Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0209 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 1 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0168 | 0.7663 | 0.7663 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.7663 | 0.7663 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0209 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0209 | 1 | 1 |
Echinococcus granulosus | choline O acetyltransferase | 0.0168 | 0.7663 | 0.7663 |
Echinococcus granulosus | acetylcholinesterase | 0.0209 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0035 | 0 | 0.5 |
Brugia malayi | Choline O-acetyltransferase | 0.0168 | 0.7663 | 0.7663 |
Schistosoma mansoni | choline o-acyltransferase | 0.0168 | 0.7663 | 0.7663 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0168 | 0.7663 | 0.7663 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0209 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0168 | 0.7663 | 0.7663 |
Echinococcus multilocularis | acetylcholinesterase | 0.0209 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0209 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0209 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 390 nM | Concentration required to inhibit electrically induced contractions in isolated mouse vas deferens preparation in vitro | ChEMBL. | 7636873 |
IC50 (functional) | = 390 nM | Concentration required to inhibit electrically induced contractions in isolated mouse vas deferens preparation in vitro | ChEMBL. | 7636873 |
Inhibition (binding) | = 42 % | Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes. | ChEMBL. | 7636873 |
Inhibition (binding) | = 42 % | Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes. | ChEMBL. | 7636873 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 7636873 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.