TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 323.349 | Formula: C17H17N5O2
H donors: 0 H acceptors: 4 LogP: 3.57 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)Oc1ccc(cc1)c1nnn(n1)C(=O)N(C)C
InChi: 1S/C17H17N5O2/c1-12-4-8-14(9-5-12)24-15-10-6-13(7-11-15)16-18-20-22(19-16)17(23)21(2)3/h4-11H,1-3H3
InChiKey: GIHRXZIOYXHBBA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Anandamide amidohydrolase	Starlite/ChEMBL	References
Homo sapiens	monoglyceride lipase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	similar to YJU3	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei gambiense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium ulcerans	lysophospholipase	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania mexicana	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania donovani	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Leishmania major	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania infantum	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Echinococcus multilocularis	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Echinococcus granulosus	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	similar to YJU3	Get druggable targets OG5_127037	All targets in OG5_127037
Echinococcus granulosus	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Echinococcus multilocularis	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma japonicum	ko:K01175 fatty acid amide hydrolase [EC:3.1.-.-], putative	Get druggable targets OG5_127783	All targets in OG5_127783
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Plasmodium vivax	PST-A protein	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma cruzi	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania braziliensis	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	esterase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma mansoni	fatty-acid amide hydrolase	Get druggable targets OG5_127783	All targets in OG5_127783
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Get druggable targets OG5_127783	All targets in OG5_127783
Trypanosoma brucei gambiense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Schistosoma mansoni	amidase	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Mycobacterium tuberculosis	Possible lysophospholipase	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	valacyclovir hydrolase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Brugia malayi	amidase	Get druggable targets OG5_127783	All targets in OG5_127783

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	esterase, putative	monoglyceride lipase	303 aa	254 aa	19.7 %
Echinococcus granulosus	fatty acid amide hydrolase 1	Anandamide amidohydrolase	579 aa	470 aa	28.7 %
Echinococcus multilocularis	fatty acid amide hydrolase 1	Anandamide amidohydrolase	579 aa	470 aa	28.3 %
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Anandamide amidohydrolase	579 aa	499 aa	24.6 %
Onchocerca volvulus		Anandamide amidohydrolase	579 aa	539 aa	34.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	SHC transforming protein 3	0.036	0.497	0.497
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Trypanosoma brucei	Flagellum attachment zone protein 20	0.024	0.2453	0.5
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Echinococcus granulosus	expressed conserved protein	0.036	0.497	0.497
Echinococcus granulosus	tyrosine protein kinase	0.024	0.2453	0.2453
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.036	0.497	0.497
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.024	0.2453	0.2453
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0601	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0601	1	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.024	0.2453	0.5
Echinococcus multilocularis	tensin	0.036	0.497	0.497
Loa Loa (eye worm)	TK/FER protein kinase	0.024	0.2453	0.2453
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.024	0.2453	0.2453
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.036	0.497	0.497
Echinococcus multilocularis	tyrosine protein kinase csk	0.024	0.2453	0.2453
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Schistosoma mansoni	signal transduction protein lnk-related	0.036	0.497	0.497
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Brugia malayi	Tyrosine-protein kinase PR2	0.024	0.2453	0.2453
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.024	0.2453	0.2453
Loa Loa (eye worm)	hypothetical protein	0.024	0.2453	0.2453
Loa Loa (eye worm)	TK/FER protein kinase	0.0601	1	1
Onchocerca volvulus		0.0601	1	1
Echinococcus granulosus	N chimaerin	0.036	0.497	0.497
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Loa Loa (eye worm)	hypothetical protein	0.036	0.497	0.497
Echinococcus multilocularis	SH2 domain containing protein 7	0.036	0.497	0.497
Loa Loa (eye worm)	TK/FER protein kinase	0.024	0.2453	0.2453
Onchocerca volvulus		0.0289	0.3479	0.136
