TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 497.554 | Formula: C24H34F3N5O3
H donors: 1 H acceptors: 4 LogP: 1.9 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@@H](N1C[C@@H](C)[C@@H](OCc2n(CCCC1=O)nnc2)CN(Cc1cccc(c1)C(F)(F)F)C)C
InChi: 1S/C24H34F3N5O3/c1-17-12-31(18(2)15-33)23(34)8-5-9-32-21(11-28-29-32)16-35-22(17)14-30(3)13-19-6-4-7-20(10-19)24(25,26)27/h4,6-7,10-11,17-18,22,33H,5,8-9,12-16H2,1-3H3/t17-,18+,22+/m1/s1
InChiKey: DXNYPMFBKGSJNE-FGSXEWAUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0064	0.0531	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0423	0.5151
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0064	0.0531	0.7157
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0423	0.0339
Echinococcus granulosus	hypothetical protein	0.0064	0.0531	0.7771
Echinococcus multilocularis	serotonin receptor	0.0064	0.0531	0.7771
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0064	0.0531	0.0447
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0423	0.6199
Trypanosoma cruzi	hypothetical protein, conserved	0.0104	0.1017	0.0937
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0033	0.0148	0.216
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0064	0.0531	0.7157
Schistosoma mansoni	biogenic amine receptor	0.0064	0.0531	0.7157
Schistosoma mansoni	neuropeptide receptor	0.0064	0.0531	0.7157
Brugia malayi	putative neuropeptide receptor	0.0064	0.0531	0.0447
Schistosoma mansoni	hypothetical protein	0.0064	0.0531	0.7157
Echinococcus granulosus	neuropeptide Y receptor	0.0064	0.0531	0.7771
Echinococcus granulosus	dro:myosuppressin receptor	0.0064	0.0531	0.7771
Brugia malayi	putative neuropeptide receptor NPR1	0.0064	0.0531	0.0447
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0064	0.0531	0.7771
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0033	0.0148	0.216
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0683	1
Echinococcus multilocularis	allatostatin A receptor	0.0064	0.0531	0.7771
Schistosoma mansoni	opsin-like receptor	0.0064	0.0531	0.7157
Brugia malayi	GnHR receptor homolog	0.0064	0.0531	0.0447
Schistosoma mansoni	histamine h1 receptor	0.0064	0.0531	0.7157
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0064	0.0531	0.7771
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Schistosoma mansoni	amine GPCR	0.0064	0.0531	0.7157
Echinococcus multilocularis	neuropeptide receptor	0.0064	0.0531	0.7771
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0064	0.0531	0.7157
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0064	0.0531	0.7157
Echinococcus multilocularis	g protein coupled receptor	0.0064	0.0531	0.7771
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0064	0.0531	0.5
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Schistosoma mansoni	biogenic amine receptor	0.0064	0.0531	0.7157
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0064	0.0531	0.7771
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0064	0.0531	0.7771
Trypanosoma cruzi	inosine-adenosine-guanosine-nucleosidehydrolase, putative	0.0504	0.5902	0.5866
Schistosoma mansoni	neuropeptide receptor	0.0064	0.0531	0.7157
Schistosoma mansoni	neuropeptide F-like receptor	0.0064	0.0531	0.7157
Onchocerca volvulus		0.0064	0.0531	0.5
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0423	0.0339
Loa Loa (eye worm)	neuropeptide F receptor	0.0064	0.0531	0.0447
Trypanosoma brucei	inosine-guanine nucleoside hydrolase	0.0133	0.1378	0.1302
Echinococcus multilocularis	g-protein coupled receptor	0.0064	0.0531	0.7771
Echinococcus granulosus	biogenic amine 5HT receptor	0.0064	0.0531	0.7771
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0064	0.0531	0.7157
Onchocerca volvulus		0.0064	0.0531	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0683	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0064	0.0531	0.7771
Schistosoma mansoni	amine GPCR	0.0064	0.0531	0.7157
Trypanosoma brucei	C-8 sterol isomerase, putative	0.084	1	1
Schistosoma mansoni	amine GPCR	0.0064	0.0531	0.7157
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0064	0.0531	0.7157
Echinococcus granulosus	sex peptide receptor	0.0064	0.0531	0.7771
Giardia lamblia	Hypothetical protein	0.0133	0.1378	0.5
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0064	0.0531	0.7771
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0064	0.0531	0.7771
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0064	0.0531	0.7771
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0064	0.0531	0.7771
Brugia malayi	hypothetical protein	0.0064	0.0531	0.0447
Echinococcus granulosus	serotonin receptor	0.0064	0.0531	0.7771
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0423	0.5151
Brugia malayi	G-protein coupled receptor	0.0064	0.0531	0.0447
Schistosoma mansoni	opsin-like receptor	0.0064	0.0531	0.7157
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Entamoeba histolytica	Inosine-uridine preferring nucleoside hydrolase, putative	0.0133	0.1378	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0064	0.0531	0.7771
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0064	0.0531	0.7157
