Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase kinase kinase 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | casein kinase 1, putative | 0.0087 | 0.0578 | 0.5 |
Entamoeba histolytica | casein kinase, putative | 0.0087 | 0.0578 | 0.5 |
Leishmania major | casein kinase, putative | 0.0087 | 0.0578 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.9919 | 1 |
Trypanosoma cruzi | casein kinase, putative | 0.0087 | 0.0578 | 1 |
Loa Loa (eye worm) | CK1/CK1/CK1-D protein kinase | 0.0087 | 0.0578 | 0.0583 |
Trypanosoma cruzi | casein kinase, putative | 0.0087 | 0.0578 | 1 |
Trichomonas vaginalis | CK1 family protein kinase | 0.0087 | 0.0578 | 0.5 |
Onchocerca volvulus | 0.0087 | 0.0578 | 1 | |
Loa Loa (eye worm) | CK1/CK1/CK1-A protein kinase | 0.0087 | 0.0578 | 0.0583 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0251 | 1 | 1 |
Trypanosoma cruzi | casein kinase, delta isoform, putative | 0.0087 | 0.0578 | 1 |
Trypanosoma cruzi | casein kinase, putative | 0.0087 | 0.0578 | 1 |
Trypanosoma cruzi | casein kinase, delta isoform, putative | 0.0085 | 0.0497 | 0.8594 |
Schistosoma mansoni | protein kinase | 0.0251 | 1 | 1 |
Toxoplasma gondii | casein kinase I | 0.0087 | 0.0578 | 0.5 |
Entamoeba histolytica | casein kinase 1, putative | 0.0087 | 0.0578 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0251 | 1 | 1 |
Giardia lamblia | Kinase, CK1 Casein kinase | 0.0087 | 0.0578 | 0.5 |
Trypanosoma cruzi | casein kinase, putative | 0.0087 | 0.0578 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0251 | 1 | 1 |
Loa Loa (eye worm) | CK1/CK1/CK1-A protein kinase | 0.0087 | 0.0578 | 0.0583 |
Trichomonas vaginalis | CK1 family protein kinase | 0.0087 | 0.0578 | 0.5 |
Trichomonas vaginalis | CK1 family protein kinase | 0.0087 | 0.0578 | 0.5 |
Trypanosoma brucei | casein kinase I, isoform 2 | 0.0087 | 0.0578 | 0.5 |
Plasmodium falciparum | casein kinase 1 | 0.0087 | 0.0578 | 0.5 |
Trypanosoma cruzi | casein kinase, putative | 0.0087 | 0.0578 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 2.5 % | Inhibition of human ASK1 using MBP as substrate assessed as residual activity at 10 uM incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis | ChEMBL. | 23041041 |
Activity (binding) | = 22 % | Inhibition of human FGFR1 using IGF-IRtide (12 to 527) as substrate assessed as residual activity at 10 uM incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis | ChEMBL. | 23041041 |
Activity (binding) | = 32 % | Inhibition of human HGFR using KKKSPGEYVNIEFG as substrate assessed as residual activity at 10 uM incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis | ChEMBL. | 23041041 |
Activity (binding) | = 39 % | Inhibition of human Aurora A using Kemptide as substrate assessed as residual activity at 10 uM incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis | ChEMBL. | 23041041 |
Activity (binding) | = 44 % | Inhibition of human Tie2 using TK substrate 2 as substrate assessed as residual activity at 10 uM incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis | ChEMBL. | 23041041 |
Activity (binding) | = 56 % | Inhibition of human CK2 using RRRDDDSDDD as substrate assessed as residual activity at 10 uM incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis | ChEMBL. | 23041041 |
Activity (binding) | = 87 % | Inhibition of human JNK3 using JNK3tide as substrate assessed as residual activity at 10 uM incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis | ChEMBL. | 23041041 |
IC50 (binding) | = 0.3 uM | Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis | ChEMBL. | 23041041 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.