TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 524.738 | Formula: C31H48N4O3
H donors: 1 H acceptors: 3 LogP: 3.72 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: CN(CCCNC(=O)CC1CC(=C(N(C1=O)Cc1ccc(cc1)C(C)(C)C)C)C(=O)N1CCCCCC1)C
InChi: 1S/C31H48N4O3/c1-23-27(30(38)34-18-9-7-8-10-19-34)20-25(21-28(36)32-16-11-17-33(5)6)29(37)35(23)22-24-12-14-26(15-13-24)31(2,3)4/h12-15,25H,7-11,16-22H2,1-6H3,(H,32,36)
InChiKey: BVVUHKZAFWBCRR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0212	0.1642	0.3249
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0528	0.5054	0.4965
Trichomonas vaginalis	conserved hypothetical protein	0.0212	0.1642	0.5
Loa Loa (eye worm)	hypothetical protein	0.0212	0.1642	0.3249
Trichomonas vaginalis	protein kinase atn1, putative	0.0212	0.1642	0.5
Echinococcus multilocularis	tensin	0.0315	0.2757	0.2626
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Plasmodium falciparum	protein kinase, putative	0.0212	0.1642	0.5
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0212	0.1642	0.1491
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Trichomonas vaginalis	conserved hypothetical protein	0.0212	0.1642	0.5
Loa Loa (eye worm)	hypothetical protein	0.0212	0.1642	0.3249
Brugia malayi	Tyrosine-protein kinase PR2	0.0212	0.1642	0.3249
Toxoplasma gondii	STE kinase	0.0212	0.1642	0.5
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0212	0.1642	0.3004
Echinococcus granulosus	natriuretic peptide receptor 1	0.0212	0.1642	0.3004
Brugia malayi	SH2 domain containing protein	0.0528	0.5054	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0212	0.1642	0.1491
Onchocerca volvulus		0.0528	0.5054	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0315	0.2757	0.5455
Echinococcus granulosus	growth factor receptor bound protein 2	0.0315	0.2757	0.5289
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0212	0.1642	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0212	0.1642	0.3249
Schistosoma mansoni	protein tyrosine kinase	0.0212	0.1642	0.3004
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0528	0.5054	0.4965
Echinococcus granulosus	tyrosine protein kinase csk	0.0212	0.1642	0.3004
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0212	0.1642	0.1491
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Schistosoma mansoni	shc transforming protein	0.0315	0.2757	0.5289
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Brugia malayi	Tensin	0.0315	0.2757	0.5455
Echinococcus granulosus	tyrosine protein kinase HCK	0.0212	0.1642	0.3004
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0528	0.5054	0.4965
Brugia malayi	protein-tyrosine kinase	0.0528	0.5054	1
Echinococcus multilocularis	tyrosine protein kinase	0.0212	0.1642	0.1491
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0212	0.1642	0.3004
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0212	0.1642	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0528	0.5054	1
Loa Loa (eye worm)	hypothetical protein	0.0315	0.2757	0.5455
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Schistosoma mansoni	vav2	0.0315	0.2757	0.5289
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0315	0.2757	0.5455
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0212	0.1642	0.3249
Schistosoma mansoni	protein kinase	0.0212	0.1642	0.3004
Brugia malayi	SRC-1	0.0528	0.5054	1
Echinococcus multilocularis	FL cytokine receptor	0.0212	0.1642	0.1491
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Onchocerca volvulus		0.0315	0.2757	0.3267
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Schistosoma mansoni	tyrosine kinase	0.0528	0.5054	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0528	0.5054	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0212	0.1642	0.5
Schistosoma mansoni	tensin-related	0.0315	0.2757	0.5289
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0315	0.2757	0.5289
Loa Loa (eye worm)	TK/FER protein kinase	0.0212	0.1642	0.3249
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0528	0.5054	1
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0212	0.1642	0.5
Echinococcus multilocularis	SH2 motif	0.0315	0.2757	0.2626
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0528	0.5054	1
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0315	0.2757	0.5289
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0212	0.1642	0.3249
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0315	0.2757	0.5289
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0315	0.2757	0.5289
