TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 354.378 | Formula: C19H19FN4O2
H donors: 1 H acceptors: 2 LogP: 1.71 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Fc1cncc(c1)c1ccc2c(c1)C1(N=C(N(C1=O)C)N)CC(O2)(C)C
InChi: 1S/C19H19FN4O2/c1-18(2)10-19(16(25)24(3)17(21)23-19)14-7-11(4-5-15(14)26-18)12-6-13(20)9-22-8-12/h4-9H,10H2,1-3H3,(H2,21,23)
InChiKey: VXJSSKWZJQSEGW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	beta-site APP-cleaving enzyme 1	Starlite/ChEMBL	References
Homo sapiens	cathepsin D	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium falciparum	plasmepsin IV	Get druggable targets OG5_126885	All targets in OG5_126885
Theileria parva	cathepsin E, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium berghei	plasmepsin IV	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma mansoni	cathepsin D (A01 family)	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium vivax	plasmepsin IV, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Neospora caninum	Pepsinogen A1, related	Get druggable targets OG5_126885	All targets in OG5_126885
Cryptosporidium parvum	membrane bound aspartyl proteinase with a signal peptide plus transmembrane domain	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium yoelii	plasmepsin	Get druggable targets OG5_126885	All targets in OG5_126885
Babesia bovis	eukaryotic aspartyl protease family protein	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_126885	All targets in OG5_126885
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	Get druggable targets OG5_126885	All targets in OG5_126885
Loa Loa (eye worm)	aspartic protease BmAsp-2	Get druggable targets OG5_126885	All targets in OG5_126885
Toxoplasma gondii	aspartyl protease ASP1	Get druggable targets OG5_126885	All targets in OG5_126885
Cryptosporidium hominis	aspartyl protease precursor	Get druggable targets OG5_126885	All targets in OG5_126885
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium falciparum	plasmepsin II	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma japonicum	Cathepsin D precursor, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Theileria parva	pepsinogen, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma japonicum	ko:K01379 cathepsin D [EC3.4.23.5], putative	Get druggable targets OG5_126885	All targets in OG5_126885
Candida albicans	vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C)	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma mansoni	cathepsin D (A01 family)	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium vivax	aspartyl proteinase, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma japonicum	ko:K07747 beta-site APP-cleaving enzyme 2 (memapsin 1) [EC3.4.23.45], putative	Get druggable targets OG5_135830	All targets in OG5_135830
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126885	All targets in OG5_126885
Neospora caninum	Renin, related	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium berghei	plasmepsin VI	Get druggable targets OG5_126885	All targets in OG5_126885
Candida albicans	vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C)	Get druggable targets OG5_126885	All targets in OG5_126885
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium knowlesi	aspartyl protease, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium knowlesi	plasmepsin IV, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma mansoni	memapsin-2 (A01 family)	Get druggable targets OG5_135830	All targets in OG5_135830
Plasmodium falciparum	plasmepsin VI	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium falciparum	plasmepsin I	Get druggable targets OG5_126885	All targets in OG5_126885

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	plasmepsin X	cathepsin D	412 aa	339 aa	28.9 %
Plasmodium falciparum	plasmepsin VII	beta-site APP-cleaving enzyme 1	401 aa	352 aa	21.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Kinase	0.0195	0	0.5
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0287	0.2709	0.3209
Brugia malayi	SH2 domain containing protein	0.0287	0.2709	0.3209
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0287	0.2709	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0287	0.2709	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Echinococcus multilocularis	tensin	0.0287	0.2709	0.3209
Toxoplasma gondii	STE kinase	0.0195	0	0.5
Schistosoma mansoni	tensin	0.0287	0.2709	0.2709
Echinococcus granulosus	hypothetical protein	0.0287	0.2709	0.3209
Echinococcus multilocularis	c src tyrosine kinase	0.0482	0.844	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0195	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0287	0.2709	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0482	0.844	0.844
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0482	0.844	1
Schistosoma mansoni	vav2	0.0287	0.2709	0.2709
Loa Loa (eye worm)	TK/FER protein kinase	0.0482	0.844	1
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0287	0.2709	0.3209
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0482	0.844	1
Brugia malayi	SH2 domain containing protein	0.0287	0.2709	0.3209
Schistosoma mansoni	growth factor receptor-bound protein	0.0287	0.2709	0.2709
