Detailed information for compound 1761952

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 393.432 | Formula: C23H23NO5
  • H donors: 0 H acceptors: 2 LogP: 3.21 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C1=NOC2(C1)C(=O)O[C@H]1[C@H]2CC[C@@]2(C1=C(C)C(=O)C=C2)C
  • InChi: 1S/C23H23NO5/c1-13-18(25)9-11-22(2)10-8-16-20(19(13)22)28-21(26)23(16)12-17(24-29-23)14-4-6-15(27-3)7-5-14/h4-7,9,11,16,20H,8,10,12H2,1-3H3/t16-,20+,22+,23?/m1/s1
  • InChiKey: OCFYALVTQHAIBC-VSWXYFIDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0185 0.0267 0.1249
Schistosoma mansoni nAChR subunit 0.03 0.0483 0.1417
Schistosoma mansoni hypothetical protein 0.0185 0.0267 0.0784
Echinococcus multilocularis sodium channel protein 0.0065 0.0041 0.0041
Echinococcus granulosus neuropeptide receptor 0.0337 0.0553 0.0553
Loa Loa (eye worm) hypothetical protein 0.0134 0.0171 0.0799
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0267 0.0267
Echinococcus granulosus glycine receptor subunit alpha 1 0.03 0.0483 0.0483
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0121 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Echinococcus multilocularis Mastin 0.0201 0.0298 0.0298
Schistosoma mansoni neuropeptide receptor 0.0185 0.0267 0.0784
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0053 0.0246
Brugia malayi G protein-coupled receptor F59B2.13 0.0185 0.0267 0.1249
Echinococcus granulosus dro:myosuppressin receptor 0.0185 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Loa Loa (eye worm) calcium channel 0.0121 0.0148 0.0691
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.03 0.0483 0.0483
Schistosoma mansoni hypothetical protein 0.0185 0.0267 0.0784
Echinococcus multilocularis serotonin receptor 0.0185 0.0267 0.0267
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0053 0.0154
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1252 0.2266 0.6646
Loa Loa (eye worm) hypothetical protein 0.03 0.0483 0.2257
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0302 0.0486 0.0486
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0267 0.0784
Schistosoma mansoni transient receptor potential channel 0.0093 0.0095 0.0278
Schistosoma mansoni integrin alpha-ps 0.0089 0.0086 0.0254
Plasmodium falciparum cysteine repeat modular protein 1 0.0295 0.0474 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0002 0.0008
Echinococcus granulosus enteropeptidase 0.0201 0.0298 0.0298
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0014 0.0067
Schistosoma mansoni neuropeptide F-like receptor 0.0185 0.0267 0.0784
Loa Loa (eye worm) GABA receptor subunit 0.0167 0.0233 0.1087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0267 0.0784
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0121 0.0148 0.0148
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0267 0.0267
Echinococcus multilocularis tyrosine protein kinase Abl 0.0068 0.0048 0.0048
Schistosoma mansoni amine GPCR 0.0185 0.0267 0.0784
Loa Loa (eye worm) hypothetical protein 0.013 0.0163 0.0763
Brugia malayi TAR-binding protein 0.0071 0.0053 0.0246
Echinococcus multilocularis neuropeptide receptor 0.0185 0.0267 0.0267
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.003 0.014
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.0267 0.0267
Onchocerca volvulus 0.0185 0.0267 0.049
Schistosoma mansoni nAChR subunit 0.03 0.0483 0.1417
Loa Loa (eye worm) hypothetical protein 0.0068 0.0048 0.0223
Brugia malayi Dopamine receptor protein 1 0.0185 0.0267 0.1249
Echinococcus multilocularis glycine receptor subunit alpha 1 0.03 0.0483 0.0483
Loa Loa (eye worm) hypothetical protein 0.03 0.0483 0.2257
Loa Loa (eye worm) hypothetical protein 0.0191 0.0278 0.13
Schistosoma mansoni hypothetical protein 0.0201 0.0298 0.0874
Toxoplasma gondii PAN domain-containing protein 0.0191 0.0278 0.0791
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0185 0.0267 0.0784
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0009 0.0026
Echinococcus granulosus tyrosine protein kinase Fyn 0.0302 0.0486 0.0486
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0512 0.088 0.411
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Schistosoma mansoni cercarial elastase (S01 family) 0.0201 0.0298 0.0874
Echinococcus granulosus tyrosine protein kinase Lyn 0.0302 0.0486 0.0486
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.03 0.0483 0.0483
Echinococcus multilocularis glycine receptor subunit alpha 1 0.03 0.0483 0.0483
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0009 0.0026
Echinococcus granulosus tissue type plasminogen activator 0.0295 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0053 0.0154
Loa Loa (eye worm) hypothetical protein 0.03 0.0483 0.2257
Loa Loa (eye worm) hypothetical protein 0.0134 0.0171 0.0799
Echinococcus multilocularis voltage dependent calcium channel 0.0121 0.0148 0.0148
Toxoplasma gondii microneme protein MIC17C 0.0191 0.0278 0.0791
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0302 0.0486 0.0486
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0009 0.0026
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0134 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.03 0.0483 0.2257
Loa Loa (eye worm) hypothetical protein 0.0191 0.0278 0.13
Schistosoma mansoni neuropeptide F-like receptor 0.0185 0.0267 0.0784
Echinococcus granulosus tar DNA binding protein 0.0071 0.0053 0.0053
Onchocerca volvulus 0.0191 0.0278 0.0545
Schistosoma mansoni tyrosine kinase 0.0068 0.0048 0.014
Schistosoma mansoni cercarial elastase (S01 family) 0.0201 0.0298 0.0874
Echinococcus granulosus serotonin receptor 0.0185 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0134 0.0171 0.0799
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0047 0.0009 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0267 0.0267