Echinococcus granulosus	tyrosine protein kinase csk	0.0212	0.1642	0.3004
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0212	0.1642	0.3004
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0315	0.2757	0.2626
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0212	0.1642	0.3004
Schistosoma mansoni	protein kinase	0.0212	0.1642	0.3004
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0212	0.1642	0.5
Echinococcus granulosus	tyrosine protein kinase pr2	0.0212	0.1642	0.3004
Schistosoma mansoni	serine/threonine protein kinase	0.0212	0.1642	0.3004
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0315	0.2757	0.2626
Echinococcus multilocularis	tensin	0.0315	0.2757	0.2626
Schistosoma mansoni	protein kinase	0.0212	0.1642	0.3004
Schistosoma mansoni	nck2/grb4	0.0315	0.2757	0.5289
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0212	0.1642	0.3249
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0212	0.1642	0.3249
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0212	0.1642	0.3004
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0212	0.1642	0.3249
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0212	0.1642	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0315	0.2757	0.5455
Trypanosoma cruzi	protein kinase, putative	0.0212	0.1642	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0315	0.2757	0.5455
Onchocerca volvulus		0.0528	0.5054	1
Schistosoma mansoni	ephrin receptor	0.0212	0.1642	0.3004
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0315	0.2757	0.5289
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0528	0.5054	0.4965
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0212	0.1642	0.3249
Brugia malayi	Variant SH3 domain containing protein	0.0315	0.2757	0.5455
Schistosoma mansoni	protein kinase	0.0212	0.1642	0.3004
Echinococcus granulosus	raf serine:threonine protein kinase	0.0212	0.1642	0.3004
Brugia malayi	SH2 domain containing protein	0.0315	0.2757	0.5455
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0212	0.1642	0.3004
Loa Loa (eye worm)	hypothetical protein	0.0315	0.2757	0.5455
Loa Loa (eye worm)	SH2 domain-containing protein	0.0315	0.2757	0.5455
Echinococcus granulosus	SH2 domain containing protein 7	0.0315	0.2757	0.5289
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0212	0.1642	0.1491
Brugia malayi	Raf kinase	0.0212	0.1642	0.3249
Loa Loa (eye worm)	TK protein kinase	0.0212	0.1642	0.3249
Brugia malayi	hypothetical protein	0.0528	0.5054	1
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0212	0.1642	0.3004
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0315	0.2757	0.5289
Onchocerca volvulus		0.0315	0.2757	0.3267
Loa Loa (eye worm)	TK/FER protein kinase	0.0212	0.1642	0.3249
Loa Loa (eye worm)	hypothetical protein	0.0212	0.1642	0.3249
Loa Loa (eye worm)	hypothetical protein	0.0212	0.1642	0.3249
Brugia malayi	SH2 domain containing protein	0.0315	0.2757	0.5455
Schistosoma mansoni	protein kinase	0.0212	0.1642	0.3004
Schistosoma mansoni	signal transduction protein lnk-related	0.0315	0.2757	0.5289
Schistosoma mansoni	GTPase activating protein	0.0315	0.2757	0.5289
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0528	0.5054	1
Brugia malayi	hypothetical protein	0.0212	0.1642	0.3249
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Brugia malayi	Protein kinase domain containing protein	0.0528	0.5054	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0212	0.1642	0.3249
Schistosoma mansoni	hypothetical protein	0.0315	0.2757	0.5289
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0212	0.1642	0.3004
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0212	0.1642	0.3004
Brugia malayi	Protein kinase domain containing protein	0.0528	0.5054	1
Schistosoma mansoni	serine/threonine RGC	0.0212	0.1642	0.3004
Loa Loa (eye worm)	TK/FER protein kinase	0.0528	0.5054	1
Schistosoma mansoni	tensin	0.0315	0.2757	0.5289
Loa Loa (eye worm)	RNA binding protein	0.0077	0.0177	0.0351
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Giardia lamblia	Kinase	0.0212	0.1642	0.5
Schistosoma mansoni	protein kinase	0.0212	0.1642	0.3004
Echinococcus multilocularis	N chimaerin	0.0315	0.2757	0.2626
Loa Loa (eye worm)	hypothetical protein	0.0315	0.2757	0.5455
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0315	0.2757	0.5455
Echinococcus multilocularis	activin receptor type	0.0212	0.1642	0.1491
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0212	0.1642	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0528	0.5054	0.4965
