type 0.0184 0.1748 0.2334
Echinococcus multilocularis epidermal growth factor receptor 0.0184 0.1748 0.2477
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0285 0.286 0.5723
Loa Loa (eye worm) TK/FER protein kinase 0.0469 0.4868 0.6333
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0184 0.1748 0.2334
Loa Loa (eye worm) hypothetical protein 0.0285 0.286 0.3675
Brugia malayi putative neuropeptide receptor NPR1 0.004 0.0175 0.0038
Loa Loa (eye worm) TK/EGFR protein kinase 0.0184 0.1748 0.2202
Echinococcus multilocularis tyrosine protein kinase Abl 0.0469 0.4868 0.6897
Echinococcus granulosus tyrosine protein kinase pr2 0.0184 0.1748 0.2334
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Schistosoma mansoni amine GPCR 0.004 0.0175 0.0002
Brugia malayi hypothetical protein 0.0184 0.1748 0.1633
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0184 0.1748 0.2477
Brugia malayi Tyrosine-protein kinase PR2 0.0184 0.1748 0.1633
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0285 0.286 0.3675
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0285 0.286 0.3675
Brugia malayi Protein kinase domain containing protein 0.0469 0.4868 0.4796
Entamoeba histolytica protein kinase, putative 0.0285 0.286 0.3566
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.004 0.0175 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Brugia malayi Furin-like cysteine rich region family protein 0.0184 0.1748 0.1633
Echinococcus multilocularis activated cdc42 kinase 1 0.0184 0.1748 0.2477
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0285 0.286 0.3818
Echinococcus granulosus expressed conserved protein 0.0285 0.286 0.3818
Loa Loa (eye worm) TK/FER protein kinase 0.0184 0.1748 0.2202
Brugia malayi SH2 domain containing protein 0.0469 0.4868 0.4796
Echinococcus granulosus suppressor of cytokine signaling 7 0.0285 0.286 0.3818
Brugia malayi larval opioid receptor 0.004 0.0175 0.0038
Loa Loa (eye worm) TK/FER protein kinase 0.0184 0.1748 0.2202
Schistosoma mansoni vav2 0.0285 0.286 0.5724
Loa Loa (eye worm) TK/INSR protein kinase 0.0184 0.1748 0.2202
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.1748 1
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0184 0.1748 0.2202
Echinococcus multilocularis neuropeptide FF receptor 2 0.004 0.0175 0.0248
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0184 0.1748 0.2202
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.004 0.0175 0.0002
Echinococcus granulosus neuropeptides capa receptor 0.004 0.0175 0.0234
Brugia malayi hypothetical protein 0.004 0.0175 0.0038
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0184 0.1748 0.2334
Schistosoma mansoni SH2A 0.0285 0.286 0.5724
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0184 0.1748 0.2334
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0184 0.1748 0.2477
Plasmodium falciparum tyrosine kinase-like protein 0.0184 0.1748 0.5
Echinococcus granulosus activated cdc42 kinase 1 0.0184 0.1748 0.2334
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0184 0.1748 0.2202
Echinococcus granulosus growth factor receptor bound protein 2 0.0285 0.286 0.3818
Schistosoma mansoni hypothetical protein 0.0285 0.286 0.5724
Echinococcus multilocularis ephrin type A receptor 4 A 0.0184 0.1748 0.2477
Brugia malayi ephrin receptor 1 precursor 0.0184 0.1748 0.1633
Echinococcus multilocularis neuropeptide receptor 0.004 0.0175 0.0248
Loa Loa (eye worm) hypothetical protein 0.0285 0.286 0.3675
Trichomonas vaginalis protein kinase atn1, putative 0.0184 0.1748 1
Echinococcus granulosus somatostatin receptor 0.004 0.0175 0.0234
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Brugia malayi follicle stimulating hormone receptor 0.004 0.0175 0.0038
Echinococcus multilocularis SH2 motif 0.0285 0.286 0.4053
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.004 0.0175 0.0248
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0184 0.1748 0.3354
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Trichomonas vaginalis STE family protein kinase 0.0184 0.1748 1
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Onchocerca volvulus 0.0184 0.1748 0.3352
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0722 0.7637 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.004 0.0175 0.0234
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.1748 1
Brugia malayi hypothetical protein 0.004 0.0175 0.0038
Echinococcus granulosus neuropeptide FF receptor 2 0.004 0.0175 0.0234
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0285 0.286 0.5724
Echinococcus granulosus tyrosine protein kinase Fyn 0.0469 0.4868 0.6497
Brugia malayi sulfakinin receptor protein 0.004 0.0175 0.0038
Onchocerca volvulus 0.0285 0.286 0.5723
Schistosoma mansoni tyrosine kinase 0.0469 0.4868 1
Brugia malayi G-protein coupled receptor 0.004 0.0175 0.0038
Loa Loa (eye worm) hypothetical protein 0.0184 0.1748 0.2202
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Echinococcus multilocularis tyrosine protein kinase csk 0.0184 0.1748 0.2477
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.0175 0.0119
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0469 0.4868 0.6897
Echinococcus granulosus tensin 0.0285 0.286 0.3818
Loa Loa (eye worm) TK protein kinase 0.0184 0.1748 0.2202
Echinococcus multilocularis tyrosine kinase 0.0469 0.4868 0.6897