Loa Loa (eye worm)	TK/FER protein kinase	0.024	0.2453	0.2453
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0601	1	1
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.024	0.2453	0.2453
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.024	0.2453	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0601	1	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.024	0.2453	0.2453
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.024	0.2453	0.2453
Plasmodium falciparum	tyrosine kinase-like protein	0.024	0.2453	0.5
Loa Loa (eye worm)	hypothetical protein	0.036	0.497	0.497
Echinococcus multilocularis	heat shock protein 70	0.024	0.2453	0.2453
Echinococcus multilocularis	protein kinase	0.024	0.2453	0.2453
Onchocerca volvulus		0.0601	1	1
Schistosoma mansoni	vav2	0.036	0.497	0.497
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.024	0.2453	0.2453
Plasmodium vivax	tyrosine kinase-like protein, putative	0.024	0.2453	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.024	0.2453	0.2453
Trichomonas vaginalis	conserved hypothetical protein	0.024	0.2453	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0601	1	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.024	0.2453	0.2453
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.036	0.497	0.3334
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.036	0.497	0.497
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0601	1	1
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Schistosoma mansoni	inhibitor of apoptosis (iap) domain family member	0.0289	0.3479	0.3479
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.024	0.2453	0.2453
Loa Loa (eye worm)	TK protein kinase	0.024	0.2453	0.2453
Schistosoma mansoni	tensin	0.036	0.497	0.497
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.024	0.2453	0.2453
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.024	0.2453	0.2453
Loa Loa (eye worm)	hypothetical protein	0.036	0.497	0.497
Trichomonas vaginalis	CAMK family protein kinase	0.024	0.2453	0.5
Leishmania major	hypothetical protein, conserved	0.024	0.2453	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0601	1	1
Brugia malayi	hypothetical protein	0.024	0.2453	0.2453
Echinococcus multilocularis	inhibitor of apoptosis protein	0.0289	0.3479	0.3479
Echinococcus granulosus	signal transduction protein lnk realted	0.036	0.497	0.497
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0601	1	1
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.024	0.2453	0.2453
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Brugia malayi	Protein kinase domain containing protein	0.0601	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.024	0.2453	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.024	0.2453	0.2453
Schistosoma mansoni	tyrosine kinase	0.0601	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.036	0.497	0.497
Brugia malayi	SH2 domain containing protein	0.036	0.497	0.497
Plasmodium falciparum	protein kinase, putative	0.024	0.2453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.024	0.2453	0.2453
Echinococcus multilocularis	tensin	0.036	0.497	0.497
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.024	0.2453	0.2453
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.024	0.2453	0.5
Echinococcus granulosus	receptor type guanylyl cyclase	0.024	0.2453	0.2453
Schistosoma mansoni	tensin-related	0.036	0.497	0.497
Plasmodium vivax	protein kinase, putative	0.024	0.2453	0.5
Loa Loa (eye worm)	SRC-1	0.0601	1	1
Brugia malayi	Variant SH3 domain containing protein	0.036	0.497	0.497
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.036	0.497	0.497
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0601	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0601	1	1
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Loa Loa (eye worm)	TK/RYK protein kinase	0.024	0.2453	0.2453
Echinococcus multilocularis	protein tyrosine kinase	0.024	0.2453	0.2453
Schistosoma mansoni	SH2A	0.036	0.497	0.497
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0601	1	1
Loa Loa (eye worm)	hypothetical protein	0.036	0.497	0.497
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.024	0.2453	0.2453
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.024	0.2453	0.2453
Loa Loa (eye worm)	TK protein kinase	0.024	0.2453	0.2453
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Echinococcus granulosus	epidermal growth factor receptor	0.024	0.2453	0.2453
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Loa Loa (eye worm)	TK protein kinase	0.024	0.2453	0.2453
Echinococcus multilocularis	raf serine:threonine protein kinase	0.024	0.2453	0.2453
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0601	1	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.036	0.497	0.497
Echinococcus granulosus	tyrosine protein kinase Src42A	0.036	0.497	0.497
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.024	0.2453	0.2453
