Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | trypanothione reductase, putative | 492 aa | 548 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable ionic transporter integral membrane protein ChaA | 0.0273 | 0.0183 | 0.5 |
Entamoeba histolytica | sodium/calcium exchanger protein, putative | 0.0273 | 0.0183 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0183 | 0.0183 |
Echinococcus multilocularis | sodium calcium exchanger | 1.0825 | 1 | 1 |
Toxoplasma gondii | manganese resistance 1 protein, putative | 0.0273 | 0.0183 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.1909 | 0.1706 | 1 |
Schistosoma mansoni | sodium/calcium exchanger | 1.0825 | 1 | 1 |
Brugia malayi | K+-dependent Na+/Ca+ exchanger related-protein | 0.0273 | 0.0183 | 0.0463 |
Loa Loa (eye worm) | Na/Ca eXchangers family member | 0.0273 | 0.0183 | 0.0183 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0183 | 0.0183 |
Brugia malayi | Sodium/calcium exchanger protein | 0.433 | 0.3958 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.1909 | 0.1706 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0076 | 0 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0076 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0183 | 0.0183 |
Brugia malayi | Na/Ca eXchangers family member (ncx-4) | 0.0273 | 0.0183 | 0.0463 |
Loa Loa (eye worm) | solute carrier family 8 | 1.0825 | 1 | 1 |
Echinococcus granulosus | sodium:potassium:calcium exchanger 6 | 0.0273 | 0.0183 | 0.0183 |
Treponema pallidum | hypothetical protein | 0.0273 | 0.0183 | 0.5 |
Plasmodium falciparum | cation/H+ antiporter | 0.0273 | 0.0183 | 1 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0273 | 0.0183 | 0.0183 |
Schistosoma mansoni | na/ca exchanger | 0.0273 | 0.0183 | 0.0183 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger | 0.0273 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.433 | 0.3958 | 0.3958 |
Echinococcus granulosus | sodium:potassium:calcium exchanger | 0.0273 | 0.0183 | 0.0183 |
Plasmodium vivax | cation/H+ antiporter, putative | 0.0273 | 0.0183 | 1 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger 6 | 0.0273 | 0.0183 | 0.0183 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0273 | 0.0183 | 0.0183 |
Mycobacterium tuberculosis | Probable ionic transporter integral membrane protein ChaA | 0.0273 | 0.0183 | 1 |
Leishmania major | trypanothione reductase | 0.0076 | 0 | 0.5 |
Onchocerca volvulus | Sodium\/potassium\/calcium exchanger | 0.0273 | 0.0183 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.159 ug ml-1 | Antiparasitic activity against T. brucei | ChEMBL. | 10956223 |
ED50 (functional) | = 0.159 ug ml-1 | Antiparasitic activity against T. brucei | ChEMBL. | 10956223 |
ED50 (functional) | = 0.32 uM | Antiparasitic activity against T. brucei | ChEMBL. | 10956223 |
ED50 (functional) | = 0.32 uM | Antiparasitic activity against T. brucei | ChEMBL. | 10956223 |
IC50 (binding) | = 10.5 uM | Inhibitory activity against T. cruzi trypanothione reductase | ChEMBL. | 10956223 |
IC50 (binding) | = 10.5 uM | Inhibitory activity against T. cruzi trypanothione reductase | ChEMBL. | 10956223 |
Ki (binding) | = 2 mM | Inhibitory activity against Human Erythrocyte glutathione reductase (GR). | ChEMBL. | 10956223 |
Ki (binding) | = 2 mM | Inhibitory activity against Human Erythrocyte glutathione reductase (GR). | ChEMBL. | 10956223 |
Ki (binding) | = 2.3 uM | Inhibitory activity against T. cruzi trypanothione reductase | ChEMBL. | 10956223 |
Ki (binding) | = 2.3 uM | Inhibitory activity against T. cruzi trypanothione reductase | ChEMBL. | 10956223 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.