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0287	0.2709	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0482	0.844	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0482	0.844	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0287	0.2709	0.3209
Echinococcus multilocularis	SHC transforming protein 3	0.0287	0.2709	0.3209
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0482	0.844	1
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Leishmania major	protein kinase, putative	0.0195	0	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0287	0.2709	0.3209
Echinococcus granulosus	tyrosine protein kinase Srms	0.0482	0.844	1
Loa Loa (eye worm)	hypothetical protein	0.0482	0.844	1
Loa Loa (eye worm)	hypothetical protein	0.0287	0.2709	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Loa Loa (eye worm)	TK protein kinase	0.0482	0.844	1
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0287	0.2709	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Echinococcus multilocularis	SH2 motif	0.0287	0.2709	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0482	0.844	1
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0482	0.844	1
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0482	0.844	0.844
Brugia malayi	Variant SH3 domain containing protein	0.0287	0.2709	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Brugia malayi	Tensin	0.0287	0.2709	0.3209
Brugia malayi	SH2 domain containing protein	0.0287	0.2709	0.3209
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0482	0.844	1
Schistosoma mansoni	tensin	0.0287	0.2709	0.2709
Plasmodium falciparum	protein kinase, putative	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Onchocerca volvulus		0.0482	0.844	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0287	0.2709	0.3209
Trichomonas vaginalis	conserved hypothetical protein	0.0195	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0287	0.2709	0.3209
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0195	0	0.5
Echinococcus multilocularis	signal transduction protein lnk realted	0.0287	0.2709	0.3209
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0287	0.2709	0.3209
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0287	0.2709	0.2709
Brugia malayi	Protein kinase domain containing protein	0.0482	0.844	1
Echinococcus granulosus	SH2 domain containing protein 7	0.0287	0.2709	0.3209
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0482	0.844	1
Loa Loa (eye worm)	SRC-1	0.0482	0.844	1
Brugia malayi	Sex muscle abnormal protein 5	0.0287	0.2709	0.3209
Echinococcus granulosus	tyrosine protein kinase Blk	0.0482	0.844	1
Trichomonas vaginalis	conserved hypothetical protein	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0287	0.2709	0.3209
Schistosoma mansoni	signal transduction protein lnk-related	0.0287	0.2709	0.2709
Trichomonas vaginalis	conserved hypothetical protein	0.0195	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0195	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0482	0.844	0.844
Echinococcus granulosus	signal transduction protein lnk realted	0.0287	0.2709	0.3209
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0287	0.2709	0.2709
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0287	0.2709	0.3209
Onchocerca volvulus		0.0482	0.844	1
Trypanosoma cruzi	protein kinase, putative	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0287	0.2709	0.3209
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0482	0.844	1
Entamoeba histolytica	SH2 domain containing protein	0.0287	0.2709	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0482	0.844	1
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0482	0.844	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0482	0.844	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0287	0.2709	0.2709
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0482	0.844	1
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0482	0.844	1
Onchocerca volvulus		0.0482	0.844	1
Loa Loa (eye worm)	hypothetical protein	0.0287	0.2709	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Brugia malayi	SH2 domain containing protein	0.0287	0.2709	0.3209
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0195	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0482	0.844	1
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Brugia malayi	SH2 domain containing protein	0.0287	0.2709	0.3209
Trichomonas vaginalis	conserved hypothetical protein	0.0195	0	0.5
Leishmania major	protein kinase, putative	0.0195	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0287	0.2709	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0195	0	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0195	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0287	0.2709	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Plasmodium vivax	protein kinase, putative	0.0195	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0287	0.2709	0.3209
Loa Loa (eye worm)	hypothetical protein	0.0287	0.2709	0.3209
Echinococcus granulosus	tensin	0.0287	0.2709	0.3209
Echinococcus multilocularis	tensin	0.0287	0.2709	0.3209
Schistosoma mansoni	tyrosine kinase	0.0482	0.844	0.844