Schistosoma mansoni	adapter molecule crk	0.036	0.497	0.497
Onchocerca volvulus		0.0601	1	1
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.036	0.497	0.497
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.024	0.2453	0.5
Loa Loa (eye worm)	TK protein kinase	0.024	0.2453	0.2453
Schistosoma mansoni	tyrosine kinase	0.0601	1	1
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Schistosoma mansoni	protein kinase	0.024	0.2453	0.2453
Loa Loa (eye worm)	hypothetical protein	0.036	0.497	0.497
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Brugia malayi	STAT protein, DNA binding domain containing protein	0.036	0.497	0.497
Brugia malayi	Tyrosine-protein kinase abl-1	0.0601	1	1
Brugia malayi	Variant SH3 domain containing protein	0.036	0.497	0.497
Brugia malayi	Raf kinase	0.024	0.2453	0.2453
Echinococcus granulosus	protein tyrosine kinase	0.024	0.2453	0.2453
Echinococcus multilocularis	growth factor receptor bound protein 2	0.036	0.497	0.497
Schistosoma mansoni	tyrosine protein kinase	0.024	0.2453	0.2453
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.024	0.2453	0.2453
Schistosoma mansoni	hypothetical protein	0.0289	0.3479	0.3479
Echinococcus multilocularis	c src tyrosine kinase	0.0601	1	1
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0289	0.3479	0.3479
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0601	1	1
Loa Loa (eye worm)	hypothetical protein	0.0289	0.3479	0.3479
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Schistosoma mansoni	tyrosine kinase	0.0601	1	1
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0289	0.3479	0.3479
Brugia malayi	SH2 domain containing protein	0.036	0.497	0.497
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0601	1	1
Echinococcus granulosus	c src tyrosine kinase	0.0601	1	1
Brugia malayi	Tensin	0.036	0.497	0.497
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0601	1	1
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0601	1	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.024	0.2453	0.2453
Loa Loa (eye worm)	hypothetical protein	0.024	0.2453	0.2453
Trichomonas vaginalis	protein kinase atn1, putative	0.024	0.2453	0.5
Echinococcus granulosus	natriuretic peptide receptor 1	0.024	0.2453	0.2453
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.024	0.2453	0.2453
Brugia malayi	hypothetical protein	0.0601	1	1
Echinococcus multilocularis	activin receptor type	0.024	0.2453	0.2453
Echinococcus multilocularis	SH2 motif	0.036	0.497	0.497
Leishmania major	protein kinase, putative	0.024	0.2453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Schistosoma mansoni	hypothetical protein	0.036	0.497	0.497
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Leishmania major	protein kinase, putative	0.024	0.2453	0.5
Loa Loa (eye worm)	hypothetical protein	0.024	0.2453	0.2453
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.036	0.497	0.497
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.024	0.2453	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.024	0.2453	0.2453
Loa Loa (eye worm)	hypothetical protein	0.036	0.497	0.497
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Brugia malayi	RhoGAP domain containing protein	0.036	0.497	0.497
Echinococcus granulosus	NCK adaptor protein	0.036	0.497	0.497
Loa Loa (eye worm)	STAT protein	0.036	0.497	0.497
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0601	1	1
Giardia lamblia	Kinase, NEK	0.024	0.2453	0.5
Brugia malayi	hypothetical protein	0.036	0.497	0.497
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.036	0.497	0.497
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.024	0.2453	0.5
Echinococcus multilocularis	N chimaerin	0.036	0.497	0.497
Onchocerca volvulus		0.036	0.497	0.3334
Toxoplasma gondii	protein kinase domain-containing protein	0.024	0.2453	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.036	0.497	0.497
Trichomonas vaginalis	TK family protein kinase	0.024	0.2453	0.5
Echinococcus granulosus	tyrosine protein kinase HCK	0.024	0.2453	0.2453
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.024	0.2453	0.2453
Schistosoma mansoni	protein kinase	0.024	0.2453	0.2453
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.024	0.2453	0.5
Onchocerca volvulus		0.036	0.497	0.3334
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0601	1	1
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Loa Loa (eye worm)	protein kinase domain-containing protein	0.024	0.2453	0.2453
Schistosoma mansoni	inhibitor of apoptosis protein	0.0289	0.3479	0.3479
Echinococcus multilocularis	NCK adaptor protein	0.036	0.497	0.497
Echinococcus multilocularis	tyrosine protein kinase csk	0.024	0.2453	0.2453
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Loa Loa (eye worm)	hypothetical protein	0.036	0.497	0.497
Echinococcus granulosus	baculoviral IAP repeat containing protein	0.0289	0.3479	0.3479
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0601	1	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.024	0.2453	0.2453