Loa Loa (eye worm) SRC-1 0.0469 0.4868 0.6333
Echinococcus granulosus g protein coupled receptor 0.004 0.0175 0.0234
Plasmodium vivax protein kinase, putative 0.0184 0.1748 0.5
Brugia malayi Variant SH3 domain containing protein 0.0285 0.286 0.2761
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Echinococcus granulosus thyrotropin releasing hormone receptor 0.004 0.0175 0.0234
Schistosoma mansoni suppressor of cytokine signaling 0.0285 0.286 0.5724
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0184 0.1748 0.3352
Onchocerca volvulus 0.0285 0.286 0.5723
Loa Loa (eye worm) hypothetical protein 0.0285 0.286 0.3675
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Echinococcus multilocularis tachykinin peptides receptor 99D 0.004 0.0175 0.0248
Echinococcus multilocularis fmrfamide receptor 0.004 0.0175 0.0248
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0175 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0175 0.0248
Echinococcus granulosus SHC transforming protein 3 0.0285 0.286 0.3818
Echinococcus granulosus tyrosine protein kinase ABL1 0.0469 0.4868 0.6497
Echinococcus granulosus protein kinase 0.0184 0.1748 0.2334
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.0175 0.0248
Echinococcus multilocularis NCK adaptor protein 0.0285 0.286 0.4053
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0175 0.0002
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0469 0.4868 0.6897
Loa Loa (eye worm) follicle stimulating hormone receptor 0.004 0.0175 0.0119
Onchocerca volvulus 0.0184 0.1748 0.3352
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.0175 0.0234
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0184 0.1748 0.2334
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Brugia malayi Protein kinase domain containing protein 0.0469 0.4868 0.4796
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Echinococcus multilocularis activin receptor type 0.0184 0.1748 0.2477
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.0175 0.0248
Echinococcus multilocularis serotonin receptor 0.004 0.0175 0.0248
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0187 0.1789 0.2257
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.0175 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0285 0.286 0.5724
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0184 0.1748 0.3354
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0184 0.1748 0.1633
Onchocerca volvulus 0.0469 0.4868 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.004 0.0175 0.0248
Echinococcus granulosus SH2 domain containing protein 7 0.0285 0.286 0.3818
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Brugia malayi Protein kinase domain containing protein 0.0469 0.4868 0.4796
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.004 0.0175 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.1748 0.3354
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0285 0.286 0.5724
Loa Loa (eye worm) RGC/RGC protein kinase 0.0187 0.1789 0.2257
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Echinococcus granulosus tyrosine kinase 0.0187 0.1789 0.2389
Schistosoma mansoni neuropeptide receptor 0.004 0.0175 0.0002
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.1748 0.3354
Echinococcus multilocularis protein tyrosine kinase 0.0184 0.1748 0.2477
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.004 0.0175 0.0248
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Loa Loa (eye worm) hypothetical protein 0.0469 0.4868 0.6333
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Schistosoma mansoni protein kinase 0.0184 0.1748 0.3354
Brugia malayi putative neuropeptide receptor 0.004 0.0175 0.0038
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0285 0.286 0.4053
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0184 0.1748 0.2477
Schistosoma mansoni opsin-like receptor 0.004 0.0175 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Brugia malayi SRC-1 0.0469 0.4868 0.4796
Echinococcus granulosus neuropeptide receptor 0.004 0.0175 0.0234
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.004 0.0175 0.0248
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0175 0.0234
Echinococcus multilocularis SH2 motif 0.0285 0.286 0.4053
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.004 0.0175 0.0038
Loa Loa (eye worm) TK/EPH protein kinase 0.0184 0.1748 0.2202
Schistosoma mansoni protein kinase 0.0184 0.1748 0.3354
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Echinococcus granulosus 7tm_1 domain containing protein 0.004 0.0175 0.0234
Loa Loa (eye worm) TK/FER protein kinase 0.0469 0.4868 0.6333
Loa Loa (eye worm) TK protein kinase 0.0184 0.1748 0.2202
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0184 0.1748 0.2202
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0175 0.0248
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Brugia malayi G protein-coupled receptor 0.004 0.0175 0.0038
Echinococcus granulosus tyrosine protein kinase Src64B 0.0469 0.4868 0.6497
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Schistosoma mansoni tyrosine kinase 0.0469 0.4868 1
Loa Loa (eye worm) hypothetical protein 0.0285 0.286 0.3675
Onchocerca volvulus 0.0184 0.1748 0.3352
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.004 0.0175 0.0248
