Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0123 | 0.1588 | 0.1588 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0123 | 0.1588 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0728 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0123 | 0.1588 | 0.1588 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0123 | 0.1588 | 0.1588 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0123 | 0.1588 | 0.1588 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0728 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0728 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0123 | 0.1588 | 0.1588 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0123 | 0.1588 | 0.1588 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1588 | 0.1588 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0123 | 0.1588 | 0.1588 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.03 | 0.4057 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0123 | 0.1588 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0129 | 0.1669 | 0.1669 |
Onchocerca volvulus | 0.0123 | 0.1588 | 0.5 | |
Schistosoma mansoni | gliotactin | 0.0123 | 0.1588 | 0.1588 |
Onchocerca volvulus | 0.0123 | 0.1588 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0728 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0123 | 0.1588 | 0.1588 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0728 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0129 | 0.1669 | 0.1669 |
Loa Loa (eye worm) | carboxylesterase | 0.0728 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0123 | 0.1588 | 0.1588 |
Loa Loa (eye worm) | hypothetical protein | 0.0728 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1588 | 0.1588 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0123 | 0.1588 | 0.1588 |
Echinococcus multilocularis | neuroligin | 0.0123 | 0.1588 | 0.1588 |
Brugia malayi | Carboxylesterase family protein | 0.0728 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0129 | 0.1669 | 0.1669 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1588 | 0.1588 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.03 | 0.4057 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0728 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0728 | 1 | 1 |
Onchocerca volvulus | 0.0123 | 0.1588 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1588 | 0.1588 |
Echinococcus granulosus | carboxylesterase 5A | 0.0728 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0123 | 0.1588 | 0.1588 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0123 | 0.1588 | 0.1588 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1588 | 0.1588 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1588 | 0.1588 |
Brugia malayi | Carboxylesterase family protein | 0.0123 | 0.1588 | 0.1588 |
Onchocerca volvulus | 0.0123 | 0.1588 | 0.5 | |
Schistosoma mansoni | acetylcholinesterase | 0.0123 | 0.1588 | 0.1588 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1588 | 0.1588 |
Echinococcus granulosus | acetylcholinesterase | 0.0728 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0123 | 0.1588 | 0.1588 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0123 | 0.1588 | 0.1588 |
Brugia malayi | hypothetical protein | 0.0123 | 0.1588 | 0.1588 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0123 | 0.1588 | 0.1588 |
Onchocerca volvulus | 0.0123 | 0.1588 | 0.5 | |
Echinococcus granulosus | neuroligin | 0.0123 | 0.1588 | 0.1588 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0123 | 0.1588 | 0.1588 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.