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Trypanosoma brucei	Pseudokinase, putative	0.024	0.2453	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0601	1	1
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.024	0.2453	0.2453
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.024	0.2453	0.2453
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Entamoeba histolytica	SH2 domain containing protein	0.036	0.497	0.3334
Echinococcus multilocularis	tyrosine protein kinase	0.024	0.2453	0.2453
Loa Loa (eye worm)	TK/FER protein kinase	0.0601	1	1
Loa Loa (eye worm)	TK protein kinase	0.024	0.2453	0.2453
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.036	0.497	0.497
Brugia malayi	tRNA modification GTPase TrmE family protein	0.036	0.497	0.497
Schistosoma mansoni	tensin-related	0.036	0.497	0.497
Echinococcus multilocularis	protein kinase	0.024	0.2453	0.2453
Schistosoma mansoni	protein kinase	0.024	0.2453	0.2453
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.024	0.2453	0.2453
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Echinococcus multilocularis	kinase suppressor of Ras 1	0.024	0.2453	0.2453
Loa Loa (eye worm)	TK protein kinase	0.024	0.2453	0.2453
Echinococcus multilocularis	tyrosine kinase	0.0601	1	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.024	0.2453	0.2453
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Loa Loa (eye worm)	hypothetical protein	0.024	0.2453	0.2453
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.024	0.2453	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.024	0.2453	0.2453
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Schistosoma mansoni	protein tyrosine kinase	0.024	0.2453	0.2453
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0601	1	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.024	0.2453	0.2453
Loa Loa (eye worm)	TK/FER protein kinase	0.0601	1	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.036	0.497	0.497
Loa Loa (eye worm)	TK protein kinase	0.024	0.2453	0.2453
Echinococcus multilocularis	FL cytokine receptor	0.024	0.2453	0.2453
Echinococcus granulosus	hypothetical protein	0.036	0.497	0.497
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.024	0.2453	0.2453
Onchocerca volvulus		0.036	0.497	0.3334
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.024	0.2453	0.2453
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.024	0.2453	0.5
Schistosoma mansoni	tensin	0.036	0.497	0.497
Echinococcus granulosus	tensin	0.036	0.497	0.497
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.024	0.2453	0.2453
Brugia malayi	Protein kinase domain containing protein	0.0601	1	1
Loa Loa (eye worm)	hypothetical protein	0.024	0.2453	0.2453
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.036	0.497	0.497
Loa Loa (eye worm)	RGC/RGC protein kinase	0.024	0.2453	0.2453
Schistosoma mansoni	hypothetical protein	0.036	0.497	0.497
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Schistosoma mansoni	protein kinase	0.024	0.2453	0.2453
Loa Loa (eye worm)	hypothetical protein	0.0601	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.024	0.2453	0.2453
Schistosoma mansoni	protein kinase	0.024	0.2453	0.2453
Loa Loa (eye worm)	TK protein kinase	0.024	0.2453	0.2453
Trichomonas vaginalis	STE family protein kinase	0.024	0.2453	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0601	1	1
Brugia malayi	Protein kinase domain containing protein	0.0601	1	1
Echinococcus granulosus	activin receptor type	0.024	0.2453	0.2453
Echinococcus multilocularis	protein KINase family member (kin 25)	0.024	0.2453	0.2453
Brugia malayi	SH2 domain containing protein	0.036	0.497	0.497
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.036	0.497	0.497
Loa Loa (eye worm)	SH2 domain-containing protein	0.036	0.497	0.497
Loa Loa (eye worm)	TK/Met protein kinase	0.024	0.2453	0.2453
Echinococcus granulosus	inhibitor of apoptosis protein	0.0289	0.3479	0.3479
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.036	0.497	0.497
Brugia malayi	SH2 domain containing protein	0.0601	1	1
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Loa Loa (eye worm)	hypothetical protein	0.036	0.497	0.497
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.036	0.497	0.497
Loa Loa (eye worm)	TK/FER protein kinase	0.0601	1	1
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.024	0.2453	0.5
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.036	0.497	0.497
Brugia malayi	SH2 domain containing protein	0.0601	1	1
Onchocerca volvulus	Deterin homolog	0.0289	0.3479	0.136
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Schistosoma mansoni	protein kinase	0.024	0.2453	0.2453
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.024	0.2453	0.2453
Echinococcus granulosus	SH2 motif	0.036	0.497	0.497
Brugia malayi	protein-tyrosine kinase	0.0601	1	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.036	0.497	0.497