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Echinococcus granulosus	kinase suppressor of Ras 1	0.0212	0.1642	0.3004
Loa Loa (eye worm)	hypothetical protein	0.0315	0.2757	0.5455
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0212	0.1642	0.3249
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0212	0.1642	0.1491
Loa Loa (eye worm)	TK/FER protein kinase	0.0212	0.1642	0.3249
Brugia malayi	ephrin receptor 1 precursor	0.0212	0.1642	0.3249
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0212	0.1642	0.3249
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0315	0.2757	0.5289
Trichomonas vaginalis	STE family protein kinase	0.0212	0.1642	0.5
Schistosoma mansoni	ephrin receptor	0.0212	0.1642	0.3004
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0315	0.2757	0.5289
Loa Loa (eye worm)	TK/FER protein kinase	0.0528	0.5054	1
Brugia malayi	RNA recognition motif domain containing protein	0.0077	0.0177	0.0351
Echinococcus granulosus	tensin	0.0315	0.2757	0.5289
Onchocerca volvulus		0.0315	0.2757	0.3267
Onchocerca volvulus		0.0528	0.5054	1
Giardia lamblia	Kinase, NEK	0.0212	0.1642	0.5
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0212	0.1642	0.1491
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0212	0.1642	0.3249
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Echinococcus multilocularis		0.0315	0.2757	0.2626
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Loa Loa (eye worm)	TK/FER protein kinase	0.0528	0.5054	1
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0528	0.5054	0.4965
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Loa Loa (eye worm)	TK/DDR protein kinase	0.0212	0.1642	0.3249
Loa Loa (eye worm)	TAR-binding protein	0.0077	0.0177	0.0351
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Echinococcus granulosus	receptor type guanylyl cyclase	0.0212	0.1642	0.3004
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0528	0.5054	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0212	0.1642	0.3004
Echinococcus granulosus	protein kinase	0.0212	0.1642	0.3004
Echinococcus multilocularis	protein tyrosine kinase	0.0212	0.1642	0.1491
Loa Loa (eye worm)	hypothetical protein	0.0212	0.1642	0.3249
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0212	0.1642	0.5
Schistosoma mansoni	tensin	0.0315	0.2757	0.5289
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0212	0.1642	0.1491
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Schistosoma mansoni	protein kinase	0.0212	0.1642	0.3004
Loa Loa (eye worm)	TK protein kinase	0.0212	0.1642	0.3249
Schistosoma mansoni	tyrosine protein kinase	0.0212	0.1642	0.3004
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0212	0.1642	0.3004
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Schistosoma mansoni	protein kinase	0.0212	0.1642	0.3004
Schistosoma mansoni	serine/threonine protein kinase	0.0212	0.1642	0.3004
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0315	0.2757	0.5455
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Brugia malayi	RNA binding protein	0.0077	0.0177	0.0351
Schistosoma mansoni	tyrosine kinase	0.0528	0.5054	1
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0212	0.1642	0.1491
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Loa Loa (eye worm)	TK/Met protein kinase	0.0212	0.1642	0.3249
Loa Loa (eye worm)	hypothetical protein	0.0315	0.2757	0.5455
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Plasmodium falciparum	tyrosine kinase-like protein	0.0212	0.1642	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0212	0.1642	0.3004
Echinococcus multilocularis	tyrosine kinase	0.0528	0.5054	0.4965
Schistosoma mansoni	hypothetical protein	0.0315	0.2757	0.5289
Toxoplasma gondii	protein kinase	0.0212	0.1642	0.5
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0315	0.2757	0.2626
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Schistosoma mansoni	tyrosine kinase	0.0528	0.5054	1
Echinococcus granulosus	NCK adaptor protein	0.0315	0.2757	0.5289
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0212	0.1642	0.1491
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0212	0.1642	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0212	0.1642	0.5
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Echinococcus multilocularis	signal transduction protein lnk realted	0.0315	0.2757	0.2626
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0528	0.5054	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0212	0.1642	0.3004
