Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Cryptosporidium parvum | inosine-5-monophosphate dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0232075 | 0.701835 | 0.5 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0102881 | 0.243648 | 0.347159 |
Loa Loa (eye worm) | NHE-3 | 0.00377644 | 0.0127136 | 0.0181149 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0227259 | 0.684756 | 0.5 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0232075 | 0.701835 | 1 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0232075 | 0.701835 | 1 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0227259 | 0.684756 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00377644 | 0.0127136 | 0.0181149 |
Brugia malayi | Cytochrome P450 family protein | 0.00410903 | 0.0245087 | 0.0349208 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0232075 | 0.701835 | 0.701835 |
Brugia malayi | sodium/hydrogen exchanger 3 family protein | 0.00377644 | 0.0127136 | 0.0181149 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.00410903 | 0.0245087 | 0.0349208 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.00377644 | 0.0127136 | 0.0127136 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0232075 | 0.701835 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.00377644 | 0.0127136 | 0.0127136 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0102881 | 0.243648 | 0.347159 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.00377644 | 0.0127136 | 0.0127136 |
Toxoplasma gondii | IMP dehydrogenas | 0.0232075 | 0.701835 | 0.5 |
Brugia malayi | GMP reductase | 0.0102881 | 0.243648 | 0.347159 |
Schistosoma mansoni | sodium/hydrogen exchanger 2 (nhe2) | 0.00377644 | 0.0127136 | 0.0127136 |
Leishmania major | guanosine monophosphate reductase | 0.0232075 | 0.701835 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 (nhe2) | 0.00355087 | 0.00471384 | 0.00471384 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.00377644 | 0.0127136 | 0.0127136 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.00377644 | 0.0127136 | 0.0127136 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0232075 | 0.701835 | 0.5 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0232075 | 0.701835 | 0.701835 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0232075 | 0.701835 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.00377644 | 0.0127136 | 0.0127136 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.00377644 | 0.0127136 | 0.0127136 |
Loa Loa (eye worm) | hypothetical protein | 0.00377644 | 0.0127136 | 0.0181149 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0232075 | 0.701835 | 0.5 |
Loa Loa (eye worm) | GMP reductase | 0.0102881 | 0.243648 | 0.347159 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.00377644 | 0.0127136 | 0.0127136 |
Schistosoma mansoni | neuropeptide receptor | 0.0316148 | 1 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.00377644 | 0.0127136 | 0.0127136 |
Echinococcus multilocularis | neuropeptide receptor | 0.0316148 | 1 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.00377644 | 0.0127136 | 0.0127136 |
Loa Loa (eye worm) | sodium/hydrogen exchanger 3 family protein | 0.00377644 | 0.0127136 | 0.0181149 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0227259 | 0.684756 | 0.961281 |
Loa Loa (eye worm) | sodium/hydrogen exchanger | 0.00377644 | 0.0127136 | 0.0181149 |
Trypanosoma cruzi | GMP reductase | 0.0232075 | 0.701835 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.0232075 | 0.701835 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0124378 | 0.319889 | 0.13412 |
Schistosoma mansoni | sodium/hydrogen exchanger | 0.00377644 | 0.0127136 | 0.0127136 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0232075 | 0.701835 | 0.701835 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.00355087 | 0.00471384 | 0.00471384 |
Echinococcus granulosus | neuropeptide receptor | 0.0316148 | 1 | 1 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0232075 | 0.701835 | 1 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0316148 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0232075 | 0.701835 | 0.5 |
Giardia lamblia | Sodium/hydrogen exchanger 3 | 0.00377644 | 0.0127136 | 0.5 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0232075 | 0.701835 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0232075 | 0.701835 | 1 |
Trypanosoma brucei | GMP reductase | 0.0232075 | 0.701835 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00377644 | 0.0127136 | 0.0181149 |
Onchocerca volvulus | Putative GMP reductase | 0.0102881 | 0.243648 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2.5 uM | Antiparasitic activity against transgenic Toxoplasma gondii expressing Cryptosporidium parvum IMPDH | ChEMBL. | 23668331 |
IC50 (functional) | = | AntiToxoplasma gondii activity data 2-day killing assay: IC50 (uM), Experiment F | ChEMBL. | No reference |
IC50 (functional) | = | AntiToxoplasma gondii activity data 2-day killing assay: IC50 (uM), Experiment G | ChEMBL. | No reference |
IC50 (binding) | = 120 nM | Inhibition of Cryptosporidium parvum N-terminal His6-tagged IMPDH-mediated NADH production expressed in Escherichia coli BL21(DE3) preincubated for 5 mins prior to substrate addition by fluorescence assay | ChEMBL. | 23668331 |
IC50 (binding) | = 130 nM | Inhibition of Cryptosporidium parvum N-terminal His6-tagged IMPDH-mediated NADH production expressed in Escherichia coli BL21(DE3) preincubated for 5 mins prior to substrate addition by fluorescence assay in presence of BSA | ChEMBL. | 23668331 |
IC50 (binding) | > 5 uM | Inhibition of human IMPDH2 | ChEMBL. | 23668331 |
Inhibition (binding) | Compound was evaluated for the inhibition of human FECH at 10uM | MMV_PBOX. | No reference | |
Inhibition (functional) | = 3.75 % | AntiToxoplasma gondii activity data 2-day killing assay: inhibition at 10 uM (%) Experiment C | ChEMBL. | No reference |
Inhibition (functional) | ~ 75 % | AntiToxoplasma gondii activity data Inhibition of plaque forming efficiency (%) Experiment B | ChEMBL. | No reference |
Inhibition (functional) | = 100 % | AntiToxoplasma gondii activity data Inhibition of plaque forming efficiency (%) Experiment A | ChEMBL. | No reference |
Inhibition (functional) | = 1.05 uM | AntiToxoplasma gondii activity data 2-day killing assay: inhibition at 10 uM (%) Experiment E | ChEMBL. | No reference |
Inhibition (functional) | = 62.59 uM | AntiToxoplasma gondii activity data 2-day killing assay: inhibition at 10 uM (%) Experiment D | ChEMBL. | No reference |
Ratio EC50 (functional) | = 1.9 | Selectivity ratio of EC50 for wild-type Toxoplasma gondii to EC50 for Toxoplasma gondii expressing Cryptosporidium parvum IMPDH | ChEMBL. | 23668331 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Toxoplasma gondii | ChEMBL23 | 23668331 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.