Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 7 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 0.3569 | 0.3569 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0418 | 0.1879 | 0.1879 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0063 | 0 | 0.5 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.195 | 1 | 1 |
Schistosoma mansoni | CD36-like class B scavenger receptor | 0.195 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.195 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0418 | 0.1879 | 0.1879 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.195 | 1 | 1 |
Echinococcus multilocularis | lysosome membrane protein 2 | 0.195 | 1 | 1 |
Echinococcus granulosus | lysosome membrane protein 2 | 0.195 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0418 | 0.1879 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0063 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0063 | 0 | 0.5 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0418 | 0.1879 | 1 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.195 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0418 | 0.1879 | 0.1879 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0418 | 0.1879 | 0.1879 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0418 | 0.1879 | 0.1879 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.195 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0063 | 0 | 0.5 |
Schistosoma mansoni | CD36-like class B scavenger receptor | 0.195 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.195 | 1 | 1 |
Schistosoma mansoni | scavenger receptor class B type-2 (sr-B2) | 0.195 | 1 | 1 |
Onchocerca volvulus | Lysosome membrane protein 2 homolog | 0.195 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0736 | 0.3569 | 0.3569 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.195 | 1 | 1 |
Schistosoma mansoni | cd36 antigen | 0.0736 | 0.3569 | 0.3569 |
Brugia malayi | P38 map kinase family protein 2 | 0.0418 | 0.1879 | 0.1879 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0418 | 0.1879 | 0.1879 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0063 | 0 | 0.5 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.195 | 1 | 1 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.195 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0418 | 0.1879 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 0.3569 | 0.3569 |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 0.3569 | 0.3569 |
Brugia malayi | hypothetical protein | 0.0736 | 0.3569 | 0.3569 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.195 | 1 | 1 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.195 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0418 | 0.1879 | 0.1879 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.195 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.195 | 1 | 1 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0418 | 0.1879 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0063 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 810 nM | Inhibition of ERK5 phosphorylation in sorbitol-stimulated human HeLa cells | ChEMBL. | 23656407 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.