Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxysteroid (11-beta) dehydrogenase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable oxidoreductase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Mycobacterium ulcerans | short chain dehydrogenase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxysteroid (11-beta) dehydrogenase 1 | 292 aa | 250 aa | 24.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | 6-phosphofructokinase | 0.0301 | 0.888 | 1 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0018 | 0.0273 | 0.0308 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0296 | 0.8726 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.0178 | 0.5128 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0415 | 0.0467 |
Echinococcus multilocularis | neuroglian | 0.0018 | 0.0279 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0138 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.888 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0338 | 1 | 1 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0014 | 0.0138 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0138 | 0.0156 |
Echinococcus granulosus | twitchin | 0.0018 | 0.0279 | 0.0315 |
Onchocerca volvulus | 0.0301 | 0.888 | 1 | |
Brugia malayi | hypothetical protein | 0.0014 | 0.0138 | 0.3827 |
Echinococcus granulosus | defective proboscis extension response | 0.0014 | 0.0138 | 0.0156 |
Schistosoma mansoni | cell adhesion molecule | 0.0018 | 0.0273 | 0.0308 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0296 | 0.8726 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0138 | 0.0156 |
Echinococcus multilocularis | Immunoglobulin | 0.0014 | 0.0138 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0138 | 0.0156 |
Schistosoma mansoni | tyrosine kinase | 0.0012 | 0.0088 | 0.0099 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0014 | 0.0138 | 0.0156 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0301 | 0.888 | 1 |
Echinococcus granulosus | Immunoglobulin | 0.0014 | 0.0138 | 0.0156 |
Giardia lamblia | Hypothetical protein | 0.0178 | 0.5128 | 0.5 |
Echinococcus granulosus | neuroglian | 0.0018 | 0.0279 | 0.0315 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0014 | 0.0138 | 0.3827 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0301 | 0.888 | 1 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0014 | 0.0138 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.4973 | 0.56 |
Loa Loa (eye worm) | hypothetical protein | 0.0296 | 0.8726 | 0.9826 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0296 | 0.8726 | 0.9706 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0301 | 0.888 | 1 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.0301 | 0.888 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0415 | 0.0467 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0021 | 0.0361 | 1 |
Schistosoma mansoni | nephrin | 0.0018 | 0.0279 | 0.0315 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0296 | 0.8726 | 0.9706 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0301 | 0.888 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.0014 | 0.0138 | 0.0156 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0301 | 0.888 | 1 |
Schistosoma mansoni | vesicular amine transporter | 0.0014 | 0.0138 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0273 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0138 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0138 | 0.0156 |
Echinococcus granulosus | roundabout 2 | 0.0023 | 0.0415 | 0.0467 |
Echinococcus multilocularis | roundabout 2 | 0.0023 | 0.0415 | 0.0467 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0178 | 0.5128 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0014 | 0.0138 | 0.3827 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0021 | 0.0361 | 0.0407 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 194 nM | Inhibition of 11beta-HSD1 in human HEK293 cells | ChEMBL. | 23489629 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.