Echinococcus granulosus TRP transient receptor potential channel 0.0062 0.0036 0.0036
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0185 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.03 0.0483 0.2257
Echinococcus multilocularis short transient receptor potential channel 6 0.0093 0.0095 0.0095
Echinococcus granulosus short transient receptor potential channel 6 0.0093 0.0095 0.0095
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0267 0.0267
Echinococcus granulosus neuropeptide receptor A26 0.0185 0.0267 0.0267
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0272 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0047 0.0009 0.0042
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0185 0.0267 0.0267
Echinococcus multilocularis sex peptide receptor 0.0185 0.0267 0.0267
Echinococcus multilocularis glycine receptor subunit beta 0.03 0.0483 0.0483
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.0267 0.0267
Brugia malayi Integrin beta pat-3 precursor 0.0923 0.165 0.7705
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0264 0.0415 0.0415
Schistosoma mansoni neurotransmitter gated ion channel 0.0134 0.0171 0.0501
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.03 0.0483 0.0483
Brugia malayi hypothetical protein 0.0185 0.0267 0.1249
Brugia malayi Trypsin family protein 0.0201 0.0298 0.1391
Onchocerca volvulus Neuropeptide F receptor homolog 0.0185 0.0267 0.049
Echinococcus granulosus 7tm_1 domain containing protein 0.0185 0.0267 0.0267
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0065 0.0041 0.0041
Schistosoma mansoni neurotransmitter gated ion channel 0.0134 0.0171 0.0501
Schistosoma mansoni neurotransmitter gated ion channel 0.0167 0.0233 0.0683
Schistosoma mansoni cercarial elastase (S01 family) 0.0201 0.0298 0.0874
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0519 0.0893 0.2619
Loa Loa (eye worm) hypothetical protein 0.1185 0.2141 1
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0121 0.0148 0.0691
Echinococcus multilocularis serotonin receptor 0.0185 0.0267 0.0267
Loa Loa (eye worm) acetylcholine receptor protein 0.0134 0.0171 0.0799
Echinococcus granulosus neuropeptide FF receptor 2 0.0185 0.0267 0.0267
Echinococcus multilocularis transfer RNA-Gly 0.0047 0.0009 0.0009
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0233 0.0357 0.1046
Loa Loa (eye worm) hypothetical protein 0.03 0.0483 0.2257
Onchocerca volvulus 0.0185 0.0267 0.049
Loa Loa (eye worm) hypothetical protein 0.0295 0.0474 0.2214
Schistosoma mansoni nAChR subunit 0.03 0.0483 0.1417
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0047 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Schistosoma mansoni neuropeptide receptor 0.0185 0.0267 0.0784
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0201 0.0298 0.1391
Onchocerca volvulus 0.0519 0.0893 0.3665
Loa Loa (eye worm) hypothetical protein 0.0199 0.0293 0.1366
Echinococcus multilocularis integrin alpha ps 0.0089 0.0086 0.0086
Echinococcus granulosus neuropeptide s receptor 0.0185 0.0267 0.0267
Schistosoma mansoni nAChR subunit 0.03 0.0483 0.1417
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0267 0.0784
Brugia malayi hypothetical protein 0.0134 0.0171 0.0799
Onchocerca volvulus 0.0185 0.0267 0.049
Echinococcus multilocularis fmrfamide receptor 0.0185 0.0267 0.0267
Echinococcus granulosus neuropeptides capa receptor 0.0185 0.0267 0.0267
Loa Loa (eye worm) sex muscle abnormal protein 5 0.006 0.0032 0.0149
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0201 0.0298 0.0298
Brugia malayi excitatory GABA receptor EXP-1A 0.03 0.0483 0.2257
Brugia malayi G-protein coupled receptor 0.0185 0.0267 0.1249
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.03 0.0483 0.0483
Brugia malayi PAN domain containing protein 0.0191 0.0278 0.13
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0053 0.0246
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0185 0.0267 0.1249
Echinococcus multilocularis g protein coupled receptor 0.0185 0.0267 0.0267
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0167 0.0233 0.1087
Brugia malayi hypothetical protein 0.0134 0.0171 0.0799
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.03 0.0483 0.2257
Loa Loa (eye worm) hypothetical protein 0.0201 0.0298 0.1391
Schistosoma mansoni opsin-like receptor 0.0185 0.0267 0.0784
Brugia malayi Trypsin-like protease protein 5 0.0201 0.0298 0.1391
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.03 0.0483 0.2257
Echinococcus multilocularis shaker cognate 0.0047 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0201 0.0298 0.1391
Loa Loa (eye worm) hypothetical protein 0.0134 0.0171 0.0799
Loa Loa (eye worm) hypothetical protein 0.0134 0.0171 0.0799
Loa Loa (eye worm) hypothetical protein 0.0191 0.0278 0.13
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.03 0.0483 0.2257
Echinococcus granulosus voltage dependent calcium channel 0.0121 0.0148 0.0148
Entamoeba histolytica protein kinase, putative 0.0242 0.0374 1
Loa Loa (eye worm) hypothetical protein 0.03 0.0483 0.2257
Loa Loa (eye worm) SRC-1 0.0302 0.0486 0.2268
Echinococcus granulosus hypothetical protein 0.0185 0.0267 0.0267
Echinococcus multilocularis allatostatin A receptor 0.0185 0.0267 0.0267
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0134 0.0171 0.0171
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0185 0.0267 0.1249
Toxoplasma gondii PAN domain-containing protein 0.1909 0.3499 1
Schistosoma mansoni voltage-gated cation channel 0.0121 0.0148 0.0434
Brugia malayi PAN domain containing protein 0.0191 0.0278 0.13
Trypanosoma cruzi hypothetical protein, conserved 0.0295 0.0474 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0185 0.0267 0.0784
