TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 650.767 | Formula: C37H42N6O5
H donors: 5 H acceptors: 4 LogP: 3.98 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: OC[C@H](N1C[C@H](C)[C@H](CN(Cc2ccc(cc2)C(=O)Nc2ccccc2N)C)Oc2c(C1=O)cccc2NC(=O)Nc1ccccc1)C
InChi: 1S/C37H42N6O5/c1-24-20-43(25(2)23-44)36(46)29-12-9-15-32(41-37(47)39-28-10-5-4-6-11-28)34(29)48-33(24)22-42(3)21-26-16-18-27(19-17-26)35(45)40-31-14-8-7-13-30(31)38/h4-19,24-25,33,44H,20-23,38H2,1-3H3,(H,40,45)(H2,39,41,47)/t24-,25+,33-/m0/s1
InChiKey: XHCFGJIATIGRMD-DVIHYUSWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0055	0.0329	0.3559
Brugia malayi	G protein-coupled receptor	0.0055	0.0329	0.4451
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0329	0.4263
Loa Loa (eye worm)	G-protein coupled receptor	0.0055	0.0329	0.0329
Brugia malayi	pyruvate dehydrogenase phosphatase regulatory subunit precursor	0.0099	0.0706	0.9548
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0083	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Brugia malayi	neuropeptide F receptor	0.0055	0.0329	0.4451
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0055	0.0329	0.0329
Entamoeba histolytica	anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative	0.0099	0.0706	1
Schistosoma mansoni	amine GPCR	0.0055	0.0329	0.0305
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0055	0.0329	0.4263
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0055	0.0329	0.4263
Onchocerca volvulus		0.0055	0.0329	0.3559
Brugia malayi	larval opioid receptor	0.0055	0.0329	0.4451
Schistosoma mansoni	hypothetical protein	0.0055	0.0329	0.0305
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0055	0.0329	0.4263
Loa Loa (eye worm)	G-protein coupled receptor	0.0055	0.0329	0.0329
Onchocerca volvulus	Pyruvate kinase homolog	0.0037	0.0179	0.1002
Schistosoma mansoni	myosin xvIII	0.0055	0.0329	0.0305
Plasmodium vivax	pyruvate kinase, putative	0.0037	0.0179	0.2277
Schistosoma mansoni	neuropeptide receptor	0.0055	0.0329	0.0305
Entamoeba histolytica	hypothetical protein	0.004	0.0204	0.1951
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.0099	0.0706	0.0536
Brugia malayi	putative neuropeptide receptor NPR1	0.0055	0.0329	0.4451
Brugia malayi	follicle stimulating hormone receptor	0.0055	0.0329	0.4451
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Entamoeba histolytica	hypothetical protein	0.004	0.0204	0.1951
Leishmania major	hypothetical protein, conserved	0.0099	0.0706	1
Schistosoma mansoni	biogenic amine receptor	0.0055	0.0329	0.0305
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0121	0.1635
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Onchocerca volvulus		0.0055	0.0329	0.3559
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0103	0.0739	0.0739
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0055	0.0329	0.4263
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0121	0.0121
Echinococcus multilocularis	fmrfamide receptor	0.0055	0.0329	0.4263
Schistosoma mansoni	hypothetical protein	0.0055	0.0329	0.0305
Echinococcus granulosus	g protein coupled receptor	0.0055	0.0329	0.4263
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0103	0.0739	1
Brugia malayi	hypothetical protein	0.0055	0.0329	0.4451
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0055	0.0329	0.3559
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0121	0.0121
Echinococcus granulosus	neuropeptides capa receptor	0.0055	0.0329	0.4263
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Brugia malayi	hypothetical protein	0.0055	0.0329	0.4451
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0055	0.0329	0.4451
Echinococcus multilocularis	neuropeptide Y receptor	0.0055	0.0329	0.4263
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Echinococcus granulosus	orexin receptor type 2	0.0055	0.0329	0.4263
Echinococcus granulosus	7tm_1 domain containing protein	0.0055	0.0329	0.4263
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Leishmania major	glycerol-3-phosphate dehydrogenase-like protein	0.0099	0.0706	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0055	0.0329	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0329	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Schistosoma mansoni	adenoreceptor	0.0055	0.0329	0.0305
Brugia malayi	sulfakinin receptor protein	0.0055	0.0329	0.4451
Echinococcus granulosus	neuropeptide Y receptor	0.0055	0.0329	0.4263
Brugia malayi	hypothetical protein	0.004	0.0204	0.2766
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0055	0.0329	0.4451
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0204	0.2521