Loa Loa (eye worm) hypothetical protein 0.0285 0.286 0.3675
Onchocerca volvulus 0.0184 0.1748 0.3352
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0184 0.1748 0.2202
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus granulosus natriuretic peptide receptor 1 0.0184 0.1748 0.2334
Onchocerca volvulus 0.0187 0.1789 0.344
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Schistosoma mansoni tyrosine kinase 0.0469 0.4868 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0285 0.286 0.5724
Giardia lamblia Kinase, NEK 0.0184 0.1748 0.5
Echinococcus granulosus N chimaerin 0.0285 0.286 0.3818
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.004 0.0175 0.0002
Onchocerca volvulus 0.0184 0.1748 0.3352
Brugia malayi bone morphogenetic protein type 1 receptor 0.0184 0.1748 0.1633
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.004 0.0175 0.0234
Brugia malayi Variant SH3 domain containing protein 0.0285 0.286 0.2761
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0184 0.1748 0.1633
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0184 0.1748 0.2477
Schistosoma mansoni opsin-like receptor 0.004 0.0175 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0175 0.0248
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0184 0.1748 0.1633
Loa Loa (eye worm) TK protein kinase 0.0184 0.1748 0.2202
Plasmodium falciparum tyrosine kinase-like protein 0.0184 0.1748 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.004 0.0175 0.0119
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus granulosus kinase suppressor of Ras 1 0.0184 0.1748 0.2334
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Brugia malayi neuropeptide F receptor 0.004 0.0175 0.0038
Schistosoma mansoni hypothetical protein 0.004 0.0175 0.0002
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0184 0.1748 0.2334
Echinococcus multilocularis g protein coupled receptor 0.004 0.0175 0.0248
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0184 0.1748 0.2477
Echinococcus granulosus neuropeptide receptor A26 0.004 0.0175 0.0234
Loa Loa (eye worm) TK/FER protein kinase 0.0184 0.1748 0.2202
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0285 0.286 0.3818
Schistosoma mansoni tensin-related 0.0285 0.286 0.5724
Schistosoma mansoni biogenic amine receptor 0.004 0.0175 0.0002
Onchocerca volvulus 0.0469 0.4868 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Leishmania major C-8 sterol isomerase-like protein 0.0722 0.7637 1
Brugia malayi SH2 domain containing protein 0.0285 0.286 0.2761
Schistosoma mansoni hypothetical protein 0.0184 0.1748 0.3354
Trypanosoma brucei C-8 sterol isomerase, putative 0.0722 0.7637 1
Echinococcus multilocularis protein kinase 0.0184 0.1748 0.2477
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Echinococcus multilocularis growth factor receptor bound protein 2 0.0285 0.286 0.4053
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0184 0.1748 0.2477
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0184 0.1748 0.3354
Echinococcus multilocularis transfer RNA-Thr 0.0184 0.1748 0.2477
Schistosoma mansoni tyrosine kinase 0.0469 0.4868 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0184 0.1748 0.1633
Brugia malayi SH2 domain containing protein 0.0285 0.286 0.2761
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus granulosus receptor type guanylyl cyclase 0.0187 0.1789 0.2389
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0184 0.1748 0.2334
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0175 0.0248
Echinococcus granulosus hypothetical protein 0.0709 0.7492 1
Schistosoma mansoni amine GPCR 0.004 0.0175 0.0002
Echinococcus granulosus tyrosine protein kinase Src42A 0.0469 0.4868 0.6497
Loa Loa (eye worm) TK protein kinase 0.0469 0.4868 0.6333
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0175 0.0234
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.004 0.0175 0.0119
Echinococcus multilocularis tyrosine protein kinase csk 0.0184 0.1748 0.2477
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0285 0.286 0.3675
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0469 0.4868 0.6497
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0184 0.1748 0.2477
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0138 0.0069
Echinococcus multilocularis SH2 motif 0.0285 0.286 0.4053
Loa Loa (eye worm) hypothetical protein 0.0184 0.1748 0.2202
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0184 0.1748 0.2334
Schistosoma mansoni tyrosine kinase 0.0187 0.1789 0.3442
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0469 0.4868 0.6897
Echinococcus multilocularis heat shock protein 70 0.0184 0.1748 0.2477
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.0175 0.0002
Loa Loa (eye worm) TK/Met protein kinase 0.0184 0.1748 0.2202
Echinococcus granulosus g protein coupled receptor 0.004 0.0175 0.0234
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Echinococcus granulosus serotonin receptor 0.004 0.0175 0.0234
Loa Loa (eye worm) hypothetical protein 0.0285 0.286 0.3675
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Brugia malayi Dopamine receptor protein 2 0.004 0.0175 0.0038
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0184 0.1748 0.1633
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus multilocularis serotonin receptor 0.004 0.0175 0.0248