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0047 0.0009 0.0009
Echinococcus multilocularis neuropeptide receptor A26 0.0185 0.0267 0.0267
Brugia malayi PAN domain containing protein 0.0191 0.0278 0.13
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Loa Loa (eye worm) melatonin receptor type 1A 0.0185 0.0267 0.1249
Brugia malayi hypothetical protein 0.0185 0.0267 0.1249
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Onchocerca volvulus 0.0194 0.0284 0.0575
Echinococcus granulosus sex peptide receptor 0.0185 0.0267 0.0267
Echinococcus granulosus tyrosine protein kinase Src42A 0.0264 0.0415 0.0415
Echinococcus multilocularis neuropeptide s receptor 0.0185 0.0267 0.0267
Brugia malayi Dopamine receptor protein 2 0.0185 0.0267 0.1249
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.0267 0.0267
Schistosoma mansoni integrin alpha-4 0.0379 0.0631 0.1849
Echinococcus granulosus tyrosine kinase 0.0272 0.043 0.043
Brugia malayi SRC-1 0.0302 0.0486 0.2268
Onchocerca volvulus 0.0191 0.0278 0.0545
Echinococcus granulosus somatostatin receptor 0.0185 0.0267 0.0267
Schistosoma mansoni amine GPCR 0.0185 0.0267 0.0784
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0053 0.0246
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0302 0.0486 0.0486
Onchocerca volvulus 0.0191 0.0278 0.0545
Loa Loa (eye worm) PAN domain-containing protein 0.0191 0.0278 0.13
Loa Loa (eye worm) hypothetical protein 0.0134 0.0171 0.0799
Onchocerca volvulus 0.0185 0.0267 0.049
Toxoplasma gondii PAN domain-containing protein 0.1909 0.3499 1
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0134 0.0171 0.0799
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0185 0.0267 0.0784
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0185 0.0267 0.0267
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0267 0.0784
Echinococcus multilocularis transient receptor potential gamma protein 0.013 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0191 0.0278 0.13
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0302 0.0486 0.0486
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0068 0.0048 0.0048
Onchocerca volvulus 0.0191 0.0278 0.0545
Echinococcus multilocularis glycine receptor subunit alpha 1 0.03 0.0483 0.0483
Loa Loa (eye worm) hypothetical protein 0.0167 0.0233 0.1087
Toxoplasma gondii kringle domain-containing protein 0.0295 0.0474 0.1351
Onchocerca volvulus 0.0185 0.0267 0.049
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0272 0.043 0.043
Brugia malayi Cation transporter family protein 0.03 0.0483 0.2257
Loa Loa (eye worm) hypothetical protein 0.03 0.0483 0.2257
Toxoplasma gondii microneme protein MIC17B 0.0191 0.0278 0.0791
Loa Loa (eye worm) hypothetical protein 0.0201 0.0298 0.1391
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.03 0.0483 0.2257
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0302 0.0486 0.0486
Echinococcus granulosus glycine receptor subunit beta 0.03 0.0483 0.0483
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.03 0.0483 0.1417
Toxoplasma gondii subtilisin SUB12 0.0191 0.0278 0.0791
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.006 0.0032 0.0094
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0167 0.0233 0.1087
Onchocerca volvulus 0.0201 0.0298 0.0644
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.03 0.0483 0.2257
Schistosoma mansoni growth factor receptor-bound protein 0.006 0.0032 0.0094
Brugia malayi Muscle positioning protein 4 0.0199 0.0293 0.1366
Brugia malayi hypothetical protein 0.014 0.0183 0.0855
Onchocerca volvulus 0.0191 0.0278 0.0545
Loa Loa (eye worm) trypsin family protein 0.0201 0.0298 0.1391
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.03 0.0483 0.2257
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0185 0.0267 0.0267
Onchocerca volvulus 0.0519 0.0893 0.3665
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0083 0.0075 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.0007 0.0032
Echinococcus multilocularis potassium voltage gated channel protein 0.0047 0.0009 0.0009
Schistosoma mansoni biogenic amine receptor 0.0185 0.0267 0.0784
Toxoplasma gondii PAN domain-containing protein 0.0191 0.0278 0.0791
Schistosoma mansoni cercarial elastase (S01 family) 0.0201 0.0298 0.0874
Onchocerca volvulus 0.0185 0.0267 0.049
Loa Loa (eye worm) hypothetical protein 0.0134 0.0171 0.0799
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0302 0.0486 0.0486
Echinococcus granulosus fmrfamide receptor 0.0185 0.0267 0.0267
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.03 0.0483 0.0483
Schistosoma mansoni nAChR subunit 0.03 0.0483 0.1417
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0185 0.0267 0.0784
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0121 0.0148 0.0148
Loa Loa (eye worm) variant SH3 domain-containing protein 0.006 0.0032 0.0149
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0185 0.0267 0.1249
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0185 0.0267 0.0784
Loa Loa (eye worm) hypothetical protein 0.03 0.0483 0.2257
Loa Loa (eye worm) voltage-dependent calcium channel 0.0043 0.0002 0.0008
Loa Loa (eye worm) hypothetical protein 0.0134 0.0171 0.0799
Echinococcus multilocularis integrin alpha ps 0.0089 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0519 0.0893 0.417
Echinococcus granulosus alpha 1A adrenergic receptor 0.0185 0.0267 0.0267
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0134 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Echinococcus granulosus tyrosine protein kinase Fyn 0.0302 0.0486 0.0486
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.03 0.0483 0.0483
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.03 0.0483 0.2257
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0302 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0121 0.0148 0.0691
