Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adrenergic receptor alpha-2 | Starlite/ChEMBL | References |
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | alpha 1A adrenergic receptor | Adrenergic receptor alpha-2 | 450 aa | 478 aa | 20.7 % |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Adrenergic receptor alpha-2 | 450 aa | 378 aa | 20.9 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Adrenergic receptor alpha-2 | 450 aa | 423 aa | 31.7 % |
Echinococcus multilocularis | fmrfamide receptor | Adrenergic receptor alpha-2 | 450 aa | 366 aa | 19.9 % |
Echinococcus granulosus | alpha 1A adrenergic receptor | Adrenergic receptor alpha-2 | 450 aa | 476 aa | 21.0 % |
Schistosoma mansoni | amine GPCR | Adrenergic receptor alpha-2 | 450 aa | 439 aa | 29.2 % |
Onchocerca volvulus | Adrenergic receptor alpha-2 | 450 aa | 467 aa | 25.1 % | |
Echinococcus multilocularis | serotonin receptor | Adrenergic receptor alpha-2 | 450 aa | 426 aa | 31.9 % |
Onchocerca volvulus | Adrenergic receptor alpha-2 | 450 aa | 420 aa | 19.8 % | |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Adrenergic receptor alpha-2 | 450 aa | 473 aa | 24.1 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Adrenergic receptor alpha-2 | 450 aa | 433 aa | 27.9 % |
Loa Loa (eye worm) | TYRA-2 protein | Adrenergic receptor alpha-2 | 450 aa | 488 aa | 23.8 % |
Echinococcus multilocularis | neuropeptides capa receptor | Adrenergic receptor alpha-2 | 450 aa | 486 aa | 20.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.5224 | 0.0037 | 0.0037 |
Schistosoma mansoni | serine/threonine protein kinase | 0.5224 | 0.0037 | 0.0037 |
Echinococcus multilocularis | maternal embryonic leucine zipper kinase | 1.0487 | 0.5056 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/MELK protein kinase | 1.5671 | 1 | 1 |
Echinococcus multilocularis | calcium activated potassium channel | 0.5224 | 0.0037 | 0.0074 |
Echinococcus granulosus | maternal embryonic leucine zipper kinase | 1.0487 | 0.5056 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.5224 | 0.0037 | 0.0074 |
Trichomonas vaginalis | CAMK family protein kinase | 1.5671 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.5224 | 0.0037 | 0.0037 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.5224 | 0.0037 | 0.0074 |
Schistosoma mansoni | serine/threonine protein kinase | 0.5224 | 0.0037 | 0.0037 |
Schistosoma mansoni | serine/threonine protein kinase | 0.5224 | 0.0037 | 0.0037 |
Schistosoma mansoni | serine/threonine kinase | 1.5671 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 9.29 nM | Binding affinity towards Alpha-1 adrenergic receptor measured by displacement of [3H]-prazosin from rat brain cortex membranes | ChEMBL. | 9703460 |
Ki (binding) | = 9.29 nM | Binding affinity towards Alpha-1 adrenergic receptor measured by displacement of [3H]-prazosin from rat brain cortex membranes | ChEMBL. | 9703460 |
Ki (binding) | = 4510 nM | Displacement of clonidine from Alpha-2 adrenergic receptor in rat brain cortex | ChEMBL. | 9703460 |
Ki (binding) | = 4510 nM | Displacement of clonidine from Alpha-2 adrenergic receptor in rat brain cortex | ChEMBL. | 9703460 |
Ratio (binding) | = 486 | Selectivity ratio for binding affinity towards alpha2 and alpha1 adrenoceptors | ChEMBL. | 9703460 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.