Echinococcus granulosus epidermal growth factor receptor 0.0184 0.1748 0.2334
Schistosoma mansoni tyrosine protein kinase 0.0184 0.1748 0.3354
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0184 0.1748 1
Schistosoma mansoni serine/threonine RGC 0.0184 0.1748 0.3354
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0285 0.286 0.2761
Loa Loa (eye worm) TK/CSK protein kinase 0.0184 0.1748 0.2202
Echinococcus granulosus retinal guanylyl cyclase 2 0.0184 0.1748 0.2334
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.004 0.0175 0.0119
Echinococcus multilocularis orexin receptor type 2 0.004 0.0175 0.0248
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Schistosoma mansoni protein kinase 0.0184 0.1748 0.3354
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus multilocularis SHC transforming protein 3 0.0285 0.286 0.4053
Schistosoma mansoni ephrin receptor 0.0184 0.1748 0.3354
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0469 0.4868 0.6897
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0175 0.0248
Loa Loa (eye worm) TK/ALK protein kinase 0.0184 0.1748 0.2202
Schistosoma mansoni neuropeptide receptor 0.004 0.0175 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.1748 1
Schistosoma mansoni amine GPCR 0.004 0.0175 0.0002
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0184 0.1748 0.2334
Echinococcus granulosus tyrosine protein kinase csk 0.0184 0.1748 0.2334
Echinococcus multilocularis fmrfamide receptor 0.004 0.0175 0.0248
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0184 0.1748 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0184 0.1748 0.1633
Brugia malayi AKH receptor 0.004 0.0175 0.0038
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.004 0.0175 0.0002
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0469 0.4868 1
Toxoplasma gondii STE kinase 0.0184 0.1748 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Echinococcus granulosus neuropeptide receptor 0.004 0.0175 0.0234
Loa Loa (eye worm) hypothetical protein 0.0184 0.1748 0.2202
Echinococcus granulosus nmda type glutamate receptor 0.0082 0.0637 0.0851
Brugia malayi integrin-linked kinase 0.0184 0.1748 0.1633
Echinococcus granulosus insulin receptor 0.0184 0.1748 0.2334
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0184 0.1748 0.5
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0138 0.0184
Loa Loa (eye worm) TK/FER protein kinase 0.0469 0.4868 0.6333
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Echinococcus granulosus tyrosine protein kinase Fyn 0.0469 0.4868 0.6497
Loa Loa (eye worm) TK protein kinase 0.0184 0.1748 0.2202
Brugia malayi Sex muscle abnormal protein 5 0.0285 0.286 0.2761
Echinococcus granulosus SH2 domain containing adapter protein F 0.0285 0.286 0.3818
Echinococcus granulosus tyrosine protein kinase 0.0184 0.1748 0.2334
Echinococcus granulosus glutamate receptor NMDA 0.0078 0.0596 0.0796
Brugia malayi gonadotropin-releasing hormone receptor 2 0.004 0.0175 0.0038
Brugia malayi Variant SH3 domain containing protein 0.0285 0.286 0.2761
Schistosoma mansoni tensin-related 0.0285 0.286 0.5724
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0184 0.1748 0.2334
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0469 0.4868 0.6897
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.0175 0.0119
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0184 0.1748 0.2202
Loa Loa (eye worm) hypothetical protein 0.0184 0.1748 0.2202
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0285 0.286 0.3818
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0175 0.0234
Onchocerca volvulus 0.0285 0.286 0.5723
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0285 0.286 0.3675
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.004 0.0175 0.0234
Echinococcus multilocularis epidermal growth factor receptor 0.0184 0.1748 0.2477
Schistosoma mansoni histamine h1 receptor 0.004 0.0175 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus multilocularis signal transduction protein lnk realted 0.0285 0.286 0.4053
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Brugia malayi ORL1-like opioid receptor 0.004 0.0175 0.0038
Loa Loa (eye worm) hypothetical protein 0.0285 0.286 0.3675
Schistosoma mansoni growth hormone secretagogue receptor 0.004 0.0175 0.0002
Echinococcus multilocularis somatostatin receptor 0.004 0.0175 0.0248
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0175 0.0002
Loa Loa (eye worm) hypothetical protein 0.0184 0.1748 0.2202
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0469 0.4868 1
Echinococcus multilocularis g-protein coupled receptor 0.004 0.0175 0.0248
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0285 0.286 0.4053
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0175 0.0234
Loa Loa (eye worm) hypothetical protein 0.0184 0.1748 0.2202
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus granulosus ephrin type A receptor 4 A 0.0184 0.1748 0.2334
Echinococcus multilocularis G protein coupled receptor 139 0.004 0.0175 0.0248
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0285 0.286 0.3566
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Loa Loa (eye worm) TK protein kinase 0.0184 0.1748 0.2202
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Onchocerca volvulus Tyrosine kinase homolog 0.0184 0.1748 0.3352