Schistosoma mansoni voltage-gated potassium channel 0.0512 0.088 0.2581
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0009 0.0026
Loa Loa (eye worm) PAN domain-containing protein 0.0191 0.0278 0.13
Onchocerca volvulus 0.0201 0.0298 0.0644
Schistosoma mansoni cercarial elastase (S01 family) 0.0201 0.0298 0.0874
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0172 0.0242 0.113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0267 0.0784
Onchocerca volvulus 0.0295 0.0474 0.1538
Echinococcus multilocularis g-protein coupled receptor 0.0185 0.0267 0.0267
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.03 0.0483 0.2257
Echinococcus multilocularis dro:myosuppressin receptor 0.0185 0.0267 0.0267
Brugia malayi ORL1-like opioid receptor 0.0185 0.0267 0.1249
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0134 0.0171 0.0799
Echinococcus multilocularis tyrosine protein kinase Blk 0.0272 0.043 0.043
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0512 0.088 0.088
Toxoplasma gondii hypothetical protein 0.0191 0.0278 0.0791
Schistosoma mansoni cercarial elastase (S01 family) 0.0201 0.0298 0.0874
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0267 0.0784
Echinococcus multilocularis orexin receptor type 2 0.0185 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0191 0.0278 0.13
Loa Loa (eye worm) hypothetical protein 0.0201 0.0298 0.1391
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0185 0.0267 0.0267
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0047 0.0009 0.0009
Schistosoma mansoni nck2/grb4 0.006 0.0032 0.0094
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0014 0.0067
Loa Loa (eye worm) DOMON domain-containing protein 0.0194 0.0284 0.1328
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0185 0.0267 0.0784
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0134 0.0171 0.0799
Loa Loa (eye worm) hypothetical protein 0.03 0.0483 0.2257
Echinococcus granulosus tm gpcr rhodopsin 0.0185 0.0267 0.0267
Echinococcus granulosus nAChR subunit 0.0167 0.0233 0.0233
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0267 0.0267
Brugia malayi PAN domain containing protein 0.0191 0.0278 0.13
Loa Loa (eye worm) LGC-31 protein 0.03 0.0483 0.2257
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.03 0.0483 0.0483
Echinococcus granulosus G protein coupled receptor 139 0.0185 0.0267 0.0267
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0201 0.0298 0.0874
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0014 0.0067
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.03 0.0483 0.2257
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0185 0.0267 0.0267
Echinococcus granulosus glycine receptor subunit alpha 1 0.03 0.0483 0.0483
Loa Loa (eye worm) hypothetical protein 0.0134 0.0171 0.0799
Brugia malayi hypothetical protein 0.0185 0.0267 0.1249
Brugia malayi Integrin alpha pat-2 precursor 0.0089 0.0086 0.0404
Onchocerca volvulus 0.1185 0.2141 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0047 0.0009 0.0009
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0185 0.0267 0.0784
Onchocerca volvulus 0.0201 0.0298 0.0644
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.049 0.0839 0.0839
Loa Loa (eye worm) hypothetical protein 0.0385 0.0642 0.3
Schistosoma mansoni cercarial elastase (S01 family) 0.0201 0.0298 0.0874
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.03 0.0483 0.2257
Schistosoma mansoni cercarial elastase (S01 family) 0.0201 0.0298 0.0874
Onchocerca volvulus Putative nachr subunit 0.03 0.0483 0.1585
Loa Loa (eye worm) hypothetical protein 0.0134 0.0171 0.0799
Onchocerca volvulus 0.0191 0.0278 0.0545
Loa Loa (eye worm) hypothetical protein 0.03 0.0483 0.2257
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.03 0.0483 0.1417
Onchocerca volvulus 0.0185 0.0267 0.049
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0185 0.0267 0.0267
Schistosoma mansoni transient receptor potential channel 0.0093 0.0095 0.0278
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0047 0.0009 0.0009
Onchocerca volvulus 0.03 0.0483 0.1585
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0185 0.0267 0.0267
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0201 0.0298 0.0298
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0185 0.0267 0.0267
Schistosoma mansoni histamine h1 receptor 0.0185 0.0267 0.0784
Brugia malayi putative neuropeptide receptor NPR1 0.0185 0.0267 0.1249
Echinococcus granulosus Mastin 0.0201 0.0298 0.0298
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0134 0.0171 0.0799
Brugia malayi Transient-receptor-potential like protein 0.0062 0.0036 0.0169
Brugia malayi Cation transporter family protein 0.0519 0.0893 0.417
Loa Loa (eye worm) neuropeptide F receptor 0.0185 0.0267 0.1249
Onchocerca volvulus 0.03 0.0483 0.1585
Loa Loa (eye worm) hypothetical protein 0.0047 0.0009 0.0042
Echinococcus granulosus 7TM GPCR rhodopsin 0.0185 0.0267 0.0267
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.03 0.0483 0.0483
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Schistosoma mansoni neuropeptide receptor 0.0185 0.0267 0.0784
Loa Loa (eye worm) hypothetical protein 0.0134 0.0171 0.0799
Onchocerca volvulus 0.0185 0.0267 0.049
Schistosoma mansoni nAChR subunit 0.0134 0.0171 0.0501
Loa Loa (eye worm) hypothetical protein 0.0134 0.0171 0.0799
Echinococcus multilocularis nAChR subunit 0.0167 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Echinococcus multilocularis transient receptor potential ion channel A 0.0104 0.0116 0.0116
Echinococcus multilocularis short transient receptor potential channel 6 0.0093 0.0095 0.0095
Brugia malayi PAN domain containing protein 0.0191 0.0278 0.13
Brugia malayi Kelch motif family protein 0.0172 0.0242 0.113
