TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 316.441 | Formula: C16H16N2OS2
H donors: 1 H acceptors: 2 LogP: 3.94 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CS/C(=C/c2sc(c(n2)c2ccccc2)C(C)C)/N1
InChi: 1S/C16H16N2OS2/c1-10(2)16-15(11-6-4-3-5-7-11)18-14(21-16)8-13-17-12(19)9-20-13/h3-8,10H,9H2,1-2H3,(H,17,19)/b13-8+
InChiKey: GCEOSQNOFSFJIN-MDWZMJQESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ADAM metallopeptidase with thrombospondin type 1 motif, 5	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	a disintegrin and metalloproteinase with	Get druggable targets OG5_126771	All targets in OG5_126771
Schistosoma japonicum	ko:K08624 ADAM metallopeptidase with thrombospondin type 1 motif, 9, putative	Get druggable targets OG5_126771	All targets in OG5_126771
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126771	All targets in OG5_126771
Brugia malayi	ADAM-TS Spacer 1 family protein	Get druggable targets OG5_126771	All targets in OG5_126771
Schistosoma mansoni	ADAMTS5 peptidase (M12 family)	Get druggable targets OG5_126771	All targets in OG5_126771
Echinococcus granulosus	a disintegrin and metalloproteinase with	Get druggable targets OG5_126771	All targets in OG5_126771

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TYRA-2 protein	0.007	0.0192	0.4694
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.007	0.0192	0.0132
Onchocerca volvulus		0.0058	0.0131	0.6823
Schistosoma mansoni	neuropeptide receptor	0.007	0.0192	0.0132
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.0192	0.0132
Loa Loa (eye worm)	neuropeptide F receptor	0.007	0.0192	0.4694
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0408	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.007	0.0192	0.0132
Echinococcus granulosus	tm gpcr rhodopsin	0.007	0.0192	0.0132
Toxoplasma gondii	PAN domain-containing protein	0.0909	0.4771	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.007	0.0192	0.0132
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.007	0.0192	0.2194
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.0192	0.0132
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.007	0.0192	0.4694
Echinococcus multilocularis	serotonin receptor	0.007	0.0192	0.0132
Echinococcus multilocularis	fmrfamide receptor	0.007	0.0192	0.0132
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.007	0.0192	0.0132
Echinococcus granulosus	fmrfamide receptor	0.007	0.0192	0.0132
Brugia malayi	hypothetical protein	0.007	0.0192	0.2194
Schistosoma mansoni	growth hormone secretagogue receptor	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Onchocerca volvulus		0.007	0.0192	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.0192	0.0132
Loa Loa (eye worm)	PAN domain-containing protein	0.0058	0.0131	0.3203
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.007	0.0192	0.4694
Loa Loa (eye worm)	PAN domain-containing protein	0.0058	0.0131	0.3203
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Schistosoma mansoni	biogenic amine (5HT) receptor	0.007	0.0192	0.0132
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.0192	0.0132
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.007	0.0192	0.0132
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.007	0.0192	0.0132
Echinococcus granulosus	g-protein coupled receptor	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.007	0.0192	0.0132
Brugia malayi	hypothetical protein	0.007	0.0192	0.2194
Echinococcus granulosus	7tm_1 domain containing protein	0.007	0.0192	0.0132
Echinococcus multilocularis	fmrfamide receptor	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0131	0.3203
Onchocerca volvulus		0.0058	0.0131	0.6823
Schistosoma mansoni	amine GPCR	0.007	0.0192	0.0132
Echinococcus granulosus	neuropeptide Y receptor	0.007	0.0192	0.0132
Brugia malayi	Serotonin receptor	0.007	0.0192	0.2194
Onchocerca volvulus		0.007	0.0192	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.0192	0.0132
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.007	0.0192	0.0132
