Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.015 | 0.0797 | 1 | |
Schistosoma mansoni | regulator of G protein signaling | 0.0157 | 0.0866 | 0.0388 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0088 | 0.0251 | 0.5 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0157 | 0.0866 | 0.0866 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0157 | 0.0866 | 1 |
Schistosoma mansoni | regulator of G protein signaling | 0.0157 | 0.0866 | 0.0388 |
Echinococcus granulosus | expressed protein | 0.0157 | 0.0866 | 0.0454 |
Schistosoma mansoni | regulator of G protein signaling | 0.0157 | 0.0866 | 0.0388 |
Entamoeba histolytica | hypothetical protein | 0.0157 | 0.0866 | 1 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0157 | 0.0866 | 0.0388 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0866 | 0.0866 |
Brugia malayi | hypothetical protein | 0.0157 | 0.0866 | 0.0866 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0866 | 0.0866 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0116 | 0.0498 | 0.0498 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0157 | 0.0866 | 0.0866 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.103 | 0.8604 | 0.8604 |
Brugia malayi | PXA domain containing protein | 0.0157 | 0.0866 | 0.0866 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0866 | 0.0866 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.006 | 0 | 0.5 |
Echinococcus multilocularis | rho associated protein kinase | 0.015 | 0.0797 | 0.0368 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1188 | 1 | 1 |
Schistosoma mansoni | axis inhibition protein axin | 0.0157 | 0.0866 | 0.0388 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1188 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0157 | 0.0866 | 1 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.103 | 0.8604 | 0.8604 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0157 | 0.0866 | 0.0454 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0157 | 0.0866 | 1 |
Echinococcus multilocularis | expressed protein | 0.0157 | 0.0866 | 0.0454 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0157 | 0.0866 | 0.0454 |
Schistosoma mansoni | regulator of G protein signaling | 0.0157 | 0.0866 | 0.0388 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0157 | 0.0866 | 0.0388 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0157 | 0.0866 | 0.0454 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0157 | 0.0866 | 0.0454 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0157 | 0.0866 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0162 | 0.0908 | 0.0431 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.103 | 0.8604 | 1 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.0455 | 0.3509 | 0.3509 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.103 | 0.8604 | 1 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.103 | 0.8604 | 0.8604 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0157 | 0.0866 | 0.0454 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0157 | 0.0866 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0866 | 0.0866 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0157 | 0.0866 | 1 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0162 | 0.0908 | 0.0908 |
Brugia malayi | PXA domain containing protein | 0.0157 | 0.0866 | 0.0866 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0157 | 0.0866 | 0.0866 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0157 | 0.0866 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0157 | 0.0866 | 1 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0157 | 0.0866 | 0.0866 |
Schistosoma mansoni | axis inhibition protein axin | 0.0157 | 0.0866 | 0.0388 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0157 | 0.0866 | 0.0388 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0866 | 0.0866 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0157 | 0.0866 | 0.0454 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0157 | 0.0866 | 0.0454 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0157 | 0.0866 | 0.0454 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0162 | 0.0908 | 0.0506 |
Brugia malayi | hypothetical protein | 0.0157 | 0.0866 | 0.0866 |
Loa Loa (eye worm) | RGS-3 protein | 0.0157 | 0.0866 | 0.0866 |
Schistosoma mansoni | regulator of G protein signaling | 0.0157 | 0.0866 | 0.0388 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0157 | 0.0866 | 0.0454 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0157 | 0.0866 | 0.0454 |
Brugia malayi | Protein kinase domain containing protein | 0.0455 | 0.3509 | 0.3509 |
Giardia lamblia | Kinase, AGC AKT | 0.0088 | 0.0251 | 0.5 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0162 | 0.0908 | 0.0506 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0157 | 0.0866 | 0.0454 |
Toxoplasma gondii | AGC kinase | 0.006 | 0 | 0.5 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0157 | 0.0866 | 0.0454 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0157 | 0.0866 | 0.0866 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0157 | 0.0866 | 0.0454 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0157 | 0.0866 | 0.0454 |
Entamoeba histolytica | hypothetical protein | 0.0157 | 0.0866 | 1 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0157 | 0.0866 | 0.0866 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0866 | 0.0866 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0162 | 0.0908 | 0.0431 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0157 | 0.0866 | 0.0866 |
Schistosoma mansoni | serine/threonine protein kinase | 0.015 | 0.0797 | 0.0314 |
Brugia malayi | ribosomal protein S6 kinase alpha 3 | 0.0088 | 0.0251 | 0.0251 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.015 | 0.0797 | 0.0368 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0157 | 0.0866 | 0.0454 |
Echinococcus granulosus | axis inhibition protein axin | 0.0157 | 0.0866 | 0.0454 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0157 | 0.0866 | 0.0388 |
Echinococcus granulosus | axis inhibition protein axin | 0.0157 | 0.0866 | 0.0454 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.