Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Reverse transcriptase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | 0.0092 | 0 | 0.5 |
Trichomonas vaginalis | retinoblastoma binding protein, putative | 0.0159 | 0.0641 | 0.0641 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.0641 | 0.0641 |
Echinococcus multilocularis | wd40 repeat | 0.0159 | 0.0641 | 0.0641 |
Echinococcus granulosus | wd40 repeat | 0.0159 | 0.0641 | 0.0641 |
Schistosoma mansoni | hypothetical protein | 0.1135 | 1 | 1 |
Trichomonas vaginalis | WD repeat domain, putative | 0.1135 | 1 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0167 | 0.0715 | 0.5 |
Echinococcus multilocularis | protein will die slowly | 0.1135 | 1 | 1 |
Loa Loa (eye worm) | WD40 repeat protein | 0.1135 | 1 | 1 |
Schistosoma mansoni | retinoblastoma binding protein | 0.0159 | 0.0641 | 0.0641 |
Onchocerca volvulus | 0.1135 | 1 | 0.5 | |
Brugia malayi | Hypothetical WD-repeat protein F21H12.1 in chromosome II | 0.0159 | 0.0641 | 0.0641 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0159 | 0.0641 | 0.0641 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0715 | 0.0715 |
Plasmodium falciparum | SPRY domain, putative | 0.0092 | 0 | 0.5 |
Echinococcus granulosus | protein will die slowly | 0.1135 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 25.4 uM | Cytotoxicity against human CEM-SS cells by XTT assay | ChEMBL. | 23631411 |
IC50 (binding) | = 0.42 uM | Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labeled DNA hybrid as substrate after 10 mins by fluorescence spectrometric analysis | ChEMBL. | 23631411 |
Inhibition (binding) | Inhibition of HIV-1 integrase using DNA duplex as substrate at 50 uM preincubated for 10 mins prior to substrate addition measured after 1 hr | ChEMBL. | 23631411 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.