Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | proteasome subunit beta type-5 | 0.022 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.022 | 1 | 0.5 |
Onchocerca volvulus | 0.0142 | 0.4146 | 1 | |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.022 | 1 | 0.5 |
Mycobacterium ulcerans | proteasome PrcB | 0.022 | 1 | 0.5 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.022 | 1 | 1 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.022 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0142 | 0.4146 | 0.2234 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.022 | 1 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0142 | 0.4146 | 0.2234 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.022 | 1 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.022 | 1 | 0.5 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.022 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0142 | 0.4146 | 0.2234 |
Echinococcus granulosus | proteasome prosome macropain | 0.022 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.022 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.022 | 1 | 1 |
Onchocerca volvulus | 0.0119 | 0.2462 | 0.5938 | |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0142 | 0.4146 | 0.2234 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.4146 | 0.2234 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.022 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.022 | 1 | 0.5 |
Leishmania major | proteasome beta 5 subunit, putative | 0.022 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.022 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 60 ug ml-1 | Antifungal activity against Candida albicans NCIM 3471 by agar method | ChEMBL. | 23434418 |
MIC (functional) | = 100 ug ml-1 | Antibacterial activity against Escherichia coli NCIM 2256 by agar method | ChEMBL. | 23434418 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.