Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | prolyl oligopeptidase | 0.07 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0242 | 0.2893 | 0.2893 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0055 | 0 | 0.5 |
Toxoplasma gondii | PAN domain-containing protein | 0.0684 | 0.9751 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.07 | 1 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0235 | 0.2791 | 1 |
Onchocerca volvulus | 0.0059 | 0.0058 | 0.0058 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.1376 | 0.1376 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0055 | 0 | 0.5 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0235 | 0.2791 | 1 |
Brugia malayi | Trypsin family protein | 0.0242 | 0.2893 | 0.2893 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0242 | 0.2893 | 0.2893 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0055 | 0 | 0.5 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0235 | 0.2791 | 0.2791 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.2893 | 0.2893 |
Mycobacterium tuberculosis | Probable peptidase | 0.0055 | 0 | 0.5 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0235 | 0.2791 | 0.2791 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0059 | 0.0058 | 0.0058 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0055 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0055 | 0 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0059 | 0.0058 | 0.006 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.07 | 1 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0059 | 0.0058 | 1 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0055 | 0 | 0.5 |
Onchocerca volvulus | 0.0204 | 0.2308 | 0.2308 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0059 | 0.0058 | 0.0209 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.07 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0059 | 0.0058 | 0.0209 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0235 | 0.2791 | 0.2791 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0055 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.1376 | 0.1376 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0235 | 0.2791 | 0.2862 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.07 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0059 | 0.0058 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0058 | 0.0058 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0059 | 0.0058 | 0.0058 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0055 | 0 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0235 | 0.2791 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0059 | 0.0058 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0235 | 0.2791 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0055 | 0 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0055 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.2893 | 0.2893 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.1376 | 0.1376 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.193 | 0.193 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0235 | 0.2791 | 1 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0055 | 0 | 0.5 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0235 | 0.2791 | 0.2791 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0055 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0059 | 0.0058 | 0.0058 |
Toxoplasma gondii | PAN domain-containing protein | 0.0684 | 0.9751 | 1 |
Brugia malayi | hypothetical protein | 0.018 | 0.193 | 0.193 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0055 | 0 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0059 | 0.0058 | 0.0058 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0055 | 0 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0059 | 0.0058 | 0.0058 |
Onchocerca volvulus | 0.0242 | 0.2893 | 0.2893 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.