Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Cryptosporidium parvum | inosine-5-monophosphate dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | sodium:hydrogen exchanger | 0.008 | 0.0936 | 0.0936 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0098 | 0.2049 | 0.1229 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0228 | 1 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0098 | 0.2049 | 0.1229 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0124 | 0.3635 | 0.1633 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0223 | 0.9656 | 0.5 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0228 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.008 | 0.0936 | 0.0936 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.008 | 0.0936 | 0.0936 |
Loa Loa (eye worm) | GMP reductase | 0.0098 | 0.2049 | 0.1229 |
Trypanosoma cruzi | GMP reductase | 0.0228 | 1 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.008 | 0.0936 | 0.0936 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0223 | 0.9656 | 0.5 |
Giardia lamblia | Sodium/hydrogen exchanger 3 | 0.008 | 0.0936 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0228 | 1 | 1 |
Leishmania major | guanosine monophosphate reductase | 0.0228 | 1 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.008 | 0.0936 | 0.0936 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0228 | 1 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0228 | 1 | 0.5 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0228 | 1 | 0.5 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0228 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0228 | 1 | 0.5 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0228 | 1 | 1 |
Toxoplasma gondii | IMP dehydrogenas | 0.0228 | 1 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.008 | 0.0936 | 0.0936 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.008 | 0.0936 | 0.0936 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0228 | 1 | 1 |
Onchocerca volvulus | Putative GMP reductase | 0.0098 | 0.2049 | 1 |
Trypanosoma brucei | GMP reductase | 0.0228 | 1 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.008 | 0.0936 | 0.0936 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0228 | 1 | 0.5 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0228 | 1 | 1 |
Brugia malayi | GMP reductase | 0.0098 | 0.2049 | 0.1229 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0228 | 1 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.0228 | 1 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.008 | 0.0936 | 0.0936 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.008 | 0.0936 | 0.0936 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0223 | 0.9656 | 0.9548 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 240 nM | Inhibition of Cryptosporidium parvum N-terminal His6-tagged IMPDH-mediated NADH production expressed in Escherichia coli BL21(DE3) preincubated for 5 mins prior to substrate addition by fluorescence assay | ChEMBL. | 23668331 |
IC50 (binding) | = 600 nM | Inhibition of Cryptosporidium parvum N-terminal His6-tagged IMPDH-mediated NADH production expressed in Escherichia coli BL21(DE3) preincubated for 5 mins prior to substrate addition by fluorescence assay in presence of BSA | ChEMBL. | 23668331 |
IC50 (binding) | > 5 uM | Inhibition of human IMPDH2 | ChEMBL. | 23668331 |
Kis (binding) | = 150 nM | Competitive inhibition of Cryptosporidium parvum N-terminal His6-tagged IMPDH-mediated NADH production expressed in Escherichia coli BL21(DE3) using NAD as substrate by Lineweaver-Burk plot analysis | ChEMBL. | 23668331 |
Kis (binding) | = 210 nM | Noncompetitive inhibition of Cryptosporidium parvum N-terminal His6-tagged IMPDH-mediated NADH production expressed in Escherichia coli BL21(DE3) using IMP as substrate by Lineweaver-Burk plot analysis | ChEMBL. | 23668331 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.