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Schistosoma mansoni alpha-1 adrenergic receptor 0.004 0.0175 0.0002
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0175 0.0248
Schistosoma mansoni protein kinase 0.0184 0.1748 0.3354
Echinococcus granulosus tyrosine protein kinase Lyn 0.0469 0.4868 0.6497
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0175 0.0002
Brugia malayi RE15519p 0.004 0.0175 0.0038
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.0175 0.0002
Loa Loa (eye worm) hypothetical protein 0.0285 0.286 0.3675
Loa Loa (eye worm) serine/threonine protein kinase 0.0184 0.1748 0.2202
Echinococcus granulosus tyrosine protein kinase csk 0.0184 0.1748 0.2334
Echinococcus granulosus tyrosine protein kinase shark 0.0469 0.4868 0.6497
Echinococcus granulosus tyrosine protein kinase HCK 0.0184 0.1748 0.2334
Echinococcus granulosus orexin receptor type 2 0.004 0.0175 0.0234
Echinococcus granulosus tyrosine protein kinase Fyn 0.0469 0.4868 0.6497
Echinococcus granulosus neuropeptide Y receptor 0.004 0.0175 0.0234
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0175 0.0234
Schistosoma mansoni hypothetical protein 0.004 0.0175 0.0002
Schistosoma mansoni shc transforming protein 0.0285 0.286 0.5724
Echinococcus multilocularis neuropeptide receptor A26 0.004 0.0175 0.0248
Echinococcus granulosus fmrfamide receptor 0.004 0.0175 0.0234
Echinococcus multilocularis alpha 1A adrenergic receptor 0.004 0.0175 0.0248
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Loa Loa (eye worm) STAT protein 0.0285 0.286 0.3675
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0184 0.1748 0.2477
Loa Loa (eye worm) TK/FER protein kinase 0.0469 0.4868 0.6333
Echinococcus granulosus g-protein coupled receptor 0.004 0.0175 0.0234
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.1748 1
Loa Loa (eye worm) hypothetical protein 0.0285 0.286 0.3675
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0469 0.4868 0.6897
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.0175 0.0119
Brugia malayi SH2 domain containing protein 0.0285 0.286 0.2761
Toxoplasma gondii protein kinase 0.0184 0.1748 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.0175 0.0248
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0469 0.4868 0.6497
Loa Loa (eye worm) TK/FER protein kinase 0.0469 0.4868 0.6333
Loa Loa (eye worm) TK/FER protein kinase 0.0184 0.1748 0.2202
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0175 0.0248
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus multilocularis natriuretic peptide receptor 1 0.0184 0.1748 0.2477
Giardia lamblia Kinase, NEK 0.0184 0.1748 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Brugia malayi hypothetical protein 0.004 0.0175 0.0038
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Echinococcus multilocularis integrin linked protein kinase 0.0184 0.1748 0.2477
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0175 0.0002
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.004 0.0175 0.0119
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0175 0.0234
Brugia malayi Dopamine receptor protein 1 0.004 0.0175 0.0038
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.004 0.0175 0.0248
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.004 0.0175 0.0234
Brugia malayi G protein-coupled receptor F59B2.13 0.004 0.0175 0.0038
Echinococcus multilocularis allatostatin A receptor 0.004 0.0175 0.0248
Onchocerca volvulus 0.0469 0.4868 1
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.0175 0.0002
Echinococcus granulosus SH2 motif 0.0285 0.286 0.3818
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Schistosoma mansoni protein kinase 0.0184 0.1748 0.3354
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0175 0.0234
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.004 0.0175 0.0234
Echinococcus multilocularis tyrosine protein kinase HCK 0.0184 0.1748 0.2477
Brugia malayi RhoGAP domain containing protein 0.0285 0.286 0.2761
Echinococcus multilocularis glutamate receptor NMDA 0.0078 0.0596 0.0845
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0285 0.286 0.4053
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0138 0.0195
Loa Loa (eye worm) TK/FER protein kinase 0.0469 0.4868 0.6333
Brugia malayi hypothetical protein 0.004 0.0175 0.0038
Loa Loa (eye worm) TK/FER protein kinase 0.0469 0.4868 0.6333
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.0175 0.0248
Onchocerca volvulus 0.0184 0.1748 0.3352
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0469 0.4868 0.6497
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0285 0.286 0.3818
Plasmodium falciparum protein kinase, putative 0.0184 0.1748 0.5
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.004 0.0175 0.0002
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0469 0.4868 0.6497
Loa Loa (eye worm) TK/RYK protein kinase 0.0184 0.1748 0.2202
Loa Loa (eye worm) hypothetical protein 0.0184 0.1748 0.2202
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0184 0.1748 0.2202
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0469 0.4868 0.6897
Echinococcus granulosus signal transduction protein lnk realted 0.0285 0.286 0.3818
Echinococcus multilocularis protein kinase 0.0184 0.1748 0.2477