Brugia malayi	Guanylyl cyclase protein 23	0.024	0.2453	0.2453
Loa Loa (eye worm)	TK/FER protein kinase	0.0601	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.024	0.2453	0.2453
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Loa Loa (eye worm)	TK/FAK protein kinase	0.024	0.2453	0.2453
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Brugia malayi	bone morphogenetic protein type 1 receptor	0.024	0.2453	0.2453
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.024	0.2453	0.2453
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.024	0.2453	0.2453
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Echinococcus multilocularis	insulin receptor	0.024	0.2453	0.2453
Brugia malayi	SH2 domain containing protein	0.036	0.497	0.497
Echinococcus multilocularis	epidermal growth factor receptor	0.024	0.2453	0.2453
Loa Loa (eye worm)	hypothetical protein	0.024	0.2453	0.2453
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0601	1	1
Echinococcus multilocularis	baculoviral IAP repeat containing protein	0.0289	0.3479	0.3479
Echinococcus granulosus	tyrosine kinase	0.0601	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.024	0.2453	0.2453
Schistosoma mansoni	ephrin receptor	0.024	0.2453	0.2453
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.024	0.2453	0.2453
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Loa Loa (eye worm)	TK/FER protein kinase	0.024	0.2453	0.2453
Loa Loa (eye worm)	hypothetical protein	0.024	0.2453	0.2453
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.024	0.2453	0.2453
Brugia malayi	Immunoglobulin I-set domain containing protein	0.024	0.2453	0.2453
Loa Loa (eye worm)	TK/CSK protein kinase	0.024	0.2453	0.2453
Echinococcus multilocularis	tyrosine protein kinase HCK	0.024	0.2453	0.2453
Trichomonas vaginalis	conserved hypothetical protein	0.024	0.2453	0.5
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.036	0.497	0.497
Schistosoma mansoni	suppressor of cytokine signaling	0.036	0.497	0.497
Loa Loa (eye worm)	serine/threonine protein kinase	0.024	0.2453	0.2453
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0601	1	1
Trypanosoma brucei	protein kinase, putative	0.024	0.2453	0.5
Echinococcus granulosus	SH2 domain containing protein 7	0.036	0.497	0.497
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Schistosoma mansoni	protein kinase	0.024	0.2453	0.2453
Onchocerca volvulus		0.0601	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.024	0.2453	0.5
Loa Loa (eye worm)	hypothetical protein	0.024	0.2453	0.2453
Loa Loa (eye worm)	hypothetical protein	0.024	0.2453	0.2453
Loa Loa (eye worm)	RGC/RGC protein kinase	0.024	0.2453	0.2453
Echinococcus multilocularis	activated cdc42 kinase 1	0.024	0.2453	0.2453
Loa Loa (eye worm)	hypothetical protein	0.024	0.2453	0.2453
Trichomonas vaginalis	conserved hypothetical protein	0.024	0.2453	0.5
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.036	0.497	0.3334
Brugia malayi	SH2 domain containing protein	0.036	0.497	0.497
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.024	0.2453	0.2453
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.036	0.497	0.497
Onchocerca volvulus		0.0601	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.024	0.2453	0.2453
Trichomonas vaginalis	conserved hypothetical protein	0.024	0.2453	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.024	0.2453	0.2453
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.036	0.497	0.497
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0601	1	1
Entamoeba histolytica	protein kinase, putative	0.036	0.497	0.3334
Onchocerca volvulus		0.036	0.497	0.3334
Echinococcus granulosus	insulin receptor	0.024	0.2453	0.2453
Echinococcus multilocularis		0.036	0.497	0.497
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.036	0.497	0.497
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.024	0.2453	0.2453
Echinococcus granulosus	retinal guanylyl cyclase 2	0.024	0.2453	0.2453
Brugia malayi	Variant SH3 domain containing protein	0.036	0.497	0.497
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.024	0.2453	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0601	1	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0601	1	1
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0601	1	1
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Onchocerca volvulus		0.036	0.497	0.3334
Echinococcus multilocularis	natriuretic peptide receptor 1	0.024	0.2453	0.2453
Brugia malayi	SH2 domain containing protein	0.036	0.497	0.497
Schistosoma mansoni	protein kinase	0.024	0.2453	0.2453
Echinococcus granulosus	retinal guanylyl cyclase 2	0.024	0.2453	0.2453
Schistosoma mansoni	protein kinase	0.024	0.2453	0.2453
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Echinococcus granulosus	SH2 domain containing adapter protein F	0.036	0.497	0.497
Loa Loa (eye worm)	hypothetical protein	0.036	0.497	0.497
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.024	0.2453	0.2453
