Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0964 | 0.0964 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0181 | 0.0964 | 1 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0181 | 0.0964 | 0.0638 |
Entamoeba histolytica | hypothetical protein | 0.0181 | 0.0964 | 1 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0181 | 0.0964 | 1 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0181 | 0.0964 | 0.0964 |
Brugia malayi | PXA domain containing protein | 0.0181 | 0.0964 | 0.0964 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0186 | 0.1006 | 0.1006 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0181 | 0.0964 | 1 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0181 | 0.0964 | 0.0638 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0181 | 0.0964 | 0.0541 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0964 | 0.0964 |
Schistosoma mansoni | axis inhibition protein axin | 0.0181 | 0.0964 | 0.0541 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0181 | 0.0964 | 0.0964 |
Brugia malayi | Protein kinase domain containing protein | 0.0454 | 0.315 | 0.315 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0181 | 0.0964 | 0.0638 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0181 | 0.0964 | 0.0638 |
Schistosoma mansoni | regulator of G protein signaling | 0.0181 | 0.0964 | 0.0541 |
Loa Loa (eye worm) | RGS-3 protein | 0.0181 | 0.0964 | 0.0964 |
Brugia malayi | hypothetical protein | 0.0181 | 0.0964 | 0.0964 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0186 | 0.1006 | 0.0689 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0181 | 0.0964 | 0.0638 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0181 | 0.0964 | 0.0638 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0181 | 0.0964 | 0.0638 |
Toxoplasma gondii | AGC kinase | 0.006 | 0 | 0.5 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0181 | 0.0964 | 0.0638 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0186 | 0.1006 | 0.0689 |
Giardia lamblia | Kinase, AGC AKT | 0.0088 | 0.0226 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0181 | 0.0964 | 1 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0181 | 0.0964 | 0.0638 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0181 | 0.0964 | 0.0638 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0181 | 0.0964 | 0.0964 |
Brugia malayi | ribosomal protein S6 kinase alpha 3 | 0.0088 | 0.0226 | 0.0226 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0149 | 0.0715 | 0.028 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0181 | 0.0964 | 0.0964 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0964 | 0.0964 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0186 | 0.1006 | 0.0585 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0181 | 0.0964 | 0.0964 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0181 | 0.0964 | 0.0541 |
Echinococcus granulosus | axis inhibition protein axin | 0.0181 | 0.0964 | 0.0638 |
Echinococcus granulosus | axis inhibition protein axin | 0.0181 | 0.0964 | 0.0638 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0181 | 0.0964 | 0.0638 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.0149 | 0.0715 | 0.033 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0181 | 0.0964 | 1 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0181 | 0.0964 | 0.0964 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0088 | 0.0226 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling | 0.0181 | 0.0964 | 0.0541 |
Onchocerca volvulus | 0.0149 | 0.0715 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0964 | 0.0964 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0181 | 0.0964 | 0.0541 |
Entamoeba histolytica | hypothetical protein | 0.0181 | 0.0964 | 1 |
Schistosoma mansoni | regulator of G protein signaling | 0.0181 | 0.0964 | 0.0541 |
Echinococcus granulosus | expressed protein | 0.0181 | 0.0964 | 0.0638 |
Schistosoma mansoni | regulator of G protein signaling | 0.0181 | 0.0964 | 0.0541 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1129 | 0.8556 | 0.8556 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0181 | 0.0964 | 0.0964 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0116 | 0.0447 | 0.0447 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0964 | 0.0964 |
Brugia malayi | hypothetical protein | 0.0181 | 0.0964 | 0.0964 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.006 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0964 | 0.0964 |
Brugia malayi | PXA domain containing protein | 0.0181 | 0.0964 | 0.0964 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.1129 | 0.8556 | 0.8556 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0181 | 0.0964 | 1 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.131 | 1 | 1 |
Schistosoma mansoni | axis inhibition protein axin | 0.0181 | 0.0964 | 0.0541 |
Schistosoma mansoni | serine/threonine protein kinase | 0.131 | 1 | 1 |
Echinococcus multilocularis | rho associated protein kinase | 0.0149 | 0.0715 | 0.033 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0181 | 0.0964 | 0.0638 |
Echinococcus multilocularis | expressed protein | 0.0181 | 0.0964 | 0.0638 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0181 | 0.0964 | 1 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0181 | 0.0964 | 0.0638 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0186 | 0.1006 | 0.0585 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0181 | 0.0964 | 1 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0181 | 0.0964 | 0.0638 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0181 | 0.0964 | 0.0638 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0181 | 0.0964 | 0.0541 |
Schistosoma mansoni | regulator of G protein signaling | 0.0181 | 0.0964 | 0.0541 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.1129 | 0.8556 | 0.8556 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.1129 | 0.8556 | 1 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.0454 | 0.315 | 0.315 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.1129 | 0.8556 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.