Schistosoma mansoni peptide (allatostatin)-like receptor 0.004 0.0175 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.1748 1
Schistosoma mansoni protein kinase 0.0184 0.1748 0.3354
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0184 0.1748 0.2477
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0469 0.4868 0.6897
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0285 0.286 0.5724
Echinococcus multilocularis tyrosine protein kinase Srms 0.0469 0.4868 0.6897
Loa Loa (eye worm) hypothetical protein 0.0285 0.286 0.3675
Loa Loa (eye worm) TK/ACK protein kinase 0.0184 0.1748 0.2202
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.0175 0.0234
Trichomonas vaginalis protein tyrosine kinase, putative 0.0184 0.1748 1
Echinococcus granulosus raf serine:threonine protein kinase 0.0184 0.1748 0.2334
Schistosoma mansoni tensin 0.0285 0.286 0.5724
Loa Loa (eye worm) TYRA-2 protein 0.004 0.0175 0.0119
Schistosoma mansoni hypothetical protein 0.004 0.0175 0.0002
Echinococcus granulosus retinal guanylyl cyclase 2 0.0184 0.1748 0.2334
Echinococcus multilocularis tyrosine protein kinase csk 0.0184 0.1748 0.2477
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0285 0.286 0.4053
Echinococcus multilocularis tyrosine protein kinase 0.0184 0.1748 0.2477
Schistosoma mansoni glutamate receptor NMDA 0.0102 0.0855 0.145
Schistosoma mansoni tyrosine kinase 0.0469 0.4868 1
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.0175 0.0234
Onchocerca volvulus 0.0469 0.4868 1
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Schistosoma mansoni tensin 0.0285 0.286 0.5724
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0184 0.1748 0.2334
Schistosoma mansoni nck2/grb4 0.0285 0.286 0.5724
Echinococcus multilocularis dro:myosuppressin receptor 0.004 0.0175 0.0248
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0175 0.0248
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0285 0.286 0.3818
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Loa Loa (eye worm) TK/ROR protein kinase 0.0184 0.1748 0.2202
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0722 0.7637 0.7604
Echinococcus granulosus tachykinin peptides receptor 99D 0.004 0.0175 0.0234
Brugia malayi Tachykinin-like peptides receptor 99D 0.004 0.0175 0.0038
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.004 0.0175 0.0248
Brugia malayi Variant SH3 domain containing protein 0.0285 0.286 0.2761
Toxoplasma gondii protein kinase domain-containing protein 0.0184 0.1748 0.5
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0184 0.1748 0.2334
Schistosoma mansoni GTPase activating protein 0.0285 0.286 0.5724
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Giardia lamblia Protein 21.1 0.0184 0.1748 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0175 0.0234
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.004 0.0175 0.0002
Schistosoma mansoni protein kinase 0.0184 0.1748 0.3354
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus multilocularis tyrosine kinase 0.0187 0.1789 0.2536
Echinococcus granulosus tyrosine protein kinase csk 0.0184 0.1748 0.2334
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0175 0.0248
Onchocerca volvulus 0.0285 0.286 0.5723
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.0175 0.0002
Schistosoma mansoni tyrosine kinase 0.0469 0.4868 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0175 0.0002
Loa Loa (eye worm) hypothetical protein 0.0184 0.1748 0.2202
Loa Loa (eye worm) TK/FER protein kinase 0.0469 0.4868 0.6333
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Echinococcus granulosus neuropeptide s receptor 0.004 0.0175 0.0234
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0184 0.1748 1
Loa Loa (eye worm) TK/FER protein kinase 0.0184 0.1748 0.2202
Brugia malayi neuropeptide F receptor 0.004 0.0175 0.0038
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0184 0.1748 0.3354
Echinococcus granulosus SH2 motif 0.0285 0.286 0.3818
Loa Loa (eye worm) hypothetical protein 0.0285 0.286 0.3675
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0184 0.1748 0.2477
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Brugia malayi hypothetical protein 0.0184 0.1748 0.1633
Trichomonas vaginalis AGC family protein kinase 0.0184 0.1748 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0184 0.1748 0.5
Loa Loa (eye worm) TK/DDR protein kinase 0.0184 0.1748 0.2202
Loa Loa (eye worm) TK/FER protein kinase 0.0184 0.1748 0.2202
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0285 0.286 0.3675
Echinococcus multilocularis g protein coupled receptor 0.004 0.0175 0.0248
Brugia malayi protein-tyrosine kinase 0.0469 0.4868 0.4796
Brugia malayi GnHR receptor homolog 0.004 0.0175 0.0038
Schistosoma mansoni growth factor receptor-bound protein 0.0285 0.286 0.5724
Loa Loa (eye worm) hypothetical protein 0.0187 0.1789 0.2257
Entamoeba histolytica SH2 domain containing protein 0.0285 0.286 0.3566
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0285 0.286 0.4053
Schistosoma mansoni opsin-like receptor 0.004 0.0175 0.0002
Echinococcus multilocularis tyrosine protein kinase Blk 0.0469 0.4868 0.6897
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0184 0.1748 0.2477
Loa Loa (eye worm) SH2 domain-containing protein 0.0285 0.286 0.3675
Brugia malayi G-protein coupled receptor 0.004 0.0175 0.0038
