Detailed information for compound 17567

Basic information

Technical information
  • TDR Targets ID: 17567
  • Name: 2-(butan-2-ylamino)-1-(5,6,7,8-tetrahydronaph thalen-2-yl)ethanol hydrochloride
  • MW: 283.837 | Formula: C16H26ClNO
  • H donors: 2 H acceptors: 1 LogP: 4.15 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(NCC(c1ccc2c(c1)CCCC2)O)C.Cl
  • InChi: 1S/C16H25NO.ClH/c1-3-12(2)17-11-16(18)15-9-8-13-6-4-5-7-14(13)10-15;/h8-10,12,16-18H,3-7,11H2,1-2H3;1H
  • InChiKey: KHBXORBAOCQNMC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(sec-butylamino)-1-tetralin-6-yl-ethanol hydrochloride
  • 2-(sec-butylamino)-1-(6-tetralinyl)ethanol hydrochloride
  • butan-2-yl-[2-hydroxy-2-(5,6,7,8-tetrahydronaphthalen-2-yl)ethyl]azanium chloride
  • (2-hydroxy-2-tetralin-6-yl-ethyl)-sec-butyl-ammonium chloride
  • [2-hydroxy-2-(6-tetralinyl)ethyl]-sec-butylammonium chloride
  • (R,S)-2-sec-Butylamino-(5,6,7,8-tetrahydro-2-naphthyl)ethanol hydrochloride
  • 2-Naphthalenemethanol, 5,6,7,8-tetrahydro-alpha-((sec-butylamino)methyl)-, hydrochloride, (R,S)-
  • QJ9388000
  • (S,R)-2-sec-Butylamino-(5,6,7,8-tetrahydro-2-naphthyl)ethanol hydrochloride
  • 2-Naphthalenemethanol, 5,6,7,8-tetrahydro-alpha-((sec-butylamino)methyl)-, hydrochloride, (S,R)-
  • QJ9390000
  • 1506-12-3
  • 5803-79-2
  • 2-NAPHTHALENEMETHANOL, 5,6,7,8-TETRAHYDRO-alpha-((sec-BUTYLAMINO)METHYL)-, HYDRO
  • 2-Naphthalenemethanol, 5,6,7,8-tetrahydro-alpha-((sec-butylamino)methyl)-, hydrochloride
  • 2-sec-Butylamino-1-(5,6,7,8-tetrahydro-2-naphthyl)-ethanol hydrochloride
  • 5,6,7,8-Tetrahydro-alpha-(((1-methylpropyl)amino)methyl)-2-naphthalenemethanol hydrochloride
  • Betabloc
  • Butidrine
  • Butidrine hydrochloride
  • Butyridine hydrochloride
  • Recetan
  • (R,R)-2-sec-Butylamino-(5,6,7,8-tetrahydro-2-naphthyl)ethanol hydrochloride
  • 2-Naphthalenemethanol, 5,6,7,8-tetrahydro-alpha-((sec-butylamino)methyl)-, hydrochloride, (R,R)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0024 0.7676 0.7676
Echinococcus multilocularis calcium activated potassium channel 0.0024 0.7676 0.7676
Echinococcus multilocularis lamin dm0 0.0028 1 1
Echinococcus granulosus lamin dm0 0.0028 1 1
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0024 0.7676 0.7411
Echinococcus granulosus hyperpolarization activated cyclic 0.0024 0.7676 0.7676
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0024 0.7676 0.7676
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0024 0.7676 0.7676
Echinococcus granulosus potassium voltage gated channel protein 0.0024 0.7676 0.7676
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0024 0.7676 0.7676
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676
Brugia malayi voltage-dependent calcium channel 0.0024 0.7676 0.7411
Echinococcus multilocularis transfer RNA-Gly 0.0024 0.7676 0.7676
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0024 0.7676 0.5
Toxoplasma gondii hypothetical protein 0.0024 0.7676 0.5
Echinococcus granulosus ryanodine receptor 44f 0.0024 0.7676 0.7676
Echinococcus granulosus voltage dependent calcium channel 0.0024 0.7676 0.7676
Echinococcus granulosus hypothetical protein 0.0024 0.7676 0.7676
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0024 0.7676 0.7676
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0024 0.7676 0.5
Echinococcus granulosus voltage dependent calcium channel 0.0024 0.7676 0.7676
Loa Loa (eye worm) ryanodine receptor 0.0024 0.7676 0.7676
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0024 0.7676 0.7676
Leishmania major hypothetical protein, conserved 0.0024 0.7676 0.5
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0024 0.7676 0.7676
Echinococcus multilocularis voltage gated potassium channel 0.0024 0.7676 0.7676
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0024 0.7676 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.0024 0.7676 0.7676
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0024 0.7676 0.7676
Schistosoma mansoni intermediate filament proteins 0.0028 1 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0024 0.7676 0.7676
Echinococcus granulosus voltage gated hydrogen channel 1 0.0024 0.7676 0.7676
Echinococcus multilocularis transient receptor potential cation channel 0.0024 0.7676 0.7676
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0024 0.7676 0.7411
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0024 0.7676 0.7676
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 1 1
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0024 0.7676 0.7676
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0024 0.7676 0.5
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0024 0.7676 0.7411
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0024 0.7676 0.7411
Echinococcus granulosus sodium channel protein 0.0024 0.7676 0.7676
Loa Loa (eye worm) voltage-gated calcium channel 0.0024 0.7676 0.7676
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0024 0.7676 0.7676
Echinococcus granulosus transient receptor potential gamma protein 0.0024 0.7676 0.7676
