Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sentrin specific protease 8 | 0.0069 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.6754 | 0.6754 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.6754 | 0.6754 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0053 | 0.6754 | 0.6754 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0053 | 0.6754 | 0.6754 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0069 | 1 | 1 |
Entamoeba histolytica | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0069 | 1 | 1 |
Trichomonas vaginalis | Sentrin-specific protease, putative | 0.0069 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein | 0.0069 | 1 | 1 |
Echinococcus granulosus | sentrin specific protease 8 | 0.0069 | 1 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0053 | 0.6754 | 0.6754 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0053 | 0.6754 | 1 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0069 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0053 | 0.6754 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0053 | 0.6754 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0053 | 0.6754 | 0.6754 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0069 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0053 | 0.6754 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0053 | 0.6754 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0053 | 0.6754 | 0.6754 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0053 | 0.6754 | 0.6754 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0069 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0053 | 0.6754 | 0.6754 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0053 | 0.6754 | 0.6754 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0053 | 0.6754 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.6754 | 0.6754 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0053 | 0.6754 | 0.6754 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | Ulp1 protease | 0.0069 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0053 | 0.6754 | 0.6754 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0053 | 0.6754 | 0.6754 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.6754 | 0.6754 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.