Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | serine/threonine kinase 12 | 0.0241 | 1 | 1 |
Echinococcus granulosus | aurora kinase A | 0.0241 | 1 | 1 |
Brugia malayi | hexokinase | 0.0096 | 0.3115 | 0.3115 |
Onchocerca volvulus | 0.0096 | 0.3115 | 1 | |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0241 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0241 | 1 | 1 |
Toxoplasma gondii | aurora kinase | 0.0241 | 1 | 1 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0241 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0241 | 1 | 1 |
Echinococcus multilocularis | aurora kinase A | 0.0241 | 1 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0241 | 1 | 1 |
Onchocerca volvulus | 0.0096 | 0.3115 | 1 | |
Entamoeba histolytica | protein kinase, putative | 0.0241 | 1 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0241 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0241 | 1 | 0.5 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0241 | 1 | 1 |
Trypanosoma brucei | aurora B kinase | 0.0241 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0241 | 1 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.0241 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.1663 | 0.1663 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0241 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.006 | 0.1413 | 0.1413 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 0.3115 | 0.5 |
Entamoeba histolytica | protein kinase , putative | 0.0241 | 1 | 1 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0241 | 1 | 1 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0241 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0241 | 1 | 0.5 |
Leishmania major | protein kinase, putative | 0.0241 | 1 | 1 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0241 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0241 | 1 | 1 |
Onchocerca volvulus | 0.0096 | 0.3115 | 1 | |
Trichomonas vaginalis | AGC family protein kinase | 0.0241 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.3115 | 0.3115 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 0.3115 | 0.3115 |
Loa Loa (eye worm) | AUR protein kinase | 0.0241 | 1 | 1 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0241 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0096 | 0.3115 | 0.3115 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.3115 | 0.3115 |
Giardia lamblia | Aurora kinase | 0.0241 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.006 | 0.1413 | 0.1413 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0241 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.