Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1333 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.096 | 0.096 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0189 | 0.1002 | 0.0579 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0118 | 0.0448 | 0.0448 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0183 | 0.096 | 0.0535 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.096 | 0.096 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0183 | 0.096 | 1 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.1149 | 0.8559 | 1 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0183 | 0.096 | 0.0631 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0183 | 0.096 | 1 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0183 | 0.096 | 0.0535 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0061 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.096 | 0.096 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0183 | 0.096 | 0.0631 |
Schistosoma mansoni | regulator of G protein signaling | 0.0183 | 0.096 | 0.0535 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0183 | 0.096 | 0.096 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0183 | 0.096 | 0.0631 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0183 | 0.096 | 0.0535 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.096 | 0.096 |
Brugia malayi | PXA domain containing protein | 0.0183 | 0.096 | 0.096 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0183 | 0.096 | 0.096 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0189 | 0.1002 | 0.1002 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.1149 | 0.8559 | 0.8559 |
Echinococcus granulosus | expressed protein | 0.0183 | 0.096 | 0.0631 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0183 | 0.096 | 0.096 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.096 | 0.096 |
Schistosoma mansoni | regulator of G protein signaling | 0.0183 | 0.096 | 0.0535 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0152 | 0.0717 | 0.0281 |
Brugia malayi | Protein kinase domain containing protein | 0.0463 | 0.3159 | 0.3159 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0183 | 0.096 | 1 |
Brugia malayi | hypothetical protein | 0.0183 | 0.096 | 0.096 |
Brugia malayi | PXA domain containing protein | 0.0183 | 0.096 | 0.096 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.009 | 0.0226 | 0.5 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0189 | 0.1002 | 0.0682 |
Brugia malayi | hypothetical protein | 0.0183 | 0.096 | 0.096 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0183 | 0.096 | 0.0631 |
Schistosoma mansoni | regulator of G protein signaling | 0.0183 | 0.096 | 0.0535 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0183 | 0.096 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1333 | 1 | 1 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.0463 | 0.3159 | 0.3159 |
Schistosoma mansoni | regulator of G protein signaling | 0.0183 | 0.096 | 0.0535 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0189 | 0.1002 | 0.0579 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.0152 | 0.0717 | 0.0331 |
Entamoeba histolytica | hypothetical protein | 0.0183 | 0.096 | 1 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0183 | 0.096 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0183 | 0.096 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.096 | 0.096 |
Giardia lamblia | Kinase, AGC AKT | 0.009 | 0.0226 | 0.5 |
Echinococcus granulosus | axis inhibition protein axin | 0.0183 | 0.096 | 0.0631 |
Onchocerca volvulus | 0.0152 | 0.0717 | 1 | |
Echinococcus multilocularis | axis inhibition protein axin | 0.0183 | 0.096 | 0.0631 |
Entamoeba histolytica | hypothetical protein | 0.0183 | 0.096 | 1 |
Brugia malayi | ribosomal protein S6 kinase alpha 3 | 0.009 | 0.0226 | 0.0226 |
Echinococcus granulosus | axis inhibition protein axin | 0.0183 | 0.096 | 0.0631 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0183 | 0.096 | 0.096 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0183 | 0.096 | 0.0631 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0183 | 0.096 | 0.0631 |
Echinococcus multilocularis | expressed protein | 0.0183 | 0.096 | 0.0631 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0183 | 0.096 | 0.0631 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0183 | 0.096 | 0.096 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0189 | 0.1002 | 0.0682 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.1149 | 0.8559 | 1 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.1149 | 0.8559 | 0.8559 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0183 | 0.096 | 0.0631 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1149 | 0.8559 | 0.8559 |
Schistosoma mansoni | axis inhibition protein axin | 0.0183 | 0.096 | 0.0535 |
Echinococcus multilocularis | rho associated protein kinase | 0.0152 | 0.0717 | 0.0331 |
Schistosoma mansoni | regulator of G protein signaling | 0.0183 | 0.096 | 0.0535 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0183 | 0.096 | 0.0631 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0183 | 0.096 | 0.0631 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0183 | 0.096 | 0.0631 |
Toxoplasma gondii | AGC kinase | 0.0061 | 0 | 0.5 |
Schistosoma mansoni | axis inhibition protein axin | 0.0183 | 0.096 | 0.0535 |
Entamoeba histolytica | hypothetical protein | 0.0183 | 0.096 | 1 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0183 | 0.096 | 0.0631 |
Loa Loa (eye worm) | RGS-3 protein | 0.0183 | 0.096 | 0.096 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0183 | 0.096 | 0.0535 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0183 | 0.096 | 1 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0183 | 0.096 | 0.096 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0183 | 0.096 | 0.0631 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0183 | 0.096 | 0.0631 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0183 | 0.096 | 0.096 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 23.1093 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.