Schistosoma mansoni	amine GPCR	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.0192	0.0132
Onchocerca volvulus		0.0058	0.0131	0.6823
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.007	0.0192	0.0132
Brugia malayi	larval opioid receptor	0.007	0.0192	0.2194
Onchocerca volvulus		0.007	0.0192	1
Onchocerca volvulus		0.007	0.0192	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.007	0.0192	0.0132
Schistosoma mansoni	adenoreceptor	0.007	0.0192	0.0132
Schistosoma mansoni	hypothetical protein	0.007	0.0192	0.0132
Onchocerca volvulus		0.007	0.0192	1
Brugia malayi	hypothetical protein	0.007	0.0192	0.2194
Echinococcus multilocularis	serotonin receptor	0.007	0.0192	0.0132
Echinococcus granulosus	neuropeptides capa receptor	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Echinococcus multilocularis	orexin receptor type 2	0.007	0.0192	0.0132
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0131	0.3203
Loa Loa (eye worm)	G-protein coupled receptor	0.007	0.0192	0.4694
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0131	0.3203
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.0192	0.0132
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Loa Loa (eye worm)	melatonin receptor type 1A	0.007	0.0192	0.4694
Echinococcus multilocularis	neuropeptide FF receptor 2	0.007	0.0192	0.0132
Echinococcus multilocularis	neuropeptides capa receptor	0.007	0.0192	0.0132
Echinococcus granulosus	dro:myosuppressin receptor	0.007	0.0192	0.0132
Echinococcus multilocularis	neuropeptides capa receptor	0.007	0.0192	0.0132
Echinococcus multilocularis	g protein coupled receptor	0.007	0.0192	0.0132
Onchocerca volvulus		0.0058	0.0131	0.6823
Echinococcus multilocularis	g protein coupled receptor	0.007	0.0192	0.0132
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.007	0.0192	0.0132
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.007	0.0192	0.2194
Schistosoma mansoni	hypothetical protein	0.007	0.0192	0.0132
Schistosoma mansoni	biogenic amine receptor	0.007	0.0192	0.0132
Loa Loa (eye worm)	PAN domain-containing protein	0.0058	0.0131	0.3203
Brugia malayi	Dopamine receptor protein 1	0.007	0.0192	0.2194
Schistosoma mansoni	histamine h1 receptor	0.007	0.0192	0.0132
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.0192	0.0132
Brugia malayi	RE15519p	0.007	0.0192	0.2194
Brugia malayi	Melatonin receptor type 1A	0.007	0.0192	0.2194
Schistosoma mansoni	biogenic amine receptor	0.007	0.0192	0.0132
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.007	0.0192	0.2194
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.007	0.0192	0.0132
Echinococcus granulosus	g protein coupled receptor	0.007	0.0192	0.0132
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.0192	0.0132
Echinococcus granulosus	neuropeptide receptor A26	0.007	0.0192	0.0132
Schistosoma mansoni	neuropeptide F-like receptor	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Echinococcus granulosus	g protein coupled receptor	0.007	0.0192	0.0132
Schistosoma mansoni	myosin xvIII	0.007	0.0192	0.0132
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.0192	0.0132
Brugia malayi	hypothetical protein	0.007	0.0192	0.2194
Echinococcus multilocularis	sex peptide receptor	0.007	0.0192	0.0132
Toxoplasma gondii	PAN domain-containing protein	0.0909	0.4771	1
Schistosoma mansoni	opsin-like receptor	0.007	0.0192	0.0132
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.0192	0.0132
Onchocerca volvulus		0.0058	0.0131	0.6823
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.007	0.0192	0.2194
Onchocerca volvulus		0.007	0.0192	1
Brugia malayi	hypothetical protein	0.007	0.0192	0.2194
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.0192	0.0132
Schistosoma mansoni	hypothetical protein	0.007	0.0192	0.0132
Schistosoma mansoni	neuropeptide receptor	0.007	0.0192	0.0132
Brugia malayi	G protein-coupled receptor F59B2.13	0.007	0.0192	0.2194
Brugia malayi	follicle stimulating hormone receptor	0.007	0.0192	0.2194
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Brugia malayi	hypothetical protein	0.007	0.0192	0.2194
