Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lipase, hormone-sensitive | Starlite/ChEMBL | References |
Rattus norvegicus | Hormone-sensitive lipase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | lipoprotein LpqF | 0.1383 | 0.154 | 0.2454 |
Toxoplasma gondii | Acetyl-coenzyme A transporter, putative | 0.6203 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 0.0684 | 0.0684 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 0.0684 | 0.0684 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 0.0684 | 0.0684 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.5725 | 0.916 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 0.0684 | 0.0684 |
Trichomonas vaginalis | esterase, putative | 0.0896 | 0.0684 | 0.5 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.2882 | 0.417 | 1 |
Schistosoma mansoni | solute carrier family 33 (acetyl-CoA transporter | 0.6203 | 1 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0896 | 0.0684 | 0.0684 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.1383 | 0.154 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0896 | 0.0684 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0896 | 0.0684 | 0.0684 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0896 | 0.0684 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0896 | 0.0684 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 0.0684 | 0.0684 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0896 | 0.0684 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 0.0684 | 0.0684 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0896 | 0.0684 | 0.0684 |
Trypanosoma brucei | beta lactamase | 0.1383 | 0.154 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0896 | 0.0684 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0896 | 0.0684 | 0.5 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.1383 | 0.154 | 0.1009 |
Loa Loa (eye worm) | beta-lactamase | 0.0896 | 0.0684 | 0.0684 |
Schistosoma mansoni | solute carrier family 33 (acetyl-CoA transporter | 0.2306 | 0.3159 | 0.3159 |
Onchocerca volvulus | 0.0896 | 0.0684 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.6203 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0896 | 0.0684 | 0.5 |
Schistosoma mansoni | solute carrier family 33 (acetyl-CoA transporter | 0.6203 | 1 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0896 | 0.0684 | 0.0684 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0896 | 0.0684 | 0.0684 |
Brugia malayi | Protein C21B10.09 in chromosome II | 0.6203 | 1 | 1 |
Onchocerca volvulus | 0.0896 | 0.0684 | 0.5 | |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.2882 | 0.417 | 0.4113 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0896 | 0.0684 | 0.5 |
Echinococcus multilocularis | solute carrier family 33 | 0.6203 | 1 | 1 |
Onchocerca volvulus | 0.0896 | 0.0684 | 0.5 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0896 | 0.0684 | 0.5 |
Plasmodium falciparum | acetyl-CoA transporter, putative | 0.6203 | 1 | 0.5 |
Echinococcus granulosus | solute carrier family 33 | 0.6203 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6 nM | Inhibition of human recombinant hormone sensitive lipase (HSL) | ChEMBL. | 15149665 |
IC50 (binding) | = 6 nM | Inhibition of human recombinant hormone sensitive lipase (HSL) | ChEMBL. | 15149665 |
IC50 (binding) | = 6 nM | Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay | ChEMBL. | 18808096 |
IC50 (functional) | = 24 nM | Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells | ChEMBL. | 15149665 |
IC50 (functional) | = 24 nM | Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells | ChEMBL. | 15149665 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.