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.024	0.2453	0.2453
Schistosoma mansoni	growth factor receptor-bound protein	0.036	0.497	0.497
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.024	0.2453	0.2453
Schistosoma mansoni	protein kinase	0.024	0.2453	0.2453
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Schistosoma mansoni	shc transforming protein	0.036	0.497	0.497
Loa Loa (eye worm)	TK protein kinase	0.0601	1	1
Brugia malayi	hypothetical protein	0.024	0.2453	0.2453
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.024	0.2453	0.5
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Loa Loa (eye worm)	hypothetical protein	0.036	0.497	0.497
Echinococcus multilocularis	tyrosine kinase	0.024	0.2453	0.2453
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Loa Loa (eye worm)	TK/ROR protein kinase	0.024	0.2453	0.2453
Echinococcus multilocularis	SHC transforming protein 3	0.036	0.497	0.497
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.024	0.2453	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.036	0.497	0.497
Schistosoma mansoni	tyrosine kinase	0.0601	1	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.024	0.2453	0.2453
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.024	0.2453	0.2453
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Echinococcus multilocularis	receptor type guanylyl cyclase	0.024	0.2453	0.2453
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Echinococcus granulosus	growth factor receptor bound protein 2	0.036	0.497	0.497
Loa Loa (eye worm)	hypothetical protein	0.036	0.497	0.497
Giardia lamblia	Kinase, NEK	0.024	0.2453	0.5
Schistosoma mansoni	GTPase activating protein	0.036	0.497	0.497
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.036	0.497	0.497
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.024	0.2453	0.2453
Echinococcus granulosus	integrin linked protein kinase	0.024	0.2453	0.2453
Brugia malayi	ephrin receptor 1 precursor	0.024	0.2453	0.2453
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0601	1	1
Brugia malayi	Sex muscle abnormal protein 5	0.036	0.497	0.497
Toxoplasma gondii	protein kinase	0.024	0.2453	0.5
Loa Loa (eye worm)	hypothetical protein	0.036	0.497	0.497
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.024	0.2453	0.2453
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Brugia malayi	SRC-1	0.0601	1	1
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Loa Loa (eye worm)	hypothetical protein	0.024	0.2453	0.2453
Schistosoma mansoni	suppressor of cytokine signaling	0.036	0.497	0.497
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Onchocerca volvulus		0.036	0.497	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.024	0.2453	0.5
Echinococcus granulosus	kinase suppressor of Ras 1	0.024	0.2453	0.2453
Echinococcus granulosus	tyrosine kinase	0.024	0.2453	0.2453
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.024	0.2453	0.2453
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Echinococcus multilocularis	integrin linked protein kinase	0.024	0.2453	0.2453
Brugia malayi	C-terminal src kinase protein 1	0.024	0.2453	0.2453
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Schistosoma mansoni	nck2/grb4	0.036	0.497	0.497
Echinococcus multilocularis	tyrosine protein kinase pr2	0.024	0.2453	0.2453
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Onchocerca volvulus		0.0601	1	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.024	0.2453	0.2453
Echinococcus granulosus	tyrosine protein kinase pr2	0.024	0.2453	0.2453
Echinococcus multilocularis	tyrosine protein kinase csk	0.024	0.2453	0.2453
Loa Loa (eye worm)	hypothetical protein	0.0289	0.3479	0.3479
Echinococcus granulosus	SH2 motif	0.036	0.497	0.497
Loa Loa (eye worm)	RGC/RGC protein kinase	0.024	0.2453	0.2453
Schistosoma mansoni	serine/threonine protein kinase	0.024	0.2453	0.2453
Loa Loa (eye worm)	TK/EPH protein kinase	0.024	0.2453	0.2453
Loa Loa (eye worm)	hypothetical protein	0.024	0.2453	0.2453
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.024	0.2453	0.2453
Loa Loa (eye worm)	hypothetical protein	0.036	0.497	0.497
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.036	0.497	0.497
Loa Loa (eye worm)	hypothetical protein	0.036	0.497	0.497
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.024	0.2453	0.2453
Brugia malayi	Protein kinase domain containing protein	0.0601	1	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.024	0.2453	0.2453
Loa Loa (eye worm)	hypothetical protein	0.036	0.497	0.497
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0601	1	1
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Brugia malayi	Variant SH3 domain containing protein	0.036	0.497	0.497
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.024	0.2453	0.2453
Schistosoma mansoni	ephrin receptor	0.024	0.2453	0.2453
Giardia lamblia	Kinase	0.024	0.2453	0.5
