Detailed information for compound 1752001

Basic information

Technical information
  • TDR Targets ID: 1752001
  • Name: N-[(4-ethoxy-3-methoxyphenyl)methyl]-2,3-diet hylquinoxaline-6-carboxamide
  • MW: 393.479 | Formula: C23H27N3O3
  • H donors: 1 H acceptors: 3 LogP: 3.95 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1OC)CNC(=O)c1ccc2c(c1)nc(c(n2)CC)CC
  • InChi: 1S/C23H27N3O3/c1-5-17-18(6-2)26-20-13-16(9-10-19(20)25-17)23(27)24-14-15-8-11-21(29-7-3)22(12-15)28-4/h8-13H,5-7,14H2,1-4H3,(H,24,27)
  • InChiKey: RPRCMFIOLINXBK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(4-ethoxy-3-methoxy-phenyl)methyl]-2,3-diethyl-quinoxaline-6-carboxamide
  • N-[(4-ethoxy-3-methoxyphenyl)methyl]-2,3-diethyl-6-quinoxalinecarboxamide
  • N-(4-ethoxy-3-methoxy-benzyl)-2,3-diethyl-quinoxaline-6-carboxamide
  • K216-8309
  • NCGC00138082-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Regulator of G protein signaling 20 0.017 0.0966 0.0587
Schistosoma mansoni axis inhibition protein axin 0.017 0.0966 0.0494
Toxoplasma gondii AGC kinase 0.006 0 0.5
Echinococcus multilocularis axis inhibition protein axin 0.017 0.0966 0.0587
Entamoeba histolytica hypothetical protein 0.017 0.0966 1
Echinococcus granulosus regulator of G protein signaling 3 0.017 0.0966 0.0587
Loa Loa (eye worm) RGS-3 protein 0.017 0.0966 0.0966
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0966 1
Schistosoma mansoni z-protein (S1r protein) 0.017 0.0966 0.0494
Loa Loa (eye worm) PXA domain-containing protein 0.017 0.0966 0.0966
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.017 0.0966 0.0587
Echinococcus multilocularis regulator of G protein signaling 7 0.017 0.0966 0.0587
Brugia malayi Regulator of G protein signaling domain containing protein 0.017 0.0966 0.0966
Brugia malayi regulator of G-protein signaling rgs-7 0.017 0.0966 0.0966
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0089 0.0251 0.0251
Echinococcus granulosus axis inhibition protein axin 0.017 0.0966 0.0587
Echinococcus granulosus Regulator of G protein signaling 20 0.017 0.0966 0.0587
Echinococcus multilocularis expressed protein 0.017 0.0966 0.0587
Echinococcus multilocularis regulator of G protein signaling 7 0.017 0.0966 0.0587
Echinococcus multilocularis G protein coupled receptor kinase 6 0.1027 0.8503 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.017 0.0966 0.0966
Echinococcus granulosus beta-adrenergic receptor kinase 0.0175 0.101 0.0642
Echinococcus granulosus regulator of G protein signaling 7 0.017 0.0966 0.0587
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.1027 0.8503 0.8503
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1027 0.8503 0.8503
Echinococcus multilocularis regulator of G protein signaling 0.017 0.0966 0.0587
Schistosoma mansoni regulator of G protein signaling 0.017 0.0966 0.0494
Echinococcus granulosus regulator of G protein signaling 7 0.017 0.0966 0.0587
Echinococcus multilocularis rho associated protein kinase 0.0151 0.0794 0.0372
Schistosoma mansoni axis inhibition protein axin 0.017 0.0966 0.0494
Brugia malayi A-kinase anchor protein 10, precursor 0.017 0.0966 0.0966
Echinococcus granulosus expressed protein 0.017 0.0966 0.0587
Loa Loa (eye worm) hypothetical protein 0.017 0.0966 0.0966
Brugia malayi Protein kinase domain containing protein 0.0458 0.3497 0.3497
Schistosoma mansoni regulator of G protein signaling 0.017 0.0966 0.0494
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.0794 0.0313
Brugia malayi PXA domain containing protein 0.017 0.0966 0.0966
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0089 0.0251 0.5
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0966 1
Brugia malayi hypothetical protein 0.017 0.0966 0.0966
Brugia malayi hypothetical protein 0.017 0.0966 0.0966
Echinococcus multilocularis beta adrenergic receptor kinase 0.0175 0.101 0.0642
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0966 1
Schistosoma mansoni regulator of G protein signaling 0.017 0.0966 0.0494
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.017 0.0966 0.0587
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0458 0.3497 0.3497
Schistosoma mansoni serine/threonine protein kinase 0.1198 1 1
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.017 0.0966 1
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0966 1
Loa Loa (eye worm) hypothetical protein 0.017 0.0966 0.0966
Giardia lamblia Kinase, AGC AKT 0.0089 0.0251 0.5
Schistosoma mansoni regulator of G protein signaling 0.017 0.0966 0.0494
Echinococcus granulosus rho-associated protein kinase 1 0.0151 0.0794 0.0372
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.101 0.0541
Entamoeba histolytica hypothetical protein 0.017 0.0966 1
Entamoeba histolytica hypothetical protein 0.017 0.0966 1
Echinococcus multilocularis axis inhibition protein axin 0.017 0.0966 0.0587
Echinococcus granulosus axis inhibition protein axin 0.017 0.0966 0.0587
Onchocerca volvulus 0.0151 0.0794 1
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.101 0.0541
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1198 1 1
Loa Loa (eye worm) hypothetical protein 0.017 0.0966 0.0966
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0117 0.0496 0.0496
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.017 0.0966 0.0494
Loa Loa (eye worm) hypothetical protein 0.017 0.0966 0.0966
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.017 0.0966 0.0494
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0966 1
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0966 1
Echinococcus multilocularis regulator of G protein signaling 3 0.017 0.0966 0.0587
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.1027 0.8503 1
Schistosoma mansoni regulator of G protein signaling 0.017 0.0966 0.0494
Echinococcus multilocularis regulator of G protein signaling 3 0.017 0.0966 0.0587
Loa Loa (eye worm) hypothetical protein 0.017 0.0966 0.0966
Trypanosoma brucei rac serine-threonine kinase, putative 0.006 0 0.5
Loa Loa (eye worm) hypothetical protein 0.017 0.0966 0.0966
Brugia malayi regulator of G-protein signaling egl-10 0.017 0.0966 0.0966
Echinococcus granulosus regulator of G protein signaling 3 0.017 0.0966 0.0587
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.017 0.0966 0.0494
Brugia malayi Regulator of G protein signaling domain containing protein 0.017 0.0966 0.0966
Brugia malayi PXA domain containing protein 0.017 0.0966 0.0966
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0175 0.101 0.101
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1027 0.8503 0.8503

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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