Loa Loa (eye worm)	pyruvate kinase-PB	0.0026	0.0083	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Mycobacterium leprae	Possible thiamine biosynthesis oxidoreductase ThiO	0.0099	0.0706	0.0536
Brugia malayi	G-protein coupled receptor	0.0055	0.0329	0.4451
Loa Loa (eye worm)	TYRA-2 protein	0.0055	0.0329	0.0329
Trichomonas vaginalis	pyruvate kinase, putative	0.0037	0.0179	0.5
Echinococcus granulosus	lamin	0.0031	0.0121	0.1351
Onchocerca volvulus		0.0055	0.0329	0.3559
Echinococcus multilocularis	neuropeptide receptor	0.0055	0.0329	0.4263
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0055	0.0329	0.0305
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0055	0.0329	0.4263
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0055	0.0329	0.4263
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0055	0.0329	0.4451
Brugia malayi	hypothetical protein	0.0055	0.0329	0.4451
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0055	0.0329	0.0305
Echinococcus granulosus	g protein coupled receptor	0.0055	0.0329	0.4263
Echinococcus multilocularis	glycerol 3 phosphate dehydrogenase	0.0099	0.0706	0.9532
Mycobacterium tuberculosis	Probable D-amino acid oxidase Aao	0.1089	0.9155	1
Trypanosoma cruzi	FAD dependent oxidoreductase, putative	0.0099	0.0706	1
Echinococcus granulosus	fmrfamide receptor	0.0055	0.0329	0.4263
Echinococcus granulosus	neuropeptide receptor A26	0.0055	0.0329	0.4263
Onchocerca volvulus	Pyruvate kinase homolog	0.0037	0.0179	0.1002
Schistosoma mansoni	biogenic amine receptor	0.0055	0.0329	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Echinococcus granulosus	somatostatin receptor	0.0055	0.0329	0.4263
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0055	0.0329	0.0329
Schistosoma mansoni	NAD dehydrogenase	0.0099	0.0706	0.0683
Onchocerca volvulus	Dimethylglycine dehydrogenase, mitochondrial homolog	0.0099	0.0706	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0329	0.0305
Loa Loa (eye worm)	pyruvate kinase	0.0037	0.0179	0.0179
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0103	0.0739	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0055	0.0329	0.4263
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0055	0.0329	0.3559
Onchocerca volvulus	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog	0.0099	0.0706	1
Echinococcus multilocularis	orexin receptor type 2	0.0055	0.0329	0.4263
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Schistosoma mansoni	fad oxidoreductase	0.0099	0.0706	0.0683
Brugia malayi	hypothetical protein	0.0055	0.0329	0.4451
Schistosoma mansoni	opsin-like receptor	0.0055	0.0329	0.0305
Echinococcus granulosus	7TM GPCR rhodopsin	0.0055	0.0329	0.4263
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0329	0.4263
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0055	0.0329	0.0305
Loa Loa (eye worm)	pyruvate kinase	0.0037	0.0179	0.0179
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0055	0.0329	0.0305
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0055	0.0329	0.4263
Schistosoma mansoni	neuropeptide F-like receptor	0.0055	0.0329	0.0305
Brugia malayi	G-protein coupled receptor	0.0055	0.0329	0.4451
Mycobacterium ulcerans	thiamine biosynthesis oxidoreductase ThiO	0.0099	0.0706	0.0536
Onchocerca volvulus		0.0055	0.0329	0.3559
Echinococcus granulosus	hypothetical protein	0.0055	0.0329	0.4263
Onchocerca volvulus		0.0055	0.0329	0.3559
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Brugia malayi	dimethylglycine dehydrogenase, mitochondrial precursor, putative	0.0099	0.0706	0.9548
Brugia malayi	Dopamine receptor	0.0055	0.0329	0.4451
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0329	0.4263
Loa Loa (eye worm)	neuropeptide F receptor	0.0055	0.0329	0.0329
Schistosoma mansoni	opsin-like receptor	0.0055	0.0329	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0055	0.0329	0.4263
Schistosoma mansoni	hypothetical protein	0.0055	0.0329	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0055	0.0329	0.0305
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0103	0.0739	0.0717
Echinococcus multilocularis	neuropeptides capa receptor	0.0055	0.0329	0.4263
Brugia malayi	Dopamine receptor protein 2	0.0055	0.0329	0.4451
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0329	0.4263
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0329	0.4263
Schistosoma mansoni	fad oxidoreductase	0.0099	0.0706	0.0683
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0329	0.0305
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0055	0.0329	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0706	0.0706
