Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0063 | 0.0305 | 1 |
Plasmodium vivax | hypothetical protein | 0.0041 | 0.0149 | 0.3164 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0287 | 0.0212 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.1482 | 0.1417 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0063 | 0.0305 | 0.0343 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0076 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0305 | 0.023 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0152 | 0.0157 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0063 | 0.0305 | 0.0347 |
Onchocerca volvulus | 0.0247 | 0.1607 | 0.1481 | |
Brugia malayi | Serotonin receptor | 0.0458 | 0.3106 | 0.3199 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.0041 | 0.0149 | 0.0153 |
Schistosoma mansoni | amine oxidase | 0.0063 | 0.0305 | 0.1172 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0149 | 0.0073 |
Schistosoma mansoni | zinc finger protein | 0.0041 | 0.0149 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0149 | 0.0073 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0229 | 0.1482 | 0.2959 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0287 | 0.0296 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.008 | 0.043 | 0.0443 |
Brugia malayi | SWIRM domain containing protein | 0.0247 | 0.1607 | 0.1655 |
Brugia malayi | hypothetical protein | 0.003 | 0.0076 | 0.0079 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0252 | 0.0229 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0063 | 0.0305 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0152 | 0.0076 |
Plasmodium vivax | hypothetical protein, conserved | 0.0063 | 0.0305 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0063 | 0.0305 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0063 | 0.0305 | 0.5 |
Echinococcus multilocularis | 0.0063 | 0.0305 | 0.0347 | |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0063 | 0.0305 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0252 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0149 | 0.0073 |
Onchocerca volvulus | CoRest homolog | 0.1432 | 1 | 1 |
Schistosoma mansoni | amine oxidase | 0.0063 | 0.0305 | 0.1172 |
Brugia malayi | ELM2 domain containing protein | 0.0041 | 0.0149 | 0.0153 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0252 | 0.0177 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0063 | 0.0305 | 1 |
Brugia malayi | hypothetical protein | 0.0063 | 0.0305 | 0.0314 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.043 | 0.0356 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0063 | 0.0305 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.1607 | 0.1543 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0252 | 0.0259 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0063 | 0.0305 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0331 | 0.2203 | 1 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0229 | 0.1482 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0252 | 0.0774 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0252 | 0.0774 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0252 | 0.0229 |
Plasmodium vivax | hypothetical protein, conserved | 0.0063 | 0.0305 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0152 | 0.0027 |
Echinococcus granulosus | hypothetical protein | 0.0684 | 0.4704 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0252 | 0.0227 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0331 | 0.2203 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1391 | 0.9712 | 0.971 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0063 | 0.0305 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0229 | 0.1482 | 0.2927 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0252 | 0.0774 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.1482 | 0.1417 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0268 | 0.1759 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0063 | 0.0305 | 0.1172 |
Loa Loa (eye worm) | GATA zinc finger family protein | 0.0041 | 0.0149 | 0.0073 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0063 | 0.0305 | 0.5 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0677 | 0.4655 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0287 | 0.0296 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0287 | 0.0212 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.1391 | 0.9712 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0063 | 0.0305 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0063 | 0.0305 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0305 | 0.023 |
Brugia malayi | ELM2 domain containing protein | 0.0041 | 0.0149 | 0.0153 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.