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0064	0.0531	0.0447
Brugia malayi	hypothetical protein	0.0064	0.0531	0.0447
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0064	0.0531	0.7771
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0683	1
Echinococcus multilocularis	neuropeptide s receptor	0.0064	0.0531	0.7771
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0064	0.0531	0.7157
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0064	0.0531	0.7157
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0064	0.0531	0.7771
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0064	0.0531	0.7771
Schistosoma mansoni	neuropeptide receptor	0.0064	0.0531	0.7157
Echinococcus multilocularis	serotonin receptor	0.0064	0.0531	0.7771
Brugia malayi	Dopamine receptor protein 2	0.0064	0.0531	0.0447
Onchocerca volvulus		0.0064	0.0531	0.5
Brugia malayi	Dopamine receptor	0.0064	0.0531	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Echinococcus granulosus	orexin receptor type 2	0.0064	0.0531	0.7771
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Echinococcus granulosus	neuropeptides capa receptor	0.0064	0.0531	0.7771
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Echinococcus multilocularis	neuropeptides capa receptor	0.0064	0.0531	0.7771
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Loa Loa (eye worm)	hypothetical protein	0.084	1	1
Brugia malayi	Serotonin receptor	0.0064	0.0531	0.0447
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0064	0.0531	0.7157
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0064	0.0531	0.7771
Echinococcus multilocularis	sex peptide receptor	0.0064	0.0531	0.7771
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Echinococcus multilocularis	neuropeptide receptor	0.0064	0.0531	0.7771
Trypanosoma brucei	inosine-adenosine-guanosine-nucleosidehydrolase	0.0504	0.5902	0.5866
Echinococcus granulosus	allatostatin A receptor	0.0064	0.0531	0.7771
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Onchocerca volvulus		0.0064	0.0531	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0064	0.0531	0.7771
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0064	0.0531	0.7157
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0064	0.0531	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Echinococcus multilocularis	neuropeptide Y receptor	0.0064	0.0531	0.7771
Trichomonas vaginalis	inosine-uridine preferring nucleoside hydrolase, putative	0.0133	0.1378	1
Brugia malayi	Glutamate receptor 1 precursor	0.0033	0.0148	0.0061
Echinococcus granulosus	rhodopsin orphan GPCR	0.0064	0.0531	0.7771
Echinococcus multilocularis	orexin receptor type 2	0.0064	0.0531	0.7771
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0064	0.0531	0.7771
Echinococcus granulosus	neuropeptide s receptor	0.0064	0.0531	0.7771
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0683	0.0601
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Brugia malayi	TAR-binding protein	0.0076	0.0683	0.0601
Leishmania major	inosine-guanine nucleoside hydrolase, putative	0.0133	0.1378	0.1302
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0064	0.0531	0.7157
Onchocerca volvulus		0.0064	0.0531	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0064	0.0531	0.7771
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0683	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0064	0.0531	0.0447
Brugia malayi	hypothetical protein	0.0064	0.0531	0.0447
Trichomonas vaginalis	inosine-uridine preferring nucleoside hydrolase, putative	0.0133	0.1378	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0064	0.0531	0.7771
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0064	0.0531	0.0447
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0033	0.0148	0.216
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0683	1
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Onchocerca volvulus		0.0064	0.0531	0.5
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Echinococcus granulosus	glutamate receptor 2	0.0033	0.0148	0.216
Schistosoma mansoni	neuropeptide f receptor 76f	0.0064	0.0531	0.7157
Echinococcus multilocularis	g protein coupled receptor	0.0064	0.0531	0.7771
Onchocerca volvulus		0.0064	0.0531	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0064	0.0531	0.7771
Echinococcus granulosus	7TM GPCR rhodopsin	0.0064	0.0531	0.7771
Loa Loa (eye worm)	glutamate receptor 1	0.0033	0.0148	0.0061
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0064	0.0531	0.7157
Onchocerca volvulus		0.0064	0.0531	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0064	0.0531	0.7771
Schistosoma mansoni	adenoreceptor	0.0064	0.0531	0.7157
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Leishmania major	hypothetical protein, conserved	0.0104	0.1017	0.0937
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0064	0.0531	0.7157
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0064	0.0531	0.7771
Brugia malayi	neuropeptide F receptor	0.0064	0.0531	0.0447
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0683	1