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Echinococcus granulosus	activin receptor type	0.0212	0.1642	0.3004
Brugia malayi	C-terminal src kinase protein 1	0.0212	0.1642	0.3249
Echinococcus multilocularis	NCK adaptor protein	0.0315	0.2757	0.2626
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0212	0.1642	0.3004
Loa Loa (eye worm)	TK/FER protein kinase	0.0528	0.5054	1
Onchocerca volvulus		0.0528	0.5054	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0212	0.1642	0.3249
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Brugia malayi	SH2 domain containing protein	0.0315	0.2757	0.5455
Loa Loa (eye worm)	hypothetical protein	0.0315	0.2757	0.5455
Plasmodium falciparum	protein kinase, putative	0.0212	0.1642	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0315	0.2757	0.2626
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0528	0.5054	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0528	0.5054	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0212	0.1642	0.3004
Echinococcus granulosus	insulin receptor	0.0212	0.1642	0.3004
Schistosoma mansoni	serine/threonine protein kinase	0.0212	0.1642	0.3004
Loa Loa (eye worm)	TK/FER protein kinase	0.0212	0.1642	0.3249
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0315	0.2757	0.5289
Leishmania major	hypothetical protein, conserved	0.0212	0.1642	0.5
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Plasmodium vivax	protein kinase, putative	0.0212	0.1642	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Schistosoma mansoni	hypothetical protein	0.0212	0.1642	0.3004
Loa Loa (eye worm)	hypothetical protein	0.0212	0.1642	0.3249
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0315	0.2757	0.3267
Echinococcus multilocularis	tyrosine protein kinase csk	0.0212	0.1642	0.1491
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0315	0.2757	0.5289
Echinococcus granulosus	tyrosine protein kinase csk	0.0212	0.1642	0.3004
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0315	0.2757	0.2626
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0528	0.5054	0.4965
Echinococcus multilocularis	heat shock protein 70	0.0212	0.1642	0.1491
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Trypanosoma cruzi	protein kinase, putative	0.0212	0.1642	0.5
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Schistosoma mansoni	tyrosine kinase	0.0528	0.5054	1
Echinococcus granulosus	signal transduction protein lnk realted	0.0315	0.2757	0.5289
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0528	0.5054	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0212	0.1642	0.3004
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0528	0.5054	0.4965
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0212	0.1642	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0212	0.1642	0.3004
Schistosoma mansoni	adapter molecule crk	0.0315	0.2757	0.5289
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0528	0.5054	0.4965
Echinococcus multilocularis	SH2 motif	0.0315	0.2757	0.2626
Echinococcus multilocularis	activated cdc42 kinase 1	0.0212	0.1642	0.1491
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Schistosoma mansoni	tensin-related	0.0315	0.2757	0.5289
Echinococcus granulosus	hypothetical protein	0.0315	0.2757	0.5289
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0212	0.1642	0.3249
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Loa Loa (eye worm)	hypothetical protein	0.0528	0.5054	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0212	0.1642	0.3249
Toxoplasma gondii	protein kinase domain-containing protein	0.0212	0.1642	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0212	0.1642	0.3249
Schistosoma mansoni	SH2A	0.0315	0.2757	0.5289
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0212	0.1642	0.3004
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0212	0.1642	0.1491
Plasmodium falciparum	tyrosine kinase-like protein	0.0212	0.1642	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0528	0.5054	1
Echinococcus multilocularis	tyrosine kinase	0.0212	0.1642	0.1491
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0528	0.5054	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.0212	0.1642	0.3249
Brugia malayi	integrin-linked kinase	0.0212	0.1642	0.3249
Echinococcus granulosus	tyrosine kinase	0.0212	0.1642	0.3004
Echinococcus granulosus	N chimaerin	0.0315	0.2757	0.5289
Echinococcus granulosus	epidermal growth factor receptor	0.0212	0.1642	0.3004
