TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 339.349 | Formula: C17H17N5O3
H donors: 0 H acceptors: 4 LogP: 3.18 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)Oc1ccc(cc1)c1nnn(n1)C(=O)N(C)C
InChi: 1S/C17H17N5O3/c1-21(2)17(23)22-19-16(18-20-22)12-4-6-14(7-5-12)25-15-10-8-13(24-3)9-11-15/h4-11H,1-3H3
InChiKey: AUFQROVGLPCMPI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Anandamide amidohydrolase	Starlite/ChEMBL	References
Homo sapiens	monoglyceride lipase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	amidase	Get druggable targets OG5_127783	All targets in OG5_127783
Leishmania major	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania donovani	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	Get druggable targets OG5_127037	All targets in OG5_127037
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	similar to YJU3	Get druggable targets OG5_127037	All targets in OG5_127037
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania infantum	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Echinococcus granulosus	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	similar to YJU3	Get druggable targets OG5_127037	All targets in OG5_127037
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium tuberculosis	Possible lysophospholipase	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania mexicana	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Echinococcus multilocularis	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Schistosoma mansoni	fatty-acid amide hydrolase	Get druggable targets OG5_127783	All targets in OG5_127783
Trypanosoma brucei	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma mansoni	amidase	Get druggable targets OG5_127783	All targets in OG5_127783
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania braziliensis	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Plasmodium falciparum	esterase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei gambiense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Echinococcus multilocularis	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Mycobacterium ulcerans	lysophospholipase	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium vivax	PST-A protein	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma cruzi	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Echinococcus granulosus	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Trypanosoma brucei gambiense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	valacyclovir hydrolase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma japonicum	ko:K01175 fatty acid amide hydrolase [EC:3.1.-.-], putative	Get druggable targets OG5_127783	All targets in OG5_127783

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Anandamide amidohydrolase	579 aa	539 aa	34.7 %
Echinococcus multilocularis	fatty acid amide hydrolase 1	Anandamide amidohydrolase	579 aa	470 aa	28.3 %
Plasmodium falciparum	esterase, putative	monoglyceride lipase	303 aa	254 aa	19.7 %
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Anandamide amidohydrolase	579 aa	499 aa	24.6 %
Echinococcus granulosus	fatty acid amide hydrolase 1	Anandamide amidohydrolase	579 aa	470 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0187	0.1777	0.1777
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0187	0.1777	0.1777
Echinococcus multilocularis	tyrosine protein kinase	0.0187	0.1777	0.1777
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0482	1	1
Schistosoma mansoni	protein kinase	0.0187	0.1777	0.1777
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0187	0.1777	0.1777
Schistosoma mansoni	protein kinase	0.0187	0.1777	0.1777
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0482	1	1
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0187	0.1777	0.1777
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0295	0.4794	0.4794
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0295	0.4794	0.4794
Onchocerca volvulus		0.0295	0.4794	0.3669
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0187	0.1777	0.1777
Trichomonas vaginalis	conserved hypothetical protein	0.0187	0.1777	0.5
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Loa Loa (eye worm)	TK protein kinase	0.0187	0.1777	0.1777
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0187	0.1777	0.1777
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0295	0.4794	0.4794
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0187	0.1777	0.1777
Loa Loa (eye worm)	TK protein kinase	0.0187	0.1777	0.1777
Schistosoma mansoni	nck2/grb4	0.0295	0.4794	0.4794
Schistosoma mansoni	serine/threonine RGC	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Loa Loa (eye worm)	TK/ALK protein kinase	0.0187	0.1777	0.1777
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0295	0.4794	0.4794
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0187	0.1777	0.1777
Schistosoma mansoni	tyrosine kinase	0.0482	1	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0295	0.4794	0.4794
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0295	0.4794	0.4794
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0187	0.1777	0.1777
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Loa Loa (eye worm)	SH2 domain-containing protein	0.0295	0.4794	0.4794
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0482	1	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0187	0.1777	0.1777
Loa Loa (eye worm)	hypothetical protein	0.0295	0.4794	0.4794
Loa Loa (eye worm)	hypothetical protein	0.0295	0.4794	0.4794
Schistosoma mansoni	protein kinase	0.0187	0.1777	0.1777
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0482	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0295	0.4794	0.4794
Echinococcus multilocularis	activin receptor type	0.0187	0.1777	0.1777
Plasmodium vivax	protein kinase, putative	0.0187	0.1777	0.5
Echinococcus granulosus	tyrosine protein kinase HCK	0.0187	0.1777	0.1777