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Trichomonas vaginalis	AGC family protein kinase	0.024	0.2453	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0601	1	1
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Schistosoma mansoni	hypothetical protein	0.024	0.2453	0.2453
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.024	0.2453	0.2453
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.024	0.2453	0.2453
Schistosoma mansoni	tyrosine kinase	0.0601	1	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.024	0.2453	0.5
Echinococcus granulosus	protein kinase	0.024	0.2453	0.2453
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.024	0.2453	0.2453
Toxoplasma gondii	STE kinase	0.024	0.2453	0.5
Echinococcus granulosus	fibroblast growth factor receptor 4	0.024	0.2453	0.2453
Echinococcus granulosus	epidermal growth factor receptor	0.024	0.2453	0.2453
Schistosoma mansoni	serine/threonine protein kinase	0.024	0.2453	0.2453
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Schistosoma mansoni	serine/threonine RGC	0.024	0.2453	0.2453
Plasmodium falciparum	protein kinase, putative	0.024	0.2453	0.5
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Echinococcus multilocularis	SH2 motif	0.036	0.497	0.497
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.024	0.2453	0.2453
Brugia malayi	cytokine inducible SH2-containing protein 5	0.036	0.497	0.497
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0601	1	1
Giardia lamblia	Protein 21.1	0.024	0.2453	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.036	0.497	0.497
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.024	0.2453	0.2453
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Echinococcus multilocularis	SH2 motif	0.036	0.497	0.497
Loa Loa (eye worm)	TK/ALK protein kinase	0.024	0.2453	0.2453
Loa Loa (eye worm)	TK/DDR protein kinase	0.024	0.2453	0.2453
Echinococcus granulosus	ephrin type A receptor 4 A	0.024	0.2453	0.2453
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0601	1	1
Echinococcus granulosus	tyrosine kinase	0.0601	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.036	0.497	0.497
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.024	0.2453	0.2453
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0601	1	1
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Schistosoma mansoni	protein kinase	0.024	0.2453	0.2453
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.036	0.497	0.497
Trypanosoma cruzi	protein kinase, putative	0.024	0.2453	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.024	0.2453	0.2453
Loa Loa (eye worm)	TK/FER protein kinase	0.0601	1	1
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.036	0.497	0.497
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Schistosoma mansoni	tensin	0.036	0.497	0.497
Loa Loa (eye worm)	TK/FER protein kinase	0.0601	1	1
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.024	0.2453	0.2453
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0601	1	1
Plasmodium falciparum	protein kinase, putative	0.024	0.2453	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.036	0.497	0.497
Trypanosoma cruzi	protein kinase, putative	0.024	0.2453	0.5
Loa Loa (eye worm)	TK protein kinase	0.024	0.2453	0.2453
Brugia malayi	integrin-linked kinase	0.024	0.2453	0.2453
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.024	0.2453	0.2453
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0601	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0601	1	1
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Brugia malayi	Furin-like cysteine rich region family protein	0.024	0.2453	0.2453
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.036	0.497	0.497
Trichomonas vaginalis	TKL family protein kinase	0.024	0.2453	0.5
Schistosoma mansoni	tyrosine kinase	0.024	0.2453	0.2453
Schistosoma mansoni	tyrosine kinase	0.0601	1	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0601	1	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.036	0.497	0.3334
Brugia malayi	Receptor family ligand binding region containing protein	0.024	0.2453	0.2453
Brugia malayi	Protein kinase domain containing protein	0.024	0.2453	0.2453
Loa Loa (eye worm)	SH2 domain-containing protein	0.036	0.497	0.497
Brugia malayi	SH2 domain containing protein	0.036	0.497	0.497

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.024 uM	Inhibition of FAAH in Sprague-Dawley rat brain microsomes assessed as N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide conversion to 4-pyren-1-ylbutanoic acid preincubated for 10 mins measured after 45 mins by HPLC analysis	ChEMBL.	23455058
IC50 (binding)	= 0.067 uM	Inhibition of human recombinant MAGL-mediated 1,3-dihydroxypropan-1-yl 4-pyren-1-ylbutanoate conversion to 4-pyren-1-ylbutanoic acid preincubated for 15 mins measured after 45 mins by HPLC analysis	ChEMBL.	23455058

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2376217

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1765654