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Echinococcus multilocularis	g-protein coupled receptor	0.007	0.0192	0.0132
Echinococcus multilocularis	allatostatin A receptor	0.007	0.0192	0.0132
Onchocerca volvulus		0.0058	0.0131	0.6823
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.0192	0.0132
Echinococcus multilocularis	somatostatin receptor	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.007	0.0192	0.0132
Onchocerca volvulus		0.0058	0.0131	0.6823
Schistosoma mansoni	opsin-like receptor	0.007	0.0192	0.0132
Brugia malayi	Serotonin receptor	0.007	0.0192	0.2194
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.0192	0.0132
Echinococcus granulosus	orexin receptor type 2	0.007	0.0192	0.0132
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.007	0.0192	0.0132
Echinococcus granulosus	neuropeptide receptor	0.007	0.0192	0.0132
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.0192	0.0132
Schistosoma mansoni	neuropeptide F-like receptor	0.007	0.0192	0.0132
Echinococcus granulosus	neuropeptide FF receptor 2	0.007	0.0192	0.0132
Schistosoma mansoni	neuropeptide receptor	0.1867	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.007	0.0192	0.0132
Brugia malayi	Tachykinin-like peptides receptor 99D	0.007	0.0192	0.2194
Echinococcus multilocularis	G-protein coupled receptor, putative	0.007	0.0192	0.0132
Brugia malayi	AKH receptor	0.007	0.0192	0.2194
Echinococcus granulosus	neuropeptide Y receptor	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Echinococcus granulosus	g protein coupled receptor	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.007	0.0192	0.4694
Echinococcus granulosus	neuropeptides capa receptor	0.007	0.0192	0.0132
Onchocerca volvulus		0.007	0.0192	1
Onchocerca volvulus		0.0058	0.0131	0.6823
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0131	0.3203
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.007	0.0192	0.0132
Loa Loa (eye worm)	G-protein coupled receptor	0.007	0.0192	0.4694
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.0192	0.0132
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0131	0.3203
Brugia malayi	neuropeptide F receptor	0.007	0.0192	0.2194
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.007	0.0192	0.0132
Brugia malayi	Dopamine receptor protein 2	0.007	0.0192	0.2194
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Schistosoma mansoni	opsin-like receptor	0.007	0.0192	0.0132
Onchocerca volvulus	Neuropeptide F receptor homolog	0.007	0.0192	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.0192	0.0132
Echinococcus multilocularis	neuropeptide receptor	0.007	0.0192	0.0132
Schistosoma mansoni	amine GPCR	0.007	0.0192	0.0132
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.007	0.0192	0.0132
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.007	0.0192	0.0132
Onchocerca volvulus		0.007	0.0192	1
Schistosoma mansoni	biogenic amine receptor	0.007	0.0192	0.0132
Brugia malayi	putative neuropeptide receptor	0.007	0.0192	0.2194
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Echinococcus granulosus	sex peptide receptor	0.007	0.0192	0.0132
Brugia malayi	G protein-coupled receptor	0.007	0.0192	0.2194
Echinococcus granulosus	7TM GPCR rhodopsin	0.007	0.0192	0.0132
Brugia malayi	putative neuropeptide receptor NPR1	0.007	0.0192	0.2194
Schistosoma mansoni	neuropeptide receptor	0.007	0.0192	0.0132
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.007	0.0192	0.2194
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.007	0.0192	0.0132
Brugia malayi	G-protein coupled receptor	0.007	0.0192	0.2194
Schistosoma mansoni	biogenic amine (5HT) receptor	0.007	0.0192	0.0132
Brugia malayi	G-protein coupled receptor	0.007	0.0192	0.2194
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.007	0.0192	0.0132
Brugia malayi	hypothetical protein	0.007	0.0192	0.2194
Schistosoma mansoni	amine GPCR	0.007	0.0192	0.0132
Echinococcus granulosus	neuropeptide s receptor	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Brugia malayi	sulfakinin receptor protein	0.007	0.0192	0.2194
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.007	0.0192	0.0132
