Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0634 | 0.1468 | 0.5 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0634 | 0.1468 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0634 | 0.1468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0634 | 0.1468 | 1 |
Brugia malayi | beta-lactamase | 0.0634 | 0.1468 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0634 | 0.1468 | 0.5 |
Onchocerca volvulus | 0.0634 | 0.1468 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0634 | 0.1468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0634 | 0.1468 | 1 |
Onchocerca volvulus | 0.0634 | 0.1468 | 0.5 | |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0634 | 0.1468 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0634 | 0.1468 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0634 | 0.1468 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0634 | 0.1468 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.008 | 0.0084 | 0.0571 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.008 | 0.0084 | 0.5 |
Trypanosoma brucei | beta lactamase | 0.1245 | 0.2993 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0634 | 0.1468 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0634 | 0.1468 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0634 | 0.1468 | 0.4758 |
Brugia malayi | beta-lactamase family protein | 0.0634 | 0.1468 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0634 | 0.1468 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0634 | 0.1468 | 0.5 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.2595 | 0.6361 | 0.5735 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.008 | 0.0084 | 0.0571 |
Leishmania major | hypothetical protein, conserved | 0.0634 | 0.1468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0634 | 0.1468 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0634 | 0.1468 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0634 | 0.1468 | 1 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.1245 | 0.2993 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0634 | 0.1468 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0634 | 0.1468 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0634 | 0.1468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0634 | 0.1468 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0634 | 0.1468 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0634 | 0.1468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0634 | 0.1468 | 1 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.2595 | 0.6361 | 1 |
Mycobacterium ulcerans | lipoprotein LpqF | 0.1245 | 0.2993 | 0.3117 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.1245 | 0.2993 | 0.1788 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.