Loa Loa (eye worm)	pyruvate kinase	0.0037	0.0179	0.0179
Brugia malayi	hypothetical protein	0.0055	0.0329	0.4451
Echinococcus granulosus	tm gpcr rhodopsin	0.0055	0.0329	0.4263
Trichomonas vaginalis	pyruvate kinase, putative	0.0037	0.0179	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0055	0.0329	0.4263
Echinococcus multilocularis	lamin	0.0031	0.0121	0.1351
Echinococcus granulosus	g-protein coupled receptor	0.0055	0.0329	0.4263
Brugia malayi	hypothetical protein	0.0055	0.0329	0.4451
Mycobacterium tuberculosis	Possible thiamine biosynthesis oxidoreductase ThiO	0.0099	0.0706	0.0586
Echinococcus granulosus	pyruvate kinase	0.0037	0.0179	0.2171
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0099	0.0706	1
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0037	0.0179	0.2427
Schistosoma mansoni	growth hormone secretagogue receptor	0.0055	0.0329	0.0305
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0055	0.0329	0.4263
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0329	0.0305
Echinococcus multilocularis	FAD dependent oxidoreductase domain containing protein	0.0099	0.0706	0.9532
Echinococcus multilocularis	neuropeptide s receptor	0.0055	0.0329	0.4263
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0055	0.0329	0.0305
Echinococcus multilocularis	fmrfamide receptor	0.0055	0.0329	0.4263
Echinococcus granulosus	neuropeptide receptor	0.0055	0.0329	0.4263
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0329	0.4263
Echinococcus granulosus	tm gpcr rhodopsin	0.0055	0.0329	0.4263
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0055	0.0329	0.0305
Mycobacterium leprae	Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase)	0.0099	0.0706	0.0536
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0329	0.0305
Entamoeba histolytica	hypothetical protein	0.004	0.0204	0.1951
Schistosoma mansoni	d-amino acid oxidase	0.1189	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0055	0.0329	0.4263
Brugia malayi	Serotonin receptor	0.0055	0.0329	0.4451
Echinococcus granulosus	FAD dependent oxidoreductase domain containing protein	0.0099	0.0706	0.9532
Brugia malayi	G protein-coupled receptor F59B2.13	0.0055	0.0329	0.4451
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0055	0.0329	0.4451
Echinococcus multilocularis	pyruvate kinase	0.0029	0.0112	0.1231
Schistosoma mansoni	neuropeptide receptor	0.0055	0.0329	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0055	0.0329	0.4263
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0329	0.4263
Echinococcus granulosus	neuropeptide s receptor	0.0055	0.0329	0.4263
Loa Loa (eye worm)	glycerol-3-phosphate dehydrogenase	0.0099	0.0706	0.0706
Giardia lamblia	Pyruvate kinase	0.0037	0.0179	0.2277
Brugia malayi	AKH receptor	0.0055	0.0329	0.4451
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0099	0.0706	1
Schistosoma mansoni	amine GPCR	0.0055	0.0329	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0055	0.0329	0.4263
Echinococcus multilocularis	g protein coupled receptor	0.0055	0.0329	0.4263
Schistosoma mansoni	opsin-like receptor	0.0055	0.0329	0.0305
Onchocerca volvulus		0.0055	0.0329	0.3559
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0099	0.0706	1
Brugia malayi	putative neuropeptide receptor	0.0055	0.0329	0.4451
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0055	0.0329	0.0329
Echinococcus granulosus	tm gpcr rhodopsin	0.0055	0.0329	0.4263
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0329	0.4263
Brugia malayi	hypothetical protein	0.0055	0.0329	0.4451
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0055	0.0329	0.4263
Echinococcus granulosus	pyruvate kinase	0.0037	0.0179	0.2171
Brugia malayi	RE15519p	0.0055	0.0329	0.4451
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0055	0.0329	0.4263
Echinococcus granulosus	sex peptide receptor	0.0055	0.0329	0.4263
Brugia malayi	RE18450p	0.0099	0.0706	0.9548
Echinococcus granulosus	g protein coupled receptor	0.0055	0.0329	0.4263
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0037	0.0179	0.2427
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0055	0.0329	0.0305
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0055	0.0329	0.0305
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0121	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Onchocerca volvulus		0.0055	0.0329	0.3559
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0329	0.0305
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0329	0.0305
Echinococcus granulosus	neuropeptide FF receptor 2	0.0055	0.0329	0.4263
Echinococcus granulosus	neuropeptide Y receptor	0.0055	0.0329	0.4263