Giardia lamblia	Protein 21.1	0.0212	0.1642	0.5
Loa Loa (eye worm)	hypothetical protein	0.0315	0.2757	0.5455
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0315	0.2757	0.5289
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0212	0.1642	0.3249
Loa Loa (eye worm)	hypothetical protein	0.0315	0.2757	0.5455
Loa Loa (eye worm)	TK/RYK protein kinase	0.0212	0.1642	0.3249
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0315	0.2757	0.5455
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0212	0.1642	0.1491
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0212	0.1642	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0528	0.5054	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0528	0.5054	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0528	0.5054	0.4965
Entamoeba histolytica	SH2 domain containing protein	0.0315	0.2757	0.3267
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0528	0.5054	0.4965
Giardia lamblia	Kinase, NEK	0.0212	0.1642	0.5
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0212	0.1642	0.1491
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0212	0.1642	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0212	0.1642	0.5
Loa Loa (eye worm)	hypothetical protein	0.0315	0.2757	0.5455
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0212	0.1642	0.3249
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0315	0.2757	0.5455
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0212	0.1642	0.1491
Plasmodium falciparum	protein kinase, putative	0.0212	0.1642	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0528	0.5054	0.4965
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0212	0.1642	0.1491
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0212	0.1642	0.3004
Loa Loa (eye worm)	TK protein kinase	0.0212	0.1642	0.3249
Loa Loa (eye worm)	hypothetical protein	0.0212	0.1642	0.3249
Echinococcus multilocularis	c src tyrosine kinase	0.0528	0.5054	0.4965
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0212	0.1642	0.3249
Schistosoma mansoni	suppressor of cytokine signaling	0.0315	0.2757	0.5289
Brugia malayi	hypothetical protein	0.0315	0.2757	0.5455
Schistosoma mansoni	serine/threonine protein kinase	0.0212	0.1642	0.3004
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0315	0.2757	0.3267
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0212	0.1642	0.3249
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Schistosoma mansoni	tyrosine kinase	0.0528	0.5054	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0528	0.5054	1
Schistosoma mansoni	tensin	0.0315	0.2757	0.5289
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0315	0.2757	0.5289
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0528	0.5054	0.4965
Echinococcus multilocularis	tyrosine protein kinase csk	0.0212	0.1642	0.1491
Loa Loa (eye worm)	TK protein kinase	0.0212	0.1642	0.3249
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0212	0.1642	0.3249
Schistosoma mansoni	protein kinase	0.0212	0.1642	0.3004
Loa Loa (eye worm)	hypothetical protein	0.0212	0.1642	0.3249
Brugia malayi	TAR-binding protein	0.0077	0.0177	0.0351
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0212	0.1642	0.1491
Loa Loa (eye worm)	hypothetical protein	0.0212	0.1642	0.3249
Trypanosoma brucei	protein kinase, putative	0.0212	0.1642	0.5
Loa Loa (eye worm)	TK protein kinase	0.0528	0.5054	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.0212	0.1642	0.3249
Trichomonas vaginalis	conserved hypothetical protein	0.0212	0.1642	0.5
Loa Loa (eye worm)	hypothetical protein	0.0212	0.1642	0.3249
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Echinococcus granulosus	expressed conserved protein	0.0315	0.2757	0.5289
Loa Loa (eye worm)	hypothetical protein	0.0212	0.1642	0.3249
Onchocerca volvulus		0.0528	0.5054	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0315	0.2757	0.5455
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0315	0.2757	0.5455
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0528	0.5054	0.4965
Loa Loa (eye worm)	hypothetical protein	0.0315	0.2757	0.5455
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0315	0.2757	0.5455
Echinococcus granulosus	SH2 motif	0.0315	0.2757	0.5289
Schistosoma mansoni	tyrosine kinase	0.0528	0.5054	1
Leishmania major	protein kinase, putative	0.0212	0.1642	0.5
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Echinococcus granulosus	tyrosine kinase	0.0528	0.5054	1