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0024 0.7676 0.7676
Echinococcus multilocularis hyperpolarization activated cyclic 0.0024 0.7676 0.7676
Echinococcus multilocularis short transient receptor potential channel 6 0.0024 0.7676 0.7676
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0024 0.7676 0.5
Loa Loa (eye worm) voltage-gated potassium channel 0.0024 0.7676 0.7676
Echinococcus multilocularis shaker cognate 0.0024 0.7676 0.7676
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0024 0.7676 0.5
Echinococcus multilocularis voltage gated potassium channel 0.0024 0.7676 0.7676
Echinococcus multilocularis short transient receptor potential channel 6 0.0024 0.7676 0.7676
Echinococcus multilocularis potassium voltage gated channel protein 0.0024 0.7676 0.7676
Brugia malayi ion channel NompC 0.0024 0.7676 0.7411
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0024 0.7676 0.7676
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0024 0.7676 0.7411
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0024 0.7676 0.7676
Echinococcus multilocularis potassium voltage gated channel protein 0.0024 0.7676 0.7676
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0024 0.7676 0.7411
Echinococcus granulosus short transient receptor potential channel 6 0.0024 0.7676 0.7676
Echinococcus multilocularis voltage dependent calcium channel 0.0024 0.7676 0.7676
Onchocerca volvulus 0.0028 1 1
Echinococcus multilocularis conserved hypothetical protein 0.0024 0.7676 0.7676
Echinococcus multilocularis transient receptor potential cation channel 0.0024 0.7676 0.7676
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0024 0.7676 0.7676
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0024 0.7676 0.7411
Echinococcus granulosus potassium voltage gated channel protein 0.0024 0.7676 0.7676
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0024 0.7676 0.7676
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676
Toxoplasma gondii transporter, cation channel family protein 0.0024 0.7676 0.5
Loa Loa (eye worm) calcium channel 0.0024 0.7676 0.7676
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0024 0.7676 0.7411
Echinococcus granulosus short transient receptor potential channel 6 0.0024 0.7676 0.7676
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0024 0.7676 0.7676
Schistosoma mansoni lamin 0.0028 1 1
Loa Loa (eye worm) voltage-dependent calcium channel 0.0024 0.7676 0.7676
Echinococcus granulosus voltage gated potassium channel 0.0024 0.7676 0.7676
Echinococcus granulosus transient receptor potential cation channel 0.0024 0.7676 0.7676
Echinococcus granulosus sodium leak channel non selective protein 0.0024 0.7676 0.7676
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676
Brugia malayi Transient-receptor-potential like protein 0.0024 0.7676 0.7411
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0024 0.7676 0.7676
Toxoplasma gondii hypothetical protein 0.0024 0.7676 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0024 0.7676 0.7676
Echinococcus granulosus transient receptor potential cation channel 0.0024 0.7676 0.7676
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.1026 0.1026
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0024 0.7676 0.7411
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676
Echinococcus multilocularis musashi 0.0028 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0024 0.7676 0.7676
Echinococcus granulosus potassium large conductance calcium activated 0.0024 0.7676 0.7676
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0024 0.7676 0.7676
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0024 0.7676 0.7676
Echinococcus granulosus potassium voltage gated channel protein 0.0024 0.7676 0.7676
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0024 0.7676 0.5
Echinococcus multilocularis sodium channel protein 0.0024 0.7676 0.7676
Toxoplasma gondii transporter, cation channel family protein 0.0024 0.7676 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.0024 0.7676 0.7676
Toxoplasma gondii transporter, cation channel family protein 0.0024 0.7676 0.5
Echinococcus granulosus transient receptor potential cation channel 0.0024 0.7676 0.7676
Brugia malayi Intermediate filament tail domain containing protein 0.0028 1 1
Echinococcus granulosus calcium activated potassium channel 0.0024 0.7676 0.7676
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0024 0.7676 0.7676
Echinococcus multilocularis sodium leak channel non selective protein 0.0024 0.7676 0.7676
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0024 0.7676 0.7676
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0024 0.7676 0.5
Echinococcus multilocularis transient receptor potential gamma protein 0.0024 0.7676 0.7676
Echinococcus multilocularis two pore calcium channel protein 2 0.0024 0.7676 0.7676
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0024 0.7676 0.7676
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0024 0.7676 0.7411