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0055	0.0329	0.4451
Echinococcus multilocularis	neuropeptide receptor A26	0.0055	0.0329	0.4263
Schistosoma mansoni	glycerol-3-phosphate dehydrogenase	0.0099	0.0706	0.0683
Schistosoma mansoni	histamine h1 receptor	0.0055	0.0329	0.0305
Echinococcus granulosus	biogenic amine 5HT receptor	0.0055	0.0329	0.4263
Schistosoma mansoni	biogenic amine receptor	0.0055	0.0329	0.0305
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0055	0.0329	0.4263
Trypanosoma brucei	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0099	0.0706	1
Echinococcus multilocularis	neuropeptide receptor	0.0055	0.0329	0.4263
Echinococcus multilocularis	pyruvate kinase	0.0037	0.0179	0.2171
Leishmania major	hypothetical protein, conserved	0.0099	0.0706	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0329	0.4263
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0055	0.0329	0.4263
Schistosoma mansoni	hypothetical protein	0.0055	0.0329	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Echinococcus multilocularis	sex peptide receptor	0.0055	0.0329	0.4263
Onchocerca volvulus		0.0055	0.0329	0.3559
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0099	0.0706	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0055	0.0329	0.4263
Schistosoma mansoni	neuropeptide f receptor 76f	0.0055	0.0329	0.0305
Trypanosoma brucei	electron transfer flavoprotein-ubiquinone oxidoreductase, putative	0.0099	0.0706	1
Echinococcus multilocularis	musashi	0.0031	0.0121	0.1351
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0103	0.0739	1
Echinococcus granulosus	serotonin receptor	0.0055	0.0329	0.4263
Echinococcus multilocularis	g-protein coupled receptor	0.0055	0.0329	0.4263
Toxoplasma gondii	pyruvate kinase PyK1	0.0037	0.0179	0.2277
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0055	0.0329	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial	0.0099	0.0706	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Toxoplasma gondii	FAD-dependent glycerol-3-phosphate dehydrogenase	0.0099	0.0706	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0329	0.4263
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase, putative	0.0099	0.0706	1
Onchocerca volvulus		0.0055	0.0329	0.3559
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0055	0.0329	0.4263
Schistosoma mansoni	neuropeptide receptor	0.0055	0.0329	0.0305
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0329	0.4263
Echinococcus multilocularis	g protein coupled receptor	0.0055	0.0329	0.4263
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0103	0.0739	1
Echinococcus granulosus	allatostatin A receptor	0.0055	0.0329	0.4263
Mycobacterium leprae	PROBABLE D-AMINO ACID OXIDASE AAO	0.1189	1	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0055	0.0329	0.0329
Echinococcus granulosus	neuropeptides capa receptor	0.0055	0.0329	0.4263
Giardia lamblia	Glycerol-3-phosphate dehydrogenase	0.0099	0.0706	1
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 20	0.0099	0.0706	1
Onchocerca volvulus		0.0055	0.0329	0.3559
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0055	0.0329	0.4263
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0055	0.0329	0.0305
Echinococcus multilocularis	allatostatin A receptor	0.0055	0.0329	0.4263
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0329	0.4263
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0329	0.4263
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0055	0.0329	0.0305
Brugia malayi	hypothetical protein	0.0055	0.0329	0.4451
Echinococcus granulosus	glycerol 3 phosphate dehydrogenase	0.0099	0.0706	0.9532
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0055	0.0329	0.4263
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0055	0.0329	0.0305
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0103	0.0739	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0055	0.0329	0.4263
Brugia malayi	ORL1-like opioid receptor	0.0055	0.0329	0.4451
Schistosoma mansoni	pyruvate kinase	0.0037	0.0179	0.0156
Brugia malayi	Serotonin receptor	0.0055	0.0329	0.4451
Trypanosoma brucei	FAD dependent oxidoreductase, putative	0.0099	0.0706	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Brugia malayi	cDNA sequence BC016226	0.0099	0.0706	0.9548
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0706	0.0706
Onchocerca volvulus		0.0055	0.0329	0.3559
Echinococcus granulosus	dro:myosuppressin receptor	0.0055	0.0329	0.4263
Schistosoma mansoni	pyruvate kinase	0.0037	0.0179	0.0156
Echinococcus multilocularis	somatostatin receptor	0.0055	0.0329	0.4263
Onchocerca volvulus		0.0055	0.0329	0.3559
