Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | catenin (cadherin-associated protein), beta 1, 88kDa | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.0288 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0288 | 0.5 |
Echinococcus multilocularis | beta catenin | 0.0116 | 0.3873 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.0288 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0288 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0288 | 0.0249 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0187 | 0.6701 | 0.1027 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.004 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0288 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.0288 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0271 | 1 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.0288 | 1 |
Brugia malayi | Armadillo/beta-catenin-like repeat family protein | 0.0116 | 0.3873 | 0.3691 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.004 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0796 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0796 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.004 | 0.139 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.0288 | 1 |
Onchocerca volvulus | Cirhin homolog | 0.0115 | 0.3842 | 0.589 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0796 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0271 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0187 | 0.6701 | 0.1027 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0271 | 1 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0271 | 1 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.0288 | 0.5 |
Echinococcus granulosus | beta catenin | 0.0116 | 0.3873 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.004 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0288 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0288 | 0.5 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0796 | 0.0523 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0178 | 0.6323 | 1 |
Loa Loa (eye worm) | HMP-2 protein | 0.0116 | 0.3873 | 0.3848 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0288 | 0.0249 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.0288 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0288 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.0288 | 1 |
Schistosoma mansoni | beta-catenin | 0.0116 | 0.3873 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0271 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0288 | 0.0249 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0271 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0288 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0271 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0796 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5 uM | Inhibition of beta-catenin-mediated transcriptional activity in Wnt3a-stimulated human HeLa cells after 24 hrs by Dual-Glo luciferase reporter gene assay | ChEMBL. | 23566764 |
Kd (binding) | = 13 nM | Binding affinity to human beta-catenin expressed in Escherichia coli BL21 after 45 mins by fluorescence polarization assay | ChEMBL. | 23566764 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.