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0528	0.5054	0.4965
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0212	0.1642	0.3004
Echinococcus multilocularis	protein kinase	0.0212	0.1642	0.1491
Echinococcus granulosus	tyrosine protein kinase	0.0212	0.1642	0.3004
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Echinococcus multilocularis	protein kinase	0.0212	0.1642	0.1491
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0315	0.2757	0.5455
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0212	0.1642	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Brugia malayi	Variant SH3 domain containing protein	0.0315	0.2757	0.5455
Onchocerca volvulus		0.0315	0.2757	0.3267
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0212	0.1642	0.3004
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0528	0.5054	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0315	0.2757	0.5289
Brugia malayi	hypothetical protein	0.0212	0.1642	0.3249
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Echinococcus multilocularis	SH2 domain containing protein 7	0.0315	0.2757	0.2626
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0212	0.1642	0.3249
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0212	0.1642	0.3004
Echinococcus multilocularis	tyrosine protein kinase shark	0.0528	0.5054	0.4965
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0077	0.0177	0.0351
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0212	0.1642	0.1491
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0212	0.1642	0.1491
Loa Loa (eye worm)	TK protein kinase	0.0212	0.1642	0.3249
Loa Loa (eye worm)	hypothetical protein	0.0315	0.2757	0.5455
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0528	0.5054	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0315	0.2757	0.2626
Trichomonas vaginalis	TK family protein kinase	0.0212	0.1642	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0212	0.1642	0.1491
Brugia malayi	Guanylyl cyclase protein 23	0.0212	0.1642	0.3249
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0212	0.1642	0.1491
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0212	0.1642	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Brugia malayi	RhoGAP domain containing protein	0.0315	0.2757	0.5455
Brugia malayi	Variant SH3 domain containing protein	0.0315	0.2757	0.5455
Echinococcus granulosus	protein tyrosine kinase	0.0212	0.1642	0.3004
Echinococcus granulosus	SHC transforming protein 3	0.0315	0.2757	0.5289
Loa Loa (eye worm)	SH2 domain-containing protein	0.0315	0.2757	0.5455
Loa Loa (eye worm)	TK/FER protein kinase	0.0528	0.5054	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0315	0.2757	0.2626
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0212	0.1642	0.3249
Echinococcus multilocularis	transfer RNA-Thr	0.0212	0.1642	0.1491
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Loa Loa (eye worm)	STAT protein	0.0315	0.2757	0.5455
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Brugia malayi	SH2 domain containing protein	0.0315	0.2757	0.5455
Brugia malayi	Receptor family ligand binding region containing protein	0.0212	0.1642	0.3249
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0315	0.2757	0.3267
Brugia malayi	SH2 domain containing protein	0.0528	0.5054	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0315	0.2757	0.5289
Trichomonas vaginalis	conserved hypothetical protein	0.0212	0.1642	0.5
Echinococcus granulosus	c src tyrosine kinase	0.0528	0.5054	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0212	0.1642	0.1491
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0212	0.1642	0.3004
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0212	0.1642	0.3004
Brugia malayi	Protein kinase domain containing protein	0.0528	0.5054	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0315	0.2757	0.5289
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Schistosoma mansoni	protein kinase	0.0212	0.1642	0.3004
Loa Loa (eye worm)	TK protein kinase	0.0212	0.1642	0.3249
Loa Loa (eye worm)	TK/FER protein kinase	0.0528	0.5054	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0528	0.5054	1
Loa Loa (eye worm)	SRC-1	0.0528	0.5054	1
Echinococcus granulosus	tyrosine kinase	0.0528	0.5054	1
Loa Loa (eye worm)	hypothetical protein	0.0315	0.2757	0.5455
Brugia malayi	SH2 domain containing protein	0.0315	0.2757	0.5455
Echinococcus multilocularis	insulin receptor	0.0212	0.1642	0.1491
Onchocerca volvulus		0.0528	0.5054	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0528	0.5054	0.4965