Echinococcus granulosus allatostatin A receptor 0.004 0.0175 0.0234
Echinococcus multilocularis c src tyrosine kinase 0.0469 0.4868 0.6897
Schistosoma mansoni protein kinase 0.0187 0.1789 0.3442
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0184 0.1748 0.2202
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0175 0.0002
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0184 0.1748 0.1633
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0184 0.1748 0.2477
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Brugia malayi SH2 domain containing protein 0.0469 0.4868 0.4796
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0469 0.4868 0.6897
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0184 0.1748 1
Brugia malayi hypothetical protein 0.004 0.0175 0.0038
Brugia malayi Guanylyl cyclase protein 23 0.0187 0.1789 0.1675
Brugia malayi SH2 domain containing protein 0.0285 0.286 0.2761
Schistosoma mansoni neuropeptide receptor 0.004 0.0175 0.0002
Loa Loa (eye worm) TK protein kinase 0.0184 0.1748 0.2202
Loa Loa (eye worm) protein kinase domain-containing protein 0.0184 0.1748 0.2202
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus granulosus NCK adaptor protein 0.0285 0.286 0.3818
Loa Loa (eye worm) hypothetical protein 0.0285 0.286 0.3675
Echinococcus granulosus c src tyrosine kinase 0.0469 0.4868 0.6497
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0285 0.286 0.3818
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0175 0.0248
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0184 0.1748 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.0175 0.0248
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Loa Loa (eye worm) TK/FER protein kinase 0.0184 0.1748 0.2202
Schistosoma mansoni biogenic amine receptor 0.004 0.0175 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus multilocularis tensin 0.0285 0.286 0.4053
Loa Loa (eye worm) hypothetical protein 0.0184 0.1748 0.2202
Echinococcus multilocularis 0.0285 0.286 0.4053
Brugia malayi hypothetical protein 0.004 0.0175 0.0038
Schistosoma mansoni protein kinase 0.0184 0.1748 0.3354
Loa Loa (eye worm) hypothetical protein 0.0285 0.286 0.3675
Echinococcus granulosus retinal guanylyl cyclase 2 0.0184 0.1748 0.2334
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.1748 1
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Schistosoma mansoni neuropeptide receptor 0.004 0.0175 0.0002
Schistosoma mansoni signal transduction protein lnk-related 0.0285 0.286 0.5724
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0187 0.1789 0.344
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0285 0.286 0.3675
Echinococcus multilocularis biogenic amine (5HT) receptor 0.004 0.0175 0.0248
Echinococcus granulosus g protein coupled receptor 0.004 0.0175 0.0234
Loa Loa (eye worm) TK protein kinase 0.0184 0.1748 0.2202
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Echinococcus granulosus hypothetical protein 0.0285 0.286 0.3818
Brugia malayi C-terminal src kinase protein 1 0.0184 0.1748 0.1633
Brugia malayi Tyrosine-protein kinase abl-1 0.0469 0.4868 0.4796
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Echinococcus granulosus neuropeptides capa receptor 0.004 0.0175 0.0234
Echinococcus multilocularis SH2 domain containing protein 7 0.0285 0.286 0.4053
Echinococcus multilocularis raf serine:threonine protein kinase 0.0184 0.1748 0.2477
Echinococcus multilocularis sex peptide receptor 0.004 0.0175 0.0248
Loa Loa (eye worm) TK protein kinase 0.0184 0.1748 0.2202
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0285 0.286 0.5723
Echinococcus granulosus epidermal growth factor receptor 0.0184 0.1748 0.2334
Echinococcus multilocularis tyrosine protein kinase shark 0.0469 0.4868 0.6897
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0175 0.0002
Brugia malayi Dopamine receptor 0.004 0.0175 0.0038
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0285 0.286 0.4053
Echinococcus multilocularis insulin receptor 0.0184 0.1748 0.2477
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Loa Loa (eye worm) hypothetical protein 0.0285 0.286 0.3675
Echinococcus multilocularis neuropeptide receptor 0.004 0.0175 0.0248
Loa Loa (eye worm) hypothetical protein 0.0184 0.1748 0.2202
Echinococcus multilocularis kinase suppressor of Ras 1 0.0184 0.1748 0.2477
Brugia malayi Melatonin receptor type 1A 0.004 0.0175 0.0038
Echinococcus multilocularis g protein coupled receptor 0.004 0.0175 0.0248
Echinococcus multilocularis conserved hypothetical protein 0.0669 0.7057 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0184 0.1748 0.2477
Onchocerca volvulus 0.0184 0.1748 0.3352
Giardia lamblia Kinase 0.0184 0.1748 0.5
Brugia malayi Serotonin receptor 0.004 0.0175 0.0038
Echinococcus multilocularis tyrosine protein kinase pr2 0.0184 0.1748 0.2477
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Loa Loa (eye worm) TK/FAK protein kinase 0.0184 0.1748 0.2202
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0469 0.4868 0.6897
Brugia malayi Raf kinase 0.0184 0.1748 0.1633
Plasmodium falciparum protein kinase, putative 0.0184 0.1748 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0184 0.1748 0.2477
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0175 0.0002
