Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Lipase family protein | 0.2141 | 0.3589 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0381 | 0.0491 | 0.1254 |
Leishmania major | hypothetical protein, conserved | 0.0314 | 0.0373 | 0.0919 |
Trypanosoma cruzi | Alpha/beta hydrolase family, putative | 0.0314 | 0.0373 | 0.0919 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.2141 | 0.3589 | 1 |
Loa Loa (eye worm) | lipase | 0.2141 | 0.3589 | 1 |
Echinococcus granulosus | abhydrolase domain containing protein 11 | 0.0381 | 0.0491 | 0.1254 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.2141 | 0.3589 | 1 |
Plasmodium vivax | alpha/beta hydrolase, putative | 0.0381 | 0.0491 | 0.5 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.2141 | 0.3589 | 1 |
Toxoplasma gondii | hydrolase, alpha/beta fold family protein | 0.0314 | 0.0373 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.012 | 0.0031 | 0.0031 |
Wolbachia endosymbiont of Brugia malayi | esterase | 0.0129 | 0.0047 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase family, putative | 0.0314 | 0.0373 | 0.0919 |
Plasmodium falciparum | alpha/beta hydrolase, putative | 0.0381 | 0.0491 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0626 | 0.0923 | 0.0939 |
Echinococcus multilocularis | abhydrolase domain containing protein 11 | 0.0381 | 0.0491 | 0.1254 |
Trypanosoma brucei | Alpha/beta hydrolase family, putative | 0.0314 | 0.0373 | 0.0919 |
Mycobacterium tuberculosis | Probable haloalkane dehalogenase | 0.012 | 0.0031 | 0.0031 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0626 | 0.0923 | 0.0923 |
Trypanosoma brucei | lipase domain protein, putative | 0.2141 | 0.3589 | 1 |
Mycobacterium tuberculosis | Possible hydrolase | 0.0314 | 0.0373 | 0.0379 |
Trypanosoma brucei | lipase domain protein, putative | 0.2141 | 0.3589 | 1 |
Chlamydia trachomatis | lysophospholipase esterase | 0.0129 | 0.0047 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.012 | 0.0031 | 0.0031 |
Trichomonas vaginalis | lipase containing protein, putative | 0.2141 | 0.3589 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.2141 | 0.3589 | 0.5 |
Brugia malayi | hydrolase, alpha/beta fold family protein | 0.0314 | 0.0373 | 0.0919 |
Leishmania major | hypothetical protein, conserved | 0.2141 | 0.3589 | 1 |
Schistosoma mansoni | family S33 non-peptidase homologue (S33 family) | 0.0381 | 0.0491 | 1 |
Mycobacterium leprae | Possible short-chain dehydrogenase EphD | 0.0102 | 0 | 0.5 |
Mycobacterium tuberculosis | 4,9-DHSA hydrolase | 0.569 | 0.9836 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.2141 | 0.3589 | 1 |
Mycobacterium tuberculosis | Possible haloalkane dehalogenase | 0.012 | 0.0031 | 0.0031 |
Mycobacterium ulcerans | hydrolase | 0.0314 | 0.0373 | 0.0373 |
Onchocerca volvulus | 0.2141 | 0.3589 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.