Detailed view for Bm1_41790

Basic information

TDR Targets ID: 241854
Brugia malayi, Armadillo/beta-catenin-like repeat family protein
Source Database / ID:  GenBank

pI: 6.0658 | Length (AA): 1350 | MW (Da): 149163 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00514   Armadillo/beta-catenin-like repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0005488   binding  
GO:0045296   cadherin binding  
GO:0007155   cell adhesion  

Metabolic Pathways

Wnt signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 678 2bpt (A) 101 771 12.00 0 1 0.593933 0.24
31 168 4d49 (A) 14 163 17.00 0.00000028 1 0.424022 -1.55
34 92 4ons (B) 83 143 54.00 0.000021 0.37 0.505204 0.19
68 98 1dow (B) 119 149 58.00 0.0083 0.13 0.501763 0.91
68 739 1u6g (C) 51 838 14.00 0 1 0.531378 0.52
78 621 4r0z (A) 56 611 49.00 0 1 1.09656 -1.4
93 176 3nmw (A) 653 736 13.00 0.75 0.95 0.443022 -1.79
101 338 4rzp (A) 3 240 19.00 0 1 0.608896 -1.74
669 964 2qc5 (A) 0 294 9.00 0 0.2 0.264859 0.26
907 1143 5hqg (A) 484 730 25.00 0.0013 1 0.337056 0.72
1219 1293 2dpf (A) 21 99 33.00 0.52 0.36 0.231056 0.84
1251 1320 3dm0 (A) 1060 1133 17.00 0.66 0.16 0.134652 0.3

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130404)

Species Accession Gene Product
Brugia malayi Bm1_41790   Armadillo/beta-catenin-like repeat family protein
Caenorhabditis elegans CELE_K05C4.6   Protein HMP-2, isoform A
Drosophila melanogaster Dmel_CG11579   armadillo
Echinococcus granulosus EgrG_001007700   beta catenin
Echinococcus multilocularis EmuJ_001007700   beta catenin
Homo sapiens ENSG00000168036   catenin (cadherin-associated protein), beta 1, 88kDa
Homo sapiens ENSG00000173801   junction plakoglobin
Loa Loa (eye worm) LOAG_02412   HMP-2 protein
Mus musculus ENSMUSG00000006932   catenin (cadherin associated protein), beta 1
Mus musculus ENSMUSG00000001552   junction plakoglobin
Onchocerca volvulus OVOC1569   Cirhin homolog
Schistosoma japonicum Sjp_0130300   expressed protein
Schistosoma japonicum Sjp_0007530   ko:K02105 catenin (cadherin-associated protein), beta 1, putative
Schistosoma japonicum Sjp_0314030   Catenin beta-1, putative
Schistosoma mansoni Smp_023550   beta-catenin
Schmidtea mediterranea mk4.004027.01   Beta-catenin-1
Schmidtea mediterranea mk4.000209.06   Armadillo segment polarity protein

Essentiality

Bm1_41790 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_K05C4.6 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0214 0.2836 1
0.0202 0.2587 1
0.0415156 0.600438 1
0.0095 0.292 1
0.0116 0.3873 0.3691
0.0223 0.2532 1
0.0195 0.5832 1
0.0223 0.2532 1
0.0196 0.2963 1
0.0196 0.2963 1
0.0217 0.3186 1
0.0212 0.3001 1
0.0141 0.4058 0.9454
0.0093 0.3653 0.3653
0.0077 0.6166 0.7759
0.0116 0.2511 0.2823
0.0196 0.2963 1
0.0214 0.2552 1
0.0214 0.2836 1
0.0099 0.2606 0.7242
0.0108 0.38 1
0.0196 0.2963 1
0.0288 0.2655 0.3906
0.0116 0.7295 0.7295
0.0097 0.328 0.3407
0.0077 0.6196 0.7759
0.0214 0.3142 1
0.0146 0.6166 0.7759
0.0313 0.3711 0.7026
0.0116 0.3113 0.3917

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_41790 (Brugia malayi), Armadillo/beta-catenin-like repeat family protein
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