Echinococcus granulosus	natriuretic peptide receptor 1	0.0187	0.1777	0.1777
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0482	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0295	0.4794	0.4794
Loa Loa (eye worm)	TK/FER protein kinase	0.0187	0.1777	0.1777
Loa Loa (eye worm)	TK/Met protein kinase	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0187	0.1777	0.1777
Loa Loa (eye worm)	TK/DDR protein kinase	0.0187	0.1777	0.1777
Leishmania major	protein kinase, putative	0.0187	0.1777	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0187	0.1777	0.1777
Loa Loa (eye worm)	hypothetical protein	0.0187	0.1777	0.1777
Echinococcus granulosus	protein kinase	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0187	0.1777	0.1777
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0187	0.1777	0.1777
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Loa Loa (eye worm)	hypothetical protein	0.0295	0.4794	0.4794
Brugia malayi	Furin-like cysteine rich region family protein	0.0187	0.1777	0.1777
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0482	1	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.4794	0.4794
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0187	0.1777	0.5
Schistosoma mansoni	adapter molecule crk	0.0295	0.4794	0.4794
Echinococcus granulosus	tyrosine protein kinase csk	0.0187	0.1777	0.1777
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0295	0.4794	0.4794
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0187	0.1777	0.1777
Brugia malayi	Tyrosine-protein kinase abl-1	0.0482	1	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0295	0.4794	0.4794
Echinococcus multilocularis	tyrosine protein kinase csk	0.0187	0.1777	0.1777
Schistosoma mansoni	protein kinase	0.0187	0.1777	0.1777
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0187	0.1777	0.1777
Schistosoma mansoni	suppressor of cytokine signaling	0.0295	0.4794	0.4794
Onchocerca volvulus		0.0295	0.4794	0.3669
Echinococcus granulosus	NCK adaptor protein	0.0295	0.4794	0.4794
Echinococcus multilocularis	protein tyrosine kinase	0.0187	0.1777	0.1777
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0187	0.1777	0.1777
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0187	0.1777	0.5
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Leishmania major	protein kinase, putative	0.0187	0.1777	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0187	0.1777	0.5
Loa Loa (eye worm)	TK/CSK protein kinase	0.0187	0.1777	0.1777
Schistosoma mansoni	tyrosine protein kinase	0.0187	0.1777	0.1777
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Loa Loa (eye worm)	SRC-1	0.0482	1	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0187	0.1777	0.5
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0187	0.1777	0.1777
Loa Loa (eye worm)	hypothetical protein	0.0295	0.4794	0.4794
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.0482	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0187	0.1777	0.5
Echinococcus multilocularis	signal transduction protein lnk realted	0.0295	0.4794	0.4794
Schistosoma mansoni	tensin	0.0295	0.4794	0.4794
Brugia malayi	Variant SH3 domain containing protein	0.0295	0.4794	0.4794
Echinococcus multilocularis	N chimaerin	0.0295	0.4794	0.4794
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0295	0.4794	0.4794
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0482	1	1
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Loa Loa (eye worm)	hypothetical protein	0.0482	1	1
Schistosoma mansoni	hypothetical protein	0.0187	0.1777	0.1777
Brugia malayi	C-terminal src kinase protein 1	0.0187	0.1777	0.1777
Plasmodium falciparum	protein kinase, putative	0.0187	0.1777	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0187	0.1777	0.1777
Loa Loa (eye worm)	TK/FER protein kinase	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.0187	0.1777	0.1777
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0187	0.1777	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0482	1	1
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0187	0.1777	0.1777
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0482	1	1
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Brugia malayi	Protein kinase domain containing protein	0.0482	1	1
Loa Loa (eye worm)	hypothetical protein	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0187	0.1777	0.1777
Onchocerca volvulus		0.0482	1	1
Loa Loa (eye worm)	hypothetical protein	0.0187	0.1777	0.1777
Brugia malayi	hypothetical protein	0.0482	1	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0187	0.1777	0.1777
Loa Loa (eye worm)	TK/EPH protein kinase	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Brugia malayi	Raf kinase	0.0187	0.1777	0.1777
Schistosoma mansoni	protein kinase	0.0187	0.1777	0.1777
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0187	0.1777	0.5
Echinococcus granulosus	hypothetical protein	0.0295	0.4794	0.4794
Onchocerca volvulus		0.0482	1	1
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0295	0.4794	0.4794
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0295	0.4794	0.4794
Schistosoma mansoni	tyrosine kinase	0.0482	1	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0187	0.1777	0.5
Schistosoma mansoni	protein kinase	0.0187	0.1777	0.1777
Echinococcus granulosus	expressed conserved protein	0.0295	0.4794	0.4794
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0295	0.4794	0.4794
Schistosoma mansoni	tyrosine kinase	0.0482	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Echinococcus multilocularis	SHC transforming protein 3	0.0295	0.4794	0.4794
Schistosoma mansoni	GTPase activating protein	0.0295	0.4794	0.4794
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Schistosoma mansoni	serine/threonine protein kinase	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0187	0.1777	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0187	0.1777	0.1777
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0187	0.1777	0.1777