Brugia malayi	hypothetical protein	0.007	0.0192	0.2194
Onchocerca volvulus		0.007	0.0192	1
Brugia malayi	hypothetical protein	0.007	0.0192	0.2194
Onchocerca volvulus		0.007	0.0192	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Onchocerca volvulus		0.007	0.0192	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.007	0.0192	0.0132
Brugia malayi	hypothetical protein	0.007	0.0192	0.2194
Onchocerca volvulus		0.007	0.0192	1
Echinococcus granulosus	tm gpcr rhodopsin	0.007	0.0192	0.0132
Brugia malayi	ADAM-TS Spacer 1 family protein	0.0109	0.0408	1
Brugia malayi	neuropeptide F receptor	0.007	0.0192	0.2194
Brugia malayi	ORL1-like opioid receptor	0.007	0.0192	0.2194
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.0192	0.0132
Loa Loa (eye worm)	neuropeptide F receptor	0.007	0.0192	0.4694
Echinococcus granulosus	peptide allatostatin:somatostatin	0.007	0.0192	0.0132
Onchocerca volvulus		0.007	0.0192	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0058	0.0131	0.3203
Schistosoma mansoni	hypothetical protein	0.007	0.0192	0.0132
Echinococcus granulosus	alpha 1A adrenergic receptor	0.007	0.0192	0.0132
Echinococcus multilocularis	neuropeptide receptor	0.1867	1	1
Echinococcus multilocularis	neuropeptide receptor A26	0.007	0.0192	0.0132
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.0192	0.0132
Brugia malayi	GnHR receptor homolog	0.007	0.0192	0.2194
Echinococcus multilocularis	neuropeptide Y receptor	0.007	0.0192	0.0132
Schistosoma mansoni	amine GPCR	0.007	0.0192	0.0132
Echinococcus multilocularis	g protein coupled receptor	0.007	0.0192	0.0132
Schistosoma mansoni	neuropeptide f receptor 76f	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Onchocerca volvulus		0.0058	0.0131	0.6823
Brugia malayi	Dopamine receptor	0.007	0.0192	0.2194
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.007	0.0192	0.4694
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.007	0.0192	0.0132
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Echinococcus multilocularis	dro:myosuppressin receptor	0.007	0.0192	0.0132
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.007	0.0192	0.4694
Echinococcus granulosus	hypothetical protein	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.007	0.0192	0.0132
Echinococcus granulosus	biogenic amine 5HT receptor	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0131	0.3203
Echinococcus granulosus	G protein coupled receptor 139	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Onchocerca volvulus		0.0058	0.0131	0.6823
Loa Loa (eye worm)	PAN domain-containing protein	0.0058	0.0131	0.3203
Onchocerca volvulus		0.0058	0.0131	0.6823
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0131	0.3203
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Echinococcus multilocularis	G protein coupled receptor 139	0.1867	1	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.007	0.0192	0.0132
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.007	0.0192	1
Echinococcus granulosus	allatostatin A receptor	0.007	0.0192	0.0132
Onchocerca volvulus		0.007	0.0192	1
Echinococcus granulosus	somatostatin receptor	0.007	0.0192	0.0132
Echinococcus granulosus	serotonin receptor	0.007	0.0192	0.0132
Echinococcus granulosus	tm gpcr rhodopsin	0.007	0.0192	0.0132
Onchocerca volvulus		0.007	0.0192	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Echinococcus multilocularis	neuropeptide s receptor	0.007	0.0192	0.0132
Schistosoma mansoni	alpha-1 adrenergic receptor	0.007	0.0192	0.0132
Onchocerca volvulus		0.007	0.0192	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.007	0.0192	0.0132
Onchocerca volvulus		0.007	0.0192	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.007	0.0192	0.0132
Loa Loa (eye worm)	hypothetical protein	0.007	0.0192	0.4694

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.83 uM	Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method	ChEMBL.	23453070

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2348082

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1753542