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Echinococcus granulosus	somatostatin receptor	0.0064	0.0531	0.7771
Schistosoma mansoni	neuropeptide F-like receptor	0.0064	0.0531	0.7157
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0064	0.0531	0.7157
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0064	0.0531	0.7157
Echinococcus granulosus	rhodopsin orphan GPCR	0.0064	0.0531	0.7771
Echinococcus multilocularis	dro:myosuppressin receptor	0.0064	0.0531	0.7771
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0423	0.6199
Brugia malayi	AKH receptor	0.0064	0.0531	0.0447
Schistosoma mansoni	hypothetical protein	0.0064	0.0531	0.7157
Echinococcus granulosus	neuropeptide receptor	0.0064	0.0531	0.7771
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0064	0.0531	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0064	0.0531	0.7771
Brugia malayi	hypothetical protein	0.0064	0.0531	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Brugia malayi	hypothetical protein	0.0064	0.0531	0.0447
Schistosoma mansoni	biogenic amine receptor	0.0064	0.0531	0.7157
Echinococcus granulosus	neuropeptide Y receptor	0.0064	0.0531	0.7771
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0064	0.0531	0.7157
Leishmania major	inosine-adenosine-guanosine-nucleoside hydrolase, putative	0.0504	0.5902	0.5866
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0064	0.0531	0.7157
Echinococcus multilocularis	neuropeptides capa receptor	0.0064	0.0531	0.7771
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0064	0.0531	0.7771
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0064	0.0531	0.7157
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0064	0.0531	0.7771
Echinococcus multilocularis	G protein coupled receptor 139	0.0064	0.0531	0.7771
Loa Loa (eye worm)	hypothetical protein	0.0429	0.4988	0.4944
Brugia malayi	hypothetical protein	0.0064	0.0531	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0028	0.0087	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0064	0.0531	0.7771
Onchocerca volvulus		0.0064	0.0531	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0064	0.0531	0.7771
Echinococcus granulosus	rhodopsin orphan GPCR	0.0064	0.0531	0.7771
Schistosoma mansoni	myosin xvIII	0.0064	0.0531	0.7157
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0033	0.0148	0.216
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Echinococcus multilocularis	neuropeptide Y receptor	0.0064	0.0531	0.7771
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0423	0.5151
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Loa Loa (eye worm)	TYRA-2 protein	0.0064	0.0531	0.0447
Onchocerca volvulus		0.0064	0.0531	0.5
Echinococcus multilocularis	glutamate receptor 2	0.0033	0.0148	0.216
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0033	0.0148	0.216
Echinococcus granulosus	rhodopsin orphan GPCR	0.0064	0.0531	0.7771
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0064	0.0531	0.7771
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Echinococcus granulosus	G protein coupled receptor 139	0.0064	0.0531	0.7771
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0064	0.0531	0.7771
Trypanosoma cruzi	inosine-guanine nucleoside hydrolase, putative	0.0133	0.1378	0.1302
Onchocerca volvulus		0.0064	0.0531	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0064	0.0531	0.7771
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0064	0.0531	0.7157
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0064	0.0531	0.7771
Brugia malayi	Glutamate receptor 2 precursor	0.0033	0.0148	0.0061
Onchocerca volvulus		0.0064	0.0531	0.5
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.084	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0104	0.1017	0.0937
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0033	0.0148	0.216
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0064	0.0531	0.0447
Echinococcus granulosus	rhodopsin orphan GPCR	0.0064	0.0531	0.7771
Brugia malayi	sulfakinin receptor protein	0.0064	0.0531	0.0447
Onchocerca volvulus		0.0064	0.0531	0.5
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0033	0.0148	0.216
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0064	0.0531	0.7157
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0064	0.0531	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0064	0.0531	0.7771
Brugia malayi	ORL1-like opioid receptor	0.0064	0.0531	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Trichomonas vaginalis	inosine-uridine preferring nucleoside hydrolase, putative	0.0133	0.1378	1
Trypanosoma cruzi	inosine-adenosine-guanosine-nucleosidehydrolase, putative	0.0504	0.5902	0.5866
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Echinococcus multilocularis	neuropeptide receptor A26	0.0064	0.0531	0.7771
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0064	0.0531	0.7771
Echinococcus granulosus	tm gpcr rhodopsin	0.0064	0.0531	0.7771
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0683	0.0601
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0064	0.0531	0.0447
Schistosoma mansoni	amine GPCR	0.0064	0.0531	0.7157
