Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 reverse transcriptase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.5965 | 0.3316 | 0.3316 |
Schistosoma mansoni | hypothetical protein | 0.5921 | 0.3291 | 0.3291 |
Echinococcus multilocularis | calcium activated potassium channel | 0.5965 | 0.3316 | 0.0074 |
Echinococcus granulosus | maternal embryonic leucine zipper kinase | 1.1976 | 0.6683 | 1 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.003 | 0.003 |
Trichomonas vaginalis | CAMK family protein kinase | 1.7897 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.5965 | 0.3316 | 0.3316 |
Schistosoma mansoni | serine/threonine kinase | 1.7897 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.5965 | 0.3316 | 0.3316 |
Echinococcus multilocularis | maternal embryonic leucine zipper kinase | 1.1976 | 0.6683 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/MELK protein kinase | 1.7897 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.5965 | 0.3316 | 0.0074 |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 0.003 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.5921 | 0.3291 | 0.3291 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.5965 | 0.3316 | 0.0074 |
Schistosoma mansoni | serine/threonine protein kinase | 0.5965 | 0.3316 | 0.3316 |
Schistosoma mansoni | serine/threonine protein kinase | 0.5965 | 0.3316 | 0.3316 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 613 nM | Inhibition of the NNRTI HIV-1 enzyme by 50% using enzyme assay. | ChEMBL. | 11212098 |
IC50 (binding) | = 613 nM | Inhibition of the NNRTI HIV-1 enzyme by 50% using enzyme assay. | ChEMBL. | 11212098 |
IC90 (functional) | = 49 nM | Antiviral activity against HIV-1 in MT-2 (human leukaemia) cells in vitro. | ChEMBL. | 11212098 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.