Brugia malayi	RhoGAP domain containing protein	0.0287	0.2709	0.3209
Giardia lamblia	Kinase, NEK	0.0195	0	0.5
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0195	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0482	0.844	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0482	0.844	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0482	0.844	1
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0195	0	0.5
Brugia malayi	SH2 domain containing protein	0.0287	0.2709	0.3209
Schistosoma mansoni	nck2/grb4	0.0287	0.2709	0.2709
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Onchocerca volvulus		0.0482	0.844	1
Brugia malayi	Variant SH3 domain containing protein	0.0287	0.2709	0.3209
Loa Loa (eye worm)	SH2 domain-containing protein	0.0287	0.2709	0.3209
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0482	0.844	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0287	0.2709	0.3209
Brugia malayi	Variant SH3 domain containing protein	0.0287	0.2709	0.3209
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0287	0.2709	0.3209
Schistosoma mansoni	suppressor of cytokine signaling	0.0287	0.2709	0.2709
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0195	0	0.5
Echinococcus granulosus	SH2 motif	0.0287	0.2709	0.3209
Onchocerca volvulus		0.0287	0.2709	0.3209
Echinococcus multilocularis	NCK adaptor protein	0.0287	0.2709	0.3209
Schistosoma mansoni	tyrosine kinase	0.0482	0.844	0.844
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0482	0.844	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0287	0.2709	0.3209
Echinococcus granulosus	expressed conserved protein	0.0287	0.2709	0.3209
Brugia malayi	hypothetical protein	0.0482	0.844	1
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Onchocerca volvulus		0.0287	0.2709	0.3209
Brugia malayi	SRC-1	0.0482	0.844	1
Schistosoma mansoni	tyrosine kinase	0.0482	0.844	0.844
Schistosoma mansoni	tensin-related	0.0287	0.2709	0.2709
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0287	0.2709	0.3209
Trichomonas vaginalis	conserved hypothetical protein	0.0195	0	0.5
Onchocerca volvulus		0.0482	0.844	1
Echinococcus granulosus	tyrosine kinase	0.0482	0.844	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0287	0.2709	0.3209
Schistosoma mansoni	hypothetical protein	0.0287	0.2709	0.2709
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0287	0.2709	0.3209
Echinococcus granulosus	growth factor receptor bound protein 2	0.0287	0.2709	0.3209
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0482	0.844	1
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Schistosoma mansoni	tensin-related	0.0287	0.2709	0.2709
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Echinococcus multilocularis	N chimaerin	0.0287	0.2709	0.3209
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0482	0.844	1
Plasmodium falciparum	protein kinase, putative	0.0195	0	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0287	0.2709	0.2709
Loa Loa (eye worm)	SH2 domain-containing protein	0.0287	0.2709	0.3209
Entamoeba histolytica	protein kinase, putative	0.0287	0.2709	0.3209
Schistosoma mansoni	growth factor receptor-bound protein	0.0287	0.2709	0.2709
Echinococcus granulosus	N chimaerin	0.0287	0.2709	0.3209
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0482	0.844	1
Echinococcus granulosus	tyrosine kinase	0.0482	0.844	1
Giardia lamblia	Protein 21.1	0.0195	0	0.5
Schistosoma mansoni	tensin	0.0287	0.2709	0.2709
Brugia malayi	SH2 domain containing protein	0.0482	0.844	1
Loa Loa (eye worm)	hypothetical protein	0.0287	0.2709	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0287	0.2709	0.3209
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0287	0.2709	0.3209
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0195	0	0.5
Echinococcus multilocularis	SH2 domain containing protein 7	0.0287	0.2709	0.3209
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0482	0.844	1
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Echinococcus multilocularis		0.0287	0.2709	0.3209
Loa Loa (eye worm)	SH2 domain-containing protein	0.0287	0.2709	0.3209
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0195	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0195	0	0.5
Echinococcus multilocularis	tyrosine kinase	0.0482	0.844	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0482	0.844	1
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0287	0.2709	0.3209
Loa Loa (eye worm)	hypothetical protein	0.0287	0.2709	0.3209
Trypanosoma cruzi	protein kinase, putative	0.0195	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0482	0.844	1
Brugia malayi	SH2 domain containing protein	0.0287	0.2709	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Schistosoma mansoni	shc transforming protein	0.0287	0.2709	0.2709
Brugia malayi	Protein kinase domain containing protein	0.0482	0.844	1
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Trichomonas vaginalis	TK family protein kinase	0.0195	0	0.5
Brugia malayi	protein-tyrosine kinase	0.0482	0.844	1
Loa Loa (eye worm)	hypothetical protein	0.0287	0.2709	0.3209
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0287	0.2709	0.3209