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0423	0.6199
Echinococcus multilocularis	glutamate receptor 2	0.0033	0.0148	0.216
Brugia malayi	Serotonin receptor	0.0064	0.0531	0.0447
Echinococcus multilocularis	g protein coupled receptor	0.0064	0.0531	0.7771
Echinococcus granulosus	g protein coupled receptor	0.0064	0.0531	0.7771
Brugia malayi	follicle stimulating hormone receptor	0.0064	0.0531	0.0447
Onchocerca volvulus		0.0064	0.0531	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0064	0.0531	0.7771
Loa Loa (eye worm)	G-protein coupled receptor	0.0064	0.0531	0.0447
Echinococcus granulosus	neuropeptide receptor A26	0.0064	0.0531	0.7771
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0033	0.0148	0.216
Echinococcus granulosus	g protein coupled receptor	0.0064	0.0531	0.7771
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Brugia malayi	hypothetical protein	0.0064	0.0531	0.0447
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0064	0.0531	0.7157
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0064	0.0531	0.7771
Brugia malayi	Dopamine receptor protein 1	0.0064	0.0531	0.0447
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0064	0.0531	0.7771
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Brugia malayi	G protein-coupled receptor	0.0064	0.0531	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Echinococcus multilocularis	fmrfamide receptor	0.0064	0.0531	0.7771
Echinococcus granulosus	neuropeptide receptor	0.0064	0.0531	0.7771
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0064	0.0531	0.7157
Trichomonas vaginalis	inosine-uridine preferring nucleoside hydrolase, putative	0.0133	0.1378	1
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0683	0.0601
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0683	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0064	0.0531	0.7157
Brugia malayi	hypothetical protein	0.0064	0.0531	0.0447
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0033	0.0148	0.216
Echinococcus granulosus	g-protein coupled receptor	0.0064	0.0531	0.7771
Echinococcus granulosus	rhodopsin orphan GPCR	0.0064	0.0531	0.7771
Loa Loa (eye worm)	glutamate receptor 2	0.0033	0.0148	0.0061
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0064	0.0531	0.7771
Echinococcus multilocularis	fmrfamide receptor	0.0064	0.0531	0.7771
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Echinococcus multilocularis	somatostatin receptor	0.0064	0.0531	0.7771
Brugia malayi	hypothetical protein	0.0064	0.0531	0.0447
Leishmania major	nonspecific nucleoside hydrolase	0.0133	0.1378	0.1302
Schistosoma mansoni	hypothetical protein	0.0064	0.0531	0.7157
Brugia malayi	G protein-coupled receptor F59B2.13	0.0064	0.0531	0.0447
Schistosoma mansoni	amine GPCR	0.0064	0.0531	0.7157
Schistosoma mansoni	hypothetical protein	0.0064	0.0531	0.7157
Echinococcus granulosus	biogenic amine 5HT receptor	0.0064	0.0531	0.7771
Schistosoma mansoni	neuropeptide receptor	0.0064	0.0531	0.7157
Brugia malayi	larval opioid receptor	0.0064	0.0531	0.0447
Mycobacterium tuberculosis	Probable nucleoside hydrolase IunH (purine nucleosidase)	0.0133	0.1378	0.5
Brugia malayi	RE15519p	0.0064	0.0531	0.0447
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0064	0.0531	0.0447
Leishmania major	C-8 sterol isomerase-like protein	0.084	1	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0683	0.0601
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0064	0.0531	0.0447
Schistosoma mansoni	opsin-like receptor	0.0064	0.0531	0.7157
Brugia malayi	Melatonin receptor type 1A	0.0064	0.0531	0.0447
Brugia malayi	neuropeptide F receptor	0.0064	0.0531	0.0447
Echinococcus granulosus	fmrfamide receptor	0.0064	0.0531	0.7771
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0064	0.0531	0.0447
Echinococcus granulosus	rhodopsin orphan GPCR	0.0064	0.0531	0.7771
Onchocerca volvulus		0.0064	0.0531	0.5
Brugia malayi	RNA binding protein	0.0076	0.0683	0.0601
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0064	0.0531	0.7157
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0064	0.0531	0.7771
Schistosoma mansoni	growth hormone secretagogue receptor	0.0064	0.0531	0.7157
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0064	0.0531	0.0447
Brugia malayi	G-protein coupled receptor	0.0064	0.0531	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Echinococcus granulosus	g protein coupled receptor	0.0064	0.0531	0.7771
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0447
Onchocerca volvulus		0.0064	0.0531	0.5
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0033	0.0148	0.216
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0423	0.6199
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0064	0.0531	0.7771
Brugia malayi	hypothetical protein	0.0064	0.0531	0.0447
Loa Loa (eye worm)	neuropeptide F receptor	0.0064	0.0531	0.0447
Loa Loa (eye worm)	G-protein coupled receptor	0.0064	0.0531	0.0447

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	141.2538 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2356423

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1757848