Brugia malayi cation channel family protein 0.0024 0.7676 0.7411
Echinococcus multilocularis transient receptor potential cation channel 0.0024 0.7676 0.7676
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676
Leishmania major hypothetical protein, unknown function 0.0024 0.7676 0.5
Echinococcus granulosus two pore calcium channel protein 1 0.0024 0.7676 0.7676
Loa Loa (eye worm) ion channel NompC 0.0024 0.7676 0.7676
Schistosoma mansoni lamin 0.0028 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0024 0.7676 0.7676
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0024 0.7676 0.5
Echinococcus granulosus intermediate filament protein 0.0028 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0024 0.7676 0.7411
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0024 0.7676 0.7411
Echinococcus granulosus shaker cognate 0.0024 0.7676 0.7676
Brugia malayi Cyclic-nucleotide gated cation channel 0.0024 0.7676 0.7411
Loa Loa (eye worm) hypothetical protein 0.0027 0.9646 0.9646
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0024 0.7676 0.7676
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0024 0.7676 0.7676
Echinococcus multilocularis transient receptor potential cation channel 0.0024 0.7676 0.7676
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0024 0.7676 0.7676
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0024 0.7676 0.7676
Echinococcus multilocularis hyperpolarization activated cyclic 0.0024 0.7676 0.7676
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0024 0.7676 0.7676
Echinococcus multilocularis potassium large conductance calcium activated 0.0024 0.7676 0.7676
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0024 0.7676 0.7411
Echinococcus granulosus transient receptor potential cation channel 0.0024 0.7676 0.7676
Loa Loa (eye worm) hypothetical protein 0.0028 1 1
Echinococcus granulosus two pore calcium channel protein 2 0.0024 0.7676 0.7676
Echinococcus multilocularis potassium voltage gated channel protein 0.0024 0.7676 0.7676
Echinococcus granulosus voltage gated potassium channel 0.0024 0.7676 0.7676
Loa Loa (eye worm) intermediate filament protein 0.0028 1 1
Echinococcus multilocularis voltage dependent calcium channel 0.0024 0.7676 0.7676
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676
Echinococcus granulosus TRP transient receptor potential channel 0.0024 0.7676 0.7676
Echinococcus granulosus transient receptor potential cation channel 0.0024 0.7676 0.7676
Loa Loa (eye worm) voltage-gated potassium channel 0.0024 0.7676 0.7676
Echinococcus granulosus lamin 0.0028 1 1
Echinococcus granulosus potassium voltage gated channel protein 0.0024 0.7676 0.7676
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0024 0.7676 0.7676
Brugia malayi hypothetical protein 0.0024 0.7676 0.7411
Echinococcus multilocularis lamin 0.0028 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0024 0.7676 0.7676
Brugia malayi cation channel family protein 0.0024 0.7676 0.7411
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0024 0.7676 0.7676
Echinococcus multilocularis ryanodine receptor 44f 0.0024 0.7676 0.7676
Echinococcus granulosus hyperpolarization activated cyclic 0.0024 0.7676 0.7676
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0024 0.7676 0.7676
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0024 0.7676 0.7411
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676
Echinococcus granulosus potassium voltage gated channel protein 0.0024 0.7676 0.7676
Echinococcus granulosus transient receptor potential cation channel 0.0024 0.7676 0.7676
Onchocerca volvulus 0.0028 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0024 0.7676 0.7676
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0024 0.7676 0.7676
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0024 0.7676 0.7411
Echinococcus multilocularis two pore calcium channel protein 1 0.0024 0.7676 0.7676
Brugia malayi olfactory channel protein osm-9 0.0024 0.7676 0.7411
Loa Loa (eye worm) hypothetical protein 0.0024 0.7676 0.7676

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) mg kg-1 Beta-adrenoceptor blocking potency was estimated in vivo by blockade of the isoproterenol tachycardia response in rat; ND means no data ChEMBL. 6102152
ED50 (functional) 0 mg kg-1 Beta-adrenoceptor blocking potency was estimated in vivo by blockade of the isoproterenol tachycardia response in rat; ND means no data ChEMBL. 6102152
ED50 (functional) = 1217 ug kg-1 Beta-adrenoceptor blocking potency in cat as dose causing 50% inhibition of the tachycardia produced by 0.2 ug/kg iv of isoproterenol ChEMBL. 6102152
ED50 (functional) = 1217 ug kg-1 Beta-adrenoceptor blocking potency in cat as dose causing 50% inhibition of the tachycardia produced by 0.2 ug/kg iv of isoproterenol ChEMBL. 6102152
Inhibition (functional) = 47 % Percentage inhibition of depressor response in cat was determined ChEMBL. 6102152

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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