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0287	0.2709	0.3209
Loa Loa (eye worm)	hypothetical protein	0.0287	0.2709	0.3209
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0287	0.2709	0.3209
Loa Loa (eye worm)	TK/FER protein kinase	0.0482	0.844	1
Onchocerca volvulus		0.0287	0.2709	0.3209
Echinococcus granulosus	SH2 motif	0.0287	0.2709	0.3209
Plasmodium falciparum	tyrosine kinase-like protein	0.0195	0	0.5
Brugia malayi	hypothetical protein	0.0287	0.2709	0.3209
Echinococcus granulosus	tyrosine protein kinase shark	0.0482	0.844	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0287	0.2709	0.3209
Trypanosoma brucei	protein kinase, putative	0.0195	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0482	0.844	1
Giardia lamblia	Kinase, NEK	0.0195	0	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0287	0.2709	0.3209
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0287	0.2709	0.3209
Schistosoma mansoni	adapter molecule crk	0.0287	0.2709	0.2709
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0482	0.844	1
Brugia malayi	Protein kinase domain containing protein	0.0482	0.844	1
Schistosoma mansoni	GTPase activating protein	0.0287	0.2709	0.2709
Loa Loa (eye worm)	TK/FER protein kinase	0.0482	0.844	1
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Toxoplasma gondii	protein kinase	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Onchocerca volvulus		0.0482	0.844	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0482	0.844	1
Loa Loa (eye worm)	hypothetical protein	0.0287	0.2709	0.3209
Echinococcus granulosus	c src tyrosine kinase	0.0482	0.844	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0287	0.2709	0.3209
Loa Loa (eye worm)	hypothetical protein	0.0287	0.2709	0.3209
Onchocerca volvulus		0.0287	0.2709	0.3209
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0482	0.844	1
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Onchocerca volvulus		0.0287	0.2709	0.3209
Echinococcus granulosus	NCK adaptor protein	0.0287	0.2709	0.3209
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0195	0	0.5
Schistosoma mansoni	SH2A	0.0287	0.2709	0.2709
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0195	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0482	0.844	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0482	0.844	1
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0195	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0482	0.844	1
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0287	0.2709	0.2709
Onchocerca volvulus		0.0287	0.2709	0.3209
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0482	0.844	1
Echinococcus multilocularis	SH2 motif	0.0287	0.2709	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0287	0.2709	0.2709
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0195	0	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0195	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0482	0.844	1
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0287	0.2709	0.3209
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0482	0.844	1
Loa Loa (eye worm)	STAT protein	0.0287	0.2709	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0482	0.844	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0287	0.2709	0.3209
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0287	0.2709	0.3209
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0482	0.844	1
Trichomonas vaginalis	AGC family protein kinase	0.0195	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0195	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0287	0.2709	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Schistosoma mansoni	hypothetical protein	0.0287	0.2709	0.2709
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0482	0.844	1
Trichomonas vaginalis	STE family protein kinase	0.0195	0	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0195	0	0.5
Leishmania major	hypothetical protein, conserved	0.0195	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0482	0.844	1
Echinococcus multilocularis	SH2 motif	0.0287	0.2709	0.3209
Schistosoma mansoni	tyrosine kinase	0.0482	0.844	0.844
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0287	0.2709	0.3209
Trichomonas vaginalis	TKL family protein kinase	0.0195	0	0.5
Echinococcus granulosus	SHC transforming protein 3	0.0287	0.2709	0.3209
Brugia malayi	SH2 domain containing protein	0.0482	0.844	1
Trichomonas vaginalis	CAMK family protein kinase	0.0195	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 110 nM	Inhibition of BACE1 in HEK293 cells expressing wild type APP assessed as level of amyloid beta (1 to 40) after 48 hrs by HTRF assay	ChEMBL.	23537249
IC50 (binding)	= 145 nM	Inhibition of human recombinant BACE1 expressed in CHO cells using biotin-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu peptide as substrate incubated for 15 mins prior to substrate addition measured after 2 hrs by HTRF assay	ChEMBL.	23537249
IC50 (binding)	= 6760 nM	Inhibition of human spleen cathepsin D using 5-FAM/QXL as peptide substrate after 1 hr by FRET assay	ChEMBL.	23537249

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2349606

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1754101