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Brugia malayi STAT protein, DNA binding domain containing protein 0.0285 0.286 0.2761
Loa Loa (eye worm) TK/FER protein kinase 0.0469 0.4868 0.6333
Loa Loa (eye worm) TK/ABL protein kinase 0.0469 0.4868 0.6333
Brugia malayi Protein kinase domain containing protein 0.0469 0.4868 0.4796
Schistosoma mansoni amine GPCR 0.004 0.0175 0.0002
Brugia malayi Protein kinase domain containing protein 0.0469 0.4868 0.4796
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Loa Loa (eye worm) TK/FER protein kinase 0.0469 0.4868 0.6333
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Onchocerca volvulus 0.0285 0.286 0.5723
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.004 0.0175 0.0038
Brugia malayi tRNA modification GTPase TrmE family protein 0.0285 0.286 0.2761
Schistosoma mansoni neuropeptide f receptor 76f 0.004 0.0175 0.0002
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0184 0.1748 0.2334
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0184 0.1748 0.2334
Brugia malayi Receptor family ligand binding region containing protein 0.0187 0.1789 0.1675
Onchocerca volvulus 0.0469 0.4868 1
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.1748 0.3354
Schistosoma mansoni tyrosine kinase 0.0187 0.1789 0.3442
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.1748 1
Onchocerca volvulus 0.0285 0.286 0.5723
Brugia malayi hypothetical protein 0.0469 0.4868 0.4796
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0175 0.0234
Schistosoma mansoni suppressor of cytokine signaling 0.0285 0.286 0.5724
Echinococcus granulosus integrin linked protein kinase 0.0184 0.1748 0.2334
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0175 0.0234
Echinococcus granulosus G protein coupled receptor 139 0.004 0.0175 0.0234
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0285 0.286 0.4053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0175 0.0002
Loa Loa (eye worm) hypothetical protein 0.0722 0.7637 1
Brugia malayi cytokine inducible SH2-containing protein 5 0.0285 0.286 0.2761
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.0175 0.0234
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.1748 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0469 0.4868 0.6897
Trichomonas vaginalis TK family protein kinase 0.0184 0.1748 1
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0184 0.1748 0.3354
Brugia malayi SH2 domain containing protein 0.0285 0.286 0.2761
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Schistosoma mansoni protein kinase 0.0184 0.1748 0.3354
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0285 0.286 0.4053
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.1748 0.3354
Loa Loa (eye worm) SH2 domain-containing protein 0.0285 0.286 0.3675
Echinococcus granulosus tyrosine kinase 0.0469 0.4868 0.6497
Schistosoma mansoni adapter molecule crk 0.0285 0.286 0.5724
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Brugia malayi hypothetical protein 0.004 0.0175 0.0038
Brugia malayi Serotonin/octopamine receptor family protein 7 0.004 0.0175 0.0038
Brugia malayi hypothetical protein 0.0285 0.286 0.2761
Schistosoma mansoni ephrin receptor 0.0184 0.1748 0.3354
Echinococcus multilocularis N chimaerin 0.0285 0.286 0.4053
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.004 0.0175 0.0002
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0469 0.4868 0.6897
Schistosoma mansoni protein tyrosine kinase 0.0184 0.1748 0.3354
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0184 0.1748 0.2477
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0184 0.1748 1
Schistosoma mansoni tyrosine kinase 0.0184 0.1748 0.3354
Echinococcus multilocularis neuropeptide s receptor 0.004 0.0175 0.0248
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Schistosoma mansoni amine GPCR 0.004 0.0175 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0175 0.0248
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Schistosoma mansoni hypothetical protein 0.004 0.0175 0.0002
Loa Loa (eye worm) SH2 domain-containing protein 0.0285 0.286 0.3675
Brugia malayi hypothetical protein 0.004 0.0175 0.0038
Brugia malayi hypothetical protein 0.004 0.0175 0.0038
Onchocerca volvulus 0.0469 0.4868 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0175 0.0119
Echinococcus granulosus fibroblast growth factor receptor 4 0.0184 0.1748 0.2334
Echinococcus multilocularis tensin 0.0285 0.286 0.4053
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Brugia malayi Protein kinase domain containing protein 0.0184 0.1748 0.1633
Schistosoma mansoni protein kinase 0.0184 0.1748 0.3354
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0175 0.0002
Echinococcus multilocularis protein KINase family member (kin 25) 0.0184 0.1748 0.2477
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.0175 0.0002
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0184 0.1748 0.1633
Echinococcus granulosus sex peptide receptor 0.004 0.0175 0.0234
Trichomonas vaginalis TKL family protein kinase 0.0184 0.1748 1

Activities

Activity type Activity value Assay description Source Reference
Emax (functional) = 147 % Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization relative to baseline ChEMBL. 17696420

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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