Echinococcus multilocularis voltage gated potassium channel 0.0047 0.0009 0.0009
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0009 0.0026
Echinococcus multilocularis tyrosine protein kinase Srms 0.0272 0.043 0.043
Brugia malayi Tyrosine-protein kinase abl-1 0.0068 0.0048 0.0224
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0185 0.0267 0.0784
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0167 0.0233 0.0683
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0167 0.0233 0.1087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0267 0.0784
Loa Loa (eye worm) hypothetical protein 0.0201 0.0298 0.1391
Brugia malayi hypothetical protein 0.0185 0.0267 0.1249
Loa Loa (eye worm) hypothetical protein 0.0191 0.0278 0.13
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.03 0.0483 0.0483
Echinococcus granulosus glycine receptor subunit beta 0.03 0.0483 0.0483
Onchocerca volvulus 0.0191 0.0278 0.0545
Echinococcus granulosus allatostatin A receptor 0.0185 0.0267 0.0267
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0134 0.0171 0.0799
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.03 0.0483 0.2257
Loa Loa (eye worm) hypothetical protein 0.0062 0.0036 0.0169
Echinococcus multilocularis G-protein coupled receptor, putative 0.0185 0.0267 0.0267
Echinococcus multilocularis fmrfamide receptor 0.0185 0.0267 0.0267
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.03 0.0483 0.0483
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0047 0.0009 0.0042
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0185 0.0267 0.0784
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.03 0.0483 0.1417
Brugia malayi Serotonin receptor 0.0185 0.0267 0.1249
Echinococcus granulosus biogenic amine 5HT receptor 0.0185 0.0267 0.0267
Echinococcus granulosus neuropeptide receptor 0.0185 0.0267 0.0267
Schistosoma mansoni integrin beta subunit 0.0543 0.0939 0.2753
Brugia malayi Cation transporter family protein 0.03 0.0483 0.2257
Echinococcus multilocularis voltage dependent calcium channel 0.0121 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Echinococcus granulosus potassium voltage gated channel protein 0.0047 0.0009 0.0009
Onchocerca volvulus 0.0194 0.0284 0.0575
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.0267 0.0267
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0295 0.0474 0.5
Onchocerca volvulus 0.03 0.0483 0.1585
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0009 0.0026
Echinococcus multilocularis g protein coupled receptor 0.0185 0.0267 0.0267
Schistosoma mansoni tyrosine kinase 0.0068 0.0048 0.014
Echinococcus granulosus tyrosine protein kinase Blk 0.0272 0.043 0.043
Echinococcus granulosus voltage gated potassium channel 0.0047 0.0009 0.0009
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.03 0.0483 0.2257
Loa Loa (eye worm) hypothetical protein 0.0067 0.0046 0.0213
Echinococcus granulosus potassium voltage gated channel protein 0.0512 0.088 0.088
Loa Loa (eye worm) hypothetical protein 0.03 0.0483 0.2257
Brugia malayi Protein kinase domain containing protein 0.0304 0.049 0.2288
Echinococcus multilocularis transmembrane protease serine 3 0.0201 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Leishmania major hypothetical protein, conserved 0.0295 0.0474 0.5
Onchocerca volvulus 0.0519 0.0893 0.3665
Echinococcus multilocularis enteropeptidase 0.0201 0.0298 0.0298
Brugia malayi putative neuropeptide receptor 0.0185 0.0267 0.1249
Loa Loa (eye worm) PAN domain-containing protein 0.0191 0.0278 0.13
Loa Loa (eye worm) hypothetical protein 0.0049 0.0011 0.0053
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0185 0.0267 0.0784
Echinococcus multilocularis nAChR subunit 0.03 0.0483 0.0483
Brugia malayi Sex muscle abnormal protein 5 0.006 0.0032 0.0149
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.03 0.0483 0.2257
Onchocerca volvulus 0.0185 0.0267 0.049
Echinococcus granulosus integrin beta 2 0.0683 0.1202 0.1202
Brugia malayi PAN domain containing protein 0.0191 0.0278 0.13
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0201 0.0298 0.0874
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Echinococcus granulosus tm gpcr rhodopsin 0.0185 0.0267 0.0267
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.03 0.0483 0.2257
Loa Loa (eye worm) TK/ROR protein kinase 0.0304 0.049 0.2288
Schistosoma mansoni hypothetical protein 0.0194 0.0284 0.0834
Echinococcus multilocularis tyrosine protein kinase HCK 0.0242 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.0167 0.0233 0.1087
Onchocerca volvulus 0.0167 0.0233 0.0314
Onchocerca volvulus 0.0194 0.0284 0.0575
Echinococcus granulosus nAChR subunit 0.03 0.0483 0.0483
Echinococcus multilocularis neuropeptide receptor 0.0337 0.0553 0.0553
Echinococcus multilocularis neuropeptides capa receptor 0.0185 0.0267 0.0267
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.03 0.0483 0.0483
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0185 0.0267 0.049
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0191 0.0278 0.0791
Onchocerca volvulus 0.0191 0.0278 0.0545
Onchocerca volvulus 0.0191 0.0278 0.0545
Schistosoma mansoni opsin-like receptor 0.0185 0.0267 0.0784
Echinococcus granulosus NCK adaptor protein 0.006 0.0032 0.0032
Brugia malayi protein-tyrosine kinase 0.0272 0.043 0.201
Schistosoma mansoni growth factor receptor-bound protein 0.006 0.0032 0.0094
Schistosoma mansoni cercarial elastase (S01 family) 0.0201 0.0298 0.0874
Loa Loa (eye worm) hypothetical protein 0.03 0.0483 0.2257
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0185 0.0267 0.0267
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0267 0.0267
Echinococcus granulosus orexin receptor type 2 0.0185 0.0267 0.0267
Brugia malayi hypothetical protein 0.0185 0.0267 0.1249