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0329	0.4263
Onchocerca volvulus		0.0055	0.0329	0.3559
Echinococcus multilocularis	neuropeptides capa receptor	0.0055	0.0329	0.4263
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0055	0.0329	0.4451
Schistosoma mansoni	neuropeptide F-like receptor	0.0055	0.0329	0.0305
Echinococcus multilocularis	g protein coupled receptor	0.0055	0.0329	0.4263
Onchocerca volvulus	Putative fad oxidoreductase	0.0099	0.0706	1
Schistosoma mansoni	amine GPCR	0.0055	0.0329	0.0305
Brugia malayi	Dopamine receptor protein 1	0.0055	0.0329	0.4451
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Mycobacterium ulcerans	glycerol-3-phosphate dehydrogenase GlpD2	0.0099	0.0706	0.0536
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.1189	1	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Echinococcus granulosus	neuropeptide receptor	0.0055	0.0329	0.4263
Schistosoma mansoni	neuropeptide receptor	0.0055	0.0329	0.0305
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0204	0.0181
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0055	0.0329	0.0329
Entamoeba histolytica	hypothetical protein	0.004	0.0204	0.1951
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0103	0.0739	0.0717
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0329	0.4263
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Brugia malayi	hypothetical protein	0.0055	0.0329	0.4451
Onchocerca volvulus		0.0055	0.0329	0.3559
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0055	0.0329	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0055	0.0329	0.4263
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0055	0.0329	0.4263
Plasmodium falciparum	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.0099	0.0706	1
Onchocerca volvulus	Pyruvate kinase homolog	0.0037	0.0179	0.1002
Brugia malayi	GnHR receptor homolog	0.0055	0.0329	0.4451
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0055	0.0329	0.4263
Echinococcus multilocularis	lamin dm0	0.0031	0.0121	0.1351
Schistosoma mansoni	ATP:guanidino kinase (Smc74)	0.0099	0.0706	0.0683
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Onchocerca volvulus		0.0055	0.0329	0.3559
Plasmodium vivax	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.0099	0.0706	1
Brugia malayi	Melatonin receptor type 1A	0.0055	0.0329	0.4451
Schistosoma mansoni	lamin	0.0031	0.0121	0.0097
Toxoplasma gondii	hypothetical protein	0.0099	0.0706	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0055	0.0329	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0706	0.0706
Echinococcus multilocularis	G protein coupled receptor 139	0.0055	0.0329	0.4263
Echinococcus multilocularis	pyruvate kinase	0.0037	0.0179	0.2171
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0103	0.0739	0.0717
Loa Loa (eye worm)	hypothetical protein	0.003	0.0116	0.0116
Plasmodium falciparum	pyruvate kinase	0.0037	0.0179	0.2277
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0329	0.0305
Echinococcus granulosus	lamin dm0	0.0031	0.0121	0.1351
Echinococcus granulosus	G protein coupled receptor 139	0.0055	0.0329	0.4263
Brugia malayi	intermediate filament protein	0.0031	0.0121	0.1635
Schistosoma mansoni	hypothetical protein	0.004	0.0204	0.0181
Chlamydia trachomatis	D-amino acid dehydrogenase	0.0099	0.0706	1
Entamoeba histolytica	NAD(FAD)-dependent dehydrogenase, putative	0.0099	0.0706	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0055	0.0329	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0179	0.0179
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0329	0.0305
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0055	0.0329	0.4263
Mycobacterium ulcerans	glycerol-3-phosphate dehydrogenase	0.0099	0.0706	0.0536
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0099	0.0706	1
Brugia malayi	neuropeptide F receptor	0.0055	0.0329	0.4451
Schistosoma mansoni	lamin	0.0031	0.0121	0.0097
Echinococcus multilocularis	serotonin receptor	0.0055	0.0329	0.4263
Echinococcus multilocularis	serotonin receptor	0.0055	0.0329	0.4263
Echinococcus multilocularis	dro:myosuppressin receptor	0.0055	0.0329	0.4263
Schistosoma mansoni	amine GPCR	0.0055	0.0329	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0204	0.2521
Schistosoma mansoni	amine GPCR	0.0055	0.0329	0.0305
Echinococcus granulosus	intermediate filament protein	0.0031	0.0121	0.1351
Brugia malayi	hypothetical protein	0.0055	0.0329	0.4451
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0329	0.0329
Onchocerca volvulus		0.0055	0.0329	0.3559

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2361177

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1749786