Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate NMDA receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | hypothetical protein | 0.0268 | 0.0223 | 0.5 |
Echinococcus granulosus | sodium:potassium:calcium exchanger 6 | 0.0268 | 0.0223 | 0.0223 |
Loa Loa (eye worm) | hypothetical protein | 0.4254 | 0.3982 | 0.3845 |
Toxoplasma gondii | manganese resistance 1 protein, putative | 0.0268 | 0.0223 | 0.5 |
Echinococcus granulosus | sodium:potassium:calcium exchanger | 0.0268 | 0.0223 | 0.0223 |
Schistosoma mansoni | sodium/calcium exchanger | 1.0635 | 1 | 1 |
Plasmodium falciparum | cation/H+ antiporter | 0.0268 | 0.0223 | 0.5 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger 6 | 0.0268 | 0.0223 | 0.0223 |
Mycobacterium tuberculosis | Probable ionic transporter integral membrane protein ChaA | 0.0268 | 0.0223 | 0.5 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger | 0.0268 | 0.0223 | 0.0223 |
Entamoeba histolytica | sodium/calcium exchanger protein, putative | 0.0268 | 0.0223 | 0.5 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.1876 | 0.1739 | 1 |
Brugia malayi | Sodium/calcium exchanger protein | 0.4254 | 0.3982 | 1 |
Plasmodium vivax | cation/H+ antiporter, putative | 0.0268 | 0.0223 | 0.5 |
Echinococcus multilocularis | sodium calcium exchanger | 1.0635 | 1 | 1 |
Mycobacterium leprae | Probable ionic transporter integral membrane protein ChaA | 0.0268 | 0.0223 | 0.5 |
Loa Loa (eye worm) | solute carrier family 8 | 1.0635 | 1 | 1 |
Onchocerca volvulus | Sodium\/potassium\/calcium exchanger | 0.0268 | 0.0223 | 0.5 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.1876 | 0.1739 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4 nM | In vitro inhibition of glutamate induced neuronal death in primary cultures of rat hippocampal neurons. | ChEMBL. | 7636876 |
IC50 (functional) | = 4 nM | In vitro inhibition of glutamate induced neuronal death in primary cultures of rat hippocampal neurons. | ChEMBL. | 7636876 |
IC50 (binding) | = 2700 nM | In vitro binding affinity against Alpha-1 adrenergic receptor using [3H]-prazosin as radioligand | ChEMBL. | 7636876 |
IC50 (binding) | = 2700 nM | In vitro binding affinity against Alpha-1 adrenergic receptor using [3H]-prazosin as radioligand | ChEMBL. | 7636876 |
Selectivity ratio (binding) | = 675 | Selectivity between protection against glutamate-induced neuronal damage and alpha 1 adrenergic affinity | ChEMBL. | 7636876 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.