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0053 0.0154
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.03 0.0483 0.0483
Loa Loa (eye worm) hypothetical protein 0.0194 0.0284 0.1328
Schistosoma mansoni hypothetical protein 0.0185 0.0267 0.0784
Echinococcus granulosus tyrosine protein kinase Fyn 0.0302 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0167 0.0233 0.1087
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Schistosoma mansoni serine-type protease inhibitor 0.1862 0.341 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.0171 0.0799
Loa Loa (eye worm) hypothetical protein 0.03 0.0483 0.2257
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0134 0.0171 0.0171
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0302 0.0486 0.0486
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.03 0.0483 0.0483
Schistosoma mansoni cercarial elastase (S01 family) 0.0201 0.0298 0.0874
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Echinococcus multilocularis neuropeptides capa receptor 0.0185 0.0267 0.0267
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0185 0.0267 0.1249
Schistosoma mansoni neuropeptide receptor 0.0337 0.0553 0.1621
Onchocerca volvulus 0.0167 0.0233 0.0314
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0062 0.0036 0.0036
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0302 0.0486 0.0486
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0185 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0134 0.0171 0.0799
Loa Loa (eye worm) hypothetical protein 0.005 0.0014 0.0067
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0185 0.0267 0.1249
Echinococcus multilocularis growth factor receptor bound protein 2 0.006 0.0032 0.0032
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.03 0.0483 0.2257
Schistosoma mansoni tyrosine kinase 0.0302 0.0486 0.1424
Loa Loa (eye worm) hypothetical protein 0.03 0.0483 0.2257
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0094 0.0094
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.0267 0.0267
Onchocerca volvulus 0.0185 0.0267 0.049
Echinococcus multilocularis glycine receptor subunit beta 0.03 0.0483 0.0483
Brugia malayi hypothetical protein 0.0185 0.0267 0.1249
Brugia malayi PAN domain containing protein 0.0191 0.0278 0.13
Echinococcus multilocularis neuropeptide Y receptor 0.0185 0.0267 0.0267
Schistosoma mansoni biogenic amine (5HT) receptor 0.0185 0.0267 0.0784
Brugia malayi AKH receptor 0.0185 0.0267 0.1249
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0201 0.0298 0.0874
Onchocerca volvulus 0.0185 0.0267 0.049
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Schistosoma mansoni vesicular amine transporter 0.0047 0.0009 0.0026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0267 0.0267
Echinococcus multilocularis g protein coupled receptor 0.0185 0.0267 0.0267
Brugia malayi sulfakinin receptor protein 0.0185 0.0267 0.1249
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.0267 0.0267
Toxoplasma gondii microneme protein MIC17A 0.0191 0.0278 0.0791
Brugia malayi RE15519p 0.0185 0.0267 0.1249
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0185 0.0267 0.1249
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0185 0.0267 0.1249
Loa Loa (eye worm) integrin beta-2 0.0923 0.165 0.7705
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0185 0.0267 0.0267
Schistosoma mansoni hypothetical protein 0.0185 0.0267 0.0784
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0053 0.0154
Schistosoma mansoni voltage-gated potassium channel 0.0512 0.088 0.2581
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0185 0.0267 0.1249
Brugia malayi jmjC domain containing protein 0.0093 0.0094 0.044
Echinococcus multilocularis glycoprotein Antigen 5 0.0201 0.0298 0.0298
Schistosoma mansoni adapter molecule crk 0.006 0.0032 0.0094
Brugia malayi hypothetical protein 0.0134 0.0171 0.0799
Toxoplasma gondii microneme protein, putative 0.0191 0.0278 0.0791
Toxoplasma gondii PAN domain-containing protein 0.0191 0.0278 0.0791
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0185 0.0267 0.0267
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0201 0.0298 0.0298
Echinococcus granulosus transient receptor potential ion channel A 0.0104 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Echinococcus granulosus short transient receptor potential channel 6 0.0093 0.0095 0.0095
Echinococcus granulosus glycoprotein Antigen 5 0.0201 0.0298 0.0298
Onchocerca volvulus 0.0201 0.0298 0.0644
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0267 0.0267
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0121 0.0148 0.0148
Brugia malayi G protein-coupled receptor 0.0185 0.0267 0.1249
Schistosoma mansoni integrin alpha-ps 0.0046 0.0007 0.002
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0167 0.0233 0.1087
Schistosoma mansoni adenoreceptor 0.0185 0.0267 0.0784
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0053 0.0154
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Schistosoma mansoni biogenic amine receptor 0.0185 0.0267 0.0784
Loa Loa (eye worm) hypothetical protein 0.0046 0.0007 0.0032
Brugia malayi neuropeptide F receptor 0.0185 0.0267 0.1249
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1185 0.2141 0.6279
Loa Loa (eye worm) TK protein kinase 0.0272 0.043 0.201
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0167 0.0233 0.0683
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0185 0.0267 0.0784
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Onchocerca volvulus 0.0185 0.0267 0.049
Schistosoma mansoni tyrosine kinase 0.0302 0.0486 0.1424
Toxoplasma gondii PAN/Apple domain-containing protein 0.0191 0.0278 0.0791
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.03 0.0483 0.0483
Loa Loa (eye worm) voltage-gated potassium channel 0.0047 0.0009 0.0042