Trichomonas vaginalis	conserved hypothetical protein	0.0212	0.1642	0.5
Loa Loa (eye worm)	serine/threonine protein kinase	0.0212	0.1642	0.3249
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0212	0.1642	0.3249
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0212	0.1642	0.3004
Echinococcus granulosus	tyrosine protein kinase shark	0.0528	0.5054	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0212	0.1642	0.3249
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0212	0.1642	0.5
Loa Loa (eye worm)	TK/ALK protein kinase	0.0212	0.1642	0.3249
Loa Loa (eye worm)	TK protein kinase	0.0212	0.1642	0.3249
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Echinococcus multilocularis	epidermal growth factor receptor	0.0212	0.1642	0.1491
Echinococcus granulosus	ephrin type A receptor 4 A	0.0212	0.1642	0.3004
Echinococcus multilocularis	SH2 motif	0.0315	0.2757	0.2626
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249
Loa Loa (eye worm)	TK protein kinase	0.0212	0.1642	0.3249
Brugia malayi	SH2 domain containing protein	0.0315	0.2757	0.5455
Onchocerca volvulus		0.0315	0.2757	0.3267
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0315	0.2757	0.2626
Loa Loa (eye worm)	TK/FER protein kinase	0.0212	0.1642	0.3249
Brugia malayi	Protein kinase domain containing protein	0.0528	0.5054	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0212	0.1642	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Loa Loa (eye worm)	TK protein kinase	0.0212	0.1642	0.3249
Loa Loa (eye worm)	hypothetical protein	0.0315	0.2757	0.5455
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0212	0.1642	0.1491
Echinococcus granulosus	SH2 motif	0.0315	0.2757	0.5289
Loa Loa (eye worm)	TK/FER protein kinase	0.0528	0.5054	1
Echinococcus granulosus	epidermal growth factor receptor	0.0212	0.1642	0.3004
Loa Loa (eye worm)	hypothetical protein	0.0315	0.2757	0.5455
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Leishmania major	protein kinase, putative	0.0212	0.1642	0.5
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0212	0.1642	0.3249
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0212	0.1642	0.1491
Schistosoma mansoni	protein kinase	0.0212	0.1642	0.3004
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Entamoeba histolytica	protein kinase, putative	0.0315	0.2757	0.3267
Brugia malayi	SH2 domain containing protein	0.0315	0.2757	0.5455
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0315	0.2757	0.2626
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0315	0.2757	0.5289
Loa Loa (eye worm)	TK/FAK protein kinase	0.0212	0.1642	0.3249
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0212	0.1642	0.1491
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0212	0.1642	0.1491
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0212	0.1642	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0315	0.2757	0.2626
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0212	0.1642	0.5
Onchocerca volvulus		0.0315	0.2757	0.3267
Brugia malayi	Tyrosine-protein kinase abl-1	0.0528	0.5054	1
Echinococcus granulosus	integrin linked protein kinase	0.0212	0.1642	0.3004
Schistosoma mansoni	tyrosine kinase	0.0212	0.1642	0.3004
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0212	0.1642	0.3249
Brugia malayi	Protein kinase domain containing protein	0.0528	0.5054	1
Echinococcus multilocularis	integrin linked protein kinase	0.0212	0.1642	0.1491
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0212	0.1642	0.3249
Trichomonas vaginalis	conserved hypothetical protein	0.0212	0.1642	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0528	0.5054	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0212	0.1642	0.1491
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0315	0.2757	0.5289
Brugia malayi	Sex muscle abnormal protein 5	0.0315	0.2757	0.5455
Loa Loa (eye worm)	TK/CSK protein kinase	0.0212	0.1642	0.3249
Echinococcus multilocularis	SHC transforming protein 3	0.0315	0.2757	0.2626
Loa Loa (eye worm)	hypothetical protein	0.0212	0.1642	0.3249
Echinococcus granulosus	tyrosine protein kinase Srms	0.0528	0.5054	1
Loa Loa (eye worm)	hypothetical protein	0.0315	0.2757	0.5455
Brugia malayi	Protein kinase domain containing protein	0.0212	0.1642	0.3249

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	33.1734 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2358616

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1751532