Schistosoma mansoni biogenic amine (5HT) receptor 0.0185 0.0267 0.0784
Brugia malayi neuropeptide F receptor 0.0185 0.0267 0.1249
Loa Loa (eye worm) hypothetical protein 0.0067 0.0046 0.0213
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.03 0.0483 0.2257
Onchocerca volvulus 0.0983 0.1764 0.8084
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.03 0.0483 0.2257
Brugia malayi hypothetical protein 0.0134 0.0171 0.0799
Loa Loa (eye worm) hypothetical protein 0.03 0.0483 0.2257
Echinococcus multilocularis somatostatin receptor 0.0185 0.0267 0.0267
Onchocerca volvulus 0.0185 0.0267 0.049
Echinococcus granulosus transient receptor potential gamma protein 0.013 0.0163 0.0163
Schistosoma mansoni biogenic amine receptor 0.0185 0.0267 0.0784
Echinococcus multilocularis NCK adaptor protein 0.006 0.0032 0.0032
Brugia malayi Dopamine receptor 0.0185 0.0267 0.1249
Loa Loa (eye worm) ACC-1 protein 0.03 0.0483 0.2257
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0185 0.0267 0.0267
Brugia malayi hypothetical protein 0.0201 0.0298 0.1391
Echinococcus granulosus integrin alpha ps 0.0089 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Schistosoma mansoni transient receptor potential channel 0.013 0.0163 0.0479
Brugia malayi Trypsin family protein 0.0201 0.0298 0.1391
Loa Loa (eye worm) hypothetical protein 0.0167 0.0233 0.1087
Brugia malayi PAN domain containing protein 0.0191 0.0278 0.13
Brugia malayi Kringle domain containing protein 0.0295 0.0474 0.2214
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0121 0.0148 0.0148
Brugia malayi follicle stimulating hormone receptor 0.0185 0.0267 0.1249
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0267 0.0784
Echinococcus multilocularis neuropeptide FF receptor 2 0.0185 0.0267 0.0267
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.03 0.0483 0.2257
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0185 0.0267 0.0784
Loa Loa (eye worm) hypothetical protein 0.1185 0.2141 1
Echinococcus granulosus growth factor receptor bound protein 2 0.006 0.0032 0.0032
Schistosoma mansoni amine GPCR 0.0185 0.0267 0.0784
Schistosoma mansoni transient receptor potential channel 4 0.013 0.0163 0.0479
Schistosoma mansoni myosin xvIII 0.0185 0.0267 0.0784
Onchocerca volvulus 0.0191 0.0278 0.0545
Brugia malayi Serotonin receptor 0.0185 0.0267 0.1249
Brugia malayi Tachykinin-like peptides receptor 99D 0.0185 0.0267 0.1249
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0059 0.0172
Loa Loa (eye worm) TYRA-2 protein 0.0185 0.0267 0.1249
Brugia malayi G-protein coupled receptor 0.0185 0.0267 0.1249
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0068 0.0048 0.0048
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0121 0.0148 0.0148
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.03 0.0483 0.2257
Echinococcus granulosus neuropeptide Y receptor 0.0185 0.0267 0.0267
Schistosoma mansoni amine GPCR 0.0185 0.0267 0.0784
Loa Loa (eye worm) hypothetical protein 0.0519 0.0893 0.417
Loa Loa (eye worm) ACC-1 protein 0.03 0.0483 0.2257
Loa Loa (eye worm) PAN domain-containing protein 0.0191 0.0278 0.13
Loa Loa (eye worm) TK protein kinase 0.0242 0.0374 0.1746
Loa Loa (eye worm) hypothetical protein 0.0167 0.0233 0.1087
Echinococcus granulosus g protein coupled receptor 0.0185 0.0267 0.0267
Schistosoma mansoni serine-type protease inhibitor 0.1862 0.341 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0302 0.0486 0.0486
Echinococcus granulosus biogenic amine 5HT receptor 0.0185 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.03 0.0483 0.2257
Echinococcus granulosus transmembrane protease serine 3 0.0201 0.0298 0.0298
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0201 0.0298 0.0298
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0519 0.0893 0.2619
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0134 0.0171 0.0799
Schistosoma mansoni acetylcholine receptor-related 0.0134 0.0171 0.0501
Loa Loa (eye worm) hypothetical protein 0.0167 0.0233 0.1087
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.03 0.0483 0.2257
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0201 0.0298 0.0874
Schistosoma mansoni opsin-like receptor 0.0185 0.0267 0.0784
Echinococcus granulosus peptide allatostatin:somatostatin 0.0185 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Toxoplasma gondii PAN domain-containing protein 0.0191 0.0278 0.0791
Onchocerca volvulus 0.0185 0.0267 0.049
Loa Loa (eye worm) hypothetical protein 0.03 0.0483 0.2257
Loa Loa (eye worm) integrin alpha pat-2 0.0089 0.0086 0.0404
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Echinococcus multilocularis c src tyrosine kinase 0.0068 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Schistosoma mansoni amine GPCR 0.0185 0.0267 0.0784
Schistosoma mansoni cercarial elastase (S01 family) 0.0201 0.0298 0.0874
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.5377 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0185 0.0267 0.1249
Echinococcus granulosus neuropeptides capa receptor 0.0185 0.0267 0.0267
Brugia malayi Variant SH3 domain containing protein 0.006 0.0032 0.0149
Toxoplasma gondii hypothetical protein 0.0191 0.0278 0.0791
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0068 0.0048 0.014
Loa Loa (eye worm) hypothetical protein 0.006 0.0032 0.0149
Echinococcus multilocularis G protein coupled receptor 139 0.0337 0.0553 0.0553
Brugia malayi Melatonin receptor type 1A 0.0185 0.0267 0.1249
Schistosoma mansoni acetylcholine receptor subunit beta 0.0134 0.0171 0.0501
Echinococcus multilocularis integrin beta 2 0.0683 0.1202 0.1202
Echinococcus granulosus neuropeptide Y receptor 0.0185 0.0267 0.0267
Echinococcus granulosus g-protein coupled receptor 0.0185 0.0267 0.0267
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0185 0.0267 0.1249
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0295 0.0474 0.139
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0134 0.0171 0.0799
Loa Loa (eye worm) PAN domain-containing protein 0.0191 0.0278 0.13
Brugia malayi PAN domain containing protein 0.0191 0.0278 0.13
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0185 0.0267 0.0784
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0185 0.0267 0.0267
Toxoplasma gondii microneme protein MIC4 0.0191 0.0278 0.0791
Echinococcus granulosus tachykinin peptides receptor 99D 0.0185 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0512 0.088 0.411
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Mycobacterium ulcerans hypothetical protein 0.0201 0.0298 0.5
Echinococcus granulosus g protein coupled receptor 0.0185 0.0267 0.0267
Onchocerca volvulus 0.0185 0.0267 0.049
Brugia malayi GnHR receptor homolog 0.0185 0.0267 0.1249
Loa Loa (eye worm) hypothetical protein 0.0167 0.0233 0.1087
Echinococcus granulosus glycine receptor subunit alpha 1 0.03 0.0483 0.0483
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0267 0.0784
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.03 0.0483 0.1417
Echinococcus multilocularis potassium voltage gated channel protein 0.0047 0.0009 0.0009
Brugia malayi RNA binding protein 0.0071 0.0053 0.0246
Loa Loa (eye worm) hypothetical protein 0.0191 0.0278 0.13
Echinococcus granulosus shaker cognate 0.0047 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Brugia malayi CUB domain containing protein 0.0067 0.0046 0.0213
Brugia malayi Trypsin family protein 0.1185 0.2141 1
Loa Loa (eye worm) RNA binding protein 0.0071 0.0053 0.0246
Brugia malayi larval opioid receptor 0.0185 0.0267 0.1249
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0201 0.0298 0.0874
Brugia malayi Variant SH3 domain containing protein 0.006 0.0032 0.0149
Echinococcus granulosus tyrosine protein kinase HCK 0.0242 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.014 0.0183 0.0855
Echinococcus granulosus g protein coupled receptor 0.0185 0.0267 0.0267
Onchocerca volvulus 0.0185 0.0267 0.049
Loa Loa (eye worm) G-protein coupled receptor 0.0185 0.0267 0.1249
Onchocerca volvulus 0.0199 0.0293 0.0617
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Echinococcus multilocularis neuropeptide Y receptor 0.0185 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0167 0.0233 0.1087
Brugia malayi hypothetical protein 0.0185 0.0267 0.1249
Onchocerca volvulus 0.0201 0.0298 0.0644
Brugia malayi hypothetical protein 0.0185 0.0267 0.1249
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0121 0.0148 0.0434
Schistosoma mansoni nAChR subunit 0.03 0.0483 0.1417
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0185 0.0267 0.0267
Echinococcus granulosus c src tyrosine kinase 0.0068 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0185 0.0267 0.0267
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0185 0.0267 0.0267
Brugia malayi hypothetical protein 0.0185 0.0267 0.1249
Echinococcus multilocularis potassium voltage gated channel protein 0.0512 0.088 0.088
Schistosoma mansoni nAChR subunit 0.03 0.0483 0.1417
Schistosoma mansoni nAChR subunit 0.0134 0.0171 0.0501
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0185 0.0267 0.0267
Brugia malayi hypothetical protein 0.0134 0.0171 0.0799
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0302 0.0486 0.0486
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.03 0.0483 0.0483
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0302 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Echinococcus granulosus tyrosine protein kinase Src64B 0.0302 0.0486 0.0486
Brugia malayi Trypsin family protein 0.0201 0.0298 0.1391
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0047 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0201 0.0298 0.0874
Onchocerca volvulus 0.0194 0.0284 0.0575
Loa Loa (eye worm) hypothetical protein 0.0185 0.0267 0.1249
Schistosoma mansoni neuropeptide f receptor 76f 0.0185 0.0267 0.0784
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.03 0.0483 0.2257
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0094 0.0094
Schistosoma mansoni integrin alpha 0.0089 0.0086 0.0254
Echinococcus multilocularis tissue type plasminogen activator 0.0295 0.0474 0.0474
Echinococcus granulosus voltage dependent calcium channel 0.0043 0.0002 0.0002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0185 0.0267 0.0784
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0121 0.0148 0.0148
Echinococcus granulosus potassium voltage gated channel protein 0.0047 0.0009 0.0009
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0134 0.0171 0.0799
Brugia malayi PAN domain containing protein 0.0191 0.0278 0.13
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0134 0.0171 0.0171
Onchocerca volvulus 0.0191 0.0278 0.0545
Schistosoma mansoni growth hormone secretagogue receptor 0.0185 0.0267 0.0784
Brugia malayi SEA domain containing protein 0.0194 0.0284 0.1328
Loa Loa (eye worm) hypothetical protein 0.0134 0.0171 0.0799
Loa Loa (eye worm) neuropeptide F receptor 0.0185 0.0267 0.1249
Onchocerca volvulus 0.0185 0.0267 0.049
Brugia malayi hypothetical protein 0.0185 0.0267 0.1249
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0121 0.0148 0.0434

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.2 uM Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay ChEMBL. 23501113
IC50 (functional) = 100 uM Antiproliferative activity against human Hep2 cells after 48 hrs by sulforhodamine B assay ChEMBL. 23501113

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 23501113

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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