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0187	0.1777	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0187	0.1777	0.5
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0295	0.4794	0.4794
Echinococcus granulosus	tyrosine protein kinase pr2	0.0187	0.1777	0.1777
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0187	0.1777	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0295	0.4794	0.4794
Trypanosoma cruzi	protein kinase, putative	0.0187	0.1777	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0482	1	1
Brugia malayi	SH2 domain containing protein	0.0482	1	1
Brugia malayi	SH2 domain containing protein	0.0295	0.4794	0.4794
Echinococcus multilocularis	tyrosine kinase	0.0187	0.1777	0.1777
Loa Loa (eye worm)	hypothetical protein	0.0295	0.4794	0.4794
Loa Loa (eye worm)	TK protein kinase	0.0482	1	1
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Echinococcus granulosus	epidermal growth factor receptor	0.0187	0.1777	0.1777
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0482	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0295	0.4794	0.4794
Loa Loa (eye worm)	TK protein kinase	0.0187	0.1777	0.1777
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Trichomonas vaginalis	conserved hypothetical protein	0.0187	0.1777	0.5
Schistosoma mansoni	tensin	0.0295	0.4794	0.4794
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0295	0.4794	0.4794
Echinococcus multilocularis	epidermal growth factor receptor	0.0187	0.1777	0.1777
Loa Loa (eye worm)	TK/FER protein kinase	0.0482	1	1
Giardia lamblia	Kinase, NEK	0.0187	0.1777	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0482	1	1
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0482	1	1
Onchocerca volvulus		0.0295	0.4794	0.3669
Echinococcus granulosus	tensin	0.0295	0.4794	0.4794
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0187	0.1777	0.1777
Onchocerca volvulus		0.0295	0.4794	0.3669
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Echinococcus granulosus	SH2 motif	0.0295	0.4794	0.4794
Loa Loa (eye worm)	hypothetical protein	0.0187	0.1777	0.1777
Echinococcus granulosus	signal transduction protein lnk realted	0.0295	0.4794	0.4794
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0295	0.4794	0.4794
Echinococcus granulosus	receptor type guanylyl cyclase	0.0187	0.1777	0.1777
Loa Loa (eye worm)	SH2 domain-containing protein	0.0295	0.4794	0.4794
Loa Loa (eye worm)	hypothetical protein	0.0187	0.1777	0.1777
Echinococcus granulosus	c src tyrosine kinase	0.0482	1	1
Loa Loa (eye worm)	TK protein kinase	0.0187	0.1777	0.1777
Onchocerca volvulus		0.0295	0.4794	0.3669
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0295	0.4794	0.4794
Loa Loa (eye worm)	TK/FER protein kinase	0.0187	0.1777	0.1777
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0295	0.4794	0.4794
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0187	0.1777	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0295	0.4794	0.4794
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0187	0.1777	0.1777
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0187	0.1777	0.5
Echinococcus granulosus	SH2 motif	0.0295	0.4794	0.4794
Schistosoma mansoni	protein tyrosine kinase	0.0187	0.1777	0.1777
Echinococcus granulosus	tyrosine protein kinase Blk	0.0482	1	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0482	1	1
Schistosoma mansoni	tyrosine kinase	0.0482	1	1
Brugia malayi	Tensin	0.0295	0.4794	0.4794
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0482	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0482	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0187	0.1777	0.5
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Schistosoma mansoni	protein kinase	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0482	1	1
Echinococcus multilocularis	SH2 motif	0.0295	0.4794	0.4794
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0187	0.1777	0.1777
Loa Loa (eye worm)	hypothetical protein	0.0187	0.1777	0.1777
Echinococcus multilocularis	tyrosine protein kinase shark	0.0482	1	1
Echinococcus granulosus	tyrosine kinase	0.0482	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0295	0.4794	0.4794
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0482	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0295	0.4794	0.4794
Echinococcus granulosus	activated cdc42 kinase 1	0.0187	0.1777	0.1777
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Loa Loa (eye worm)	TK protein kinase	0.0187	0.1777	0.1777
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0187	0.1777	0.5
Schistosoma mansoni	ephrin receptor	0.0187	0.1777	0.1777
Loa Loa (eye worm)	TK protein kinase	0.0187	0.1777	0.1777
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0295	0.4794	0.4794
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0482	1	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0187	0.1777	0.1777
Trichomonas vaginalis	conserved hypothetical protein	0.0187	0.1777	0.5
Schistosoma mansoni	protein kinase	0.0187	0.1777	0.1777
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0187	0.1777	0.1777
Giardia lamblia	Kinase	0.0187	0.1777	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0187	0.1777	0.1777
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0482	1	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.4794	0.4794
Echinococcus multilocularis	integrin linked protein kinase	0.0187	0.1777	0.1777
Echinococcus multilocularis	SH2 motif	0.0295	0.4794	0.4794
Echinococcus granulosus	SH2 domain containing protein 7	0.0295	0.4794	0.4794
Echinococcus granulosus	SHC transforming protein 3	0.0295	0.4794	0.4794
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Brugia malayi	Protein kinase domain containing protein	0.0482	1	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0187	0.1777	0.1777
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Brugia malayi	Protein kinase domain containing protein	0.0482	1	1
Brugia malayi	ephrin receptor 1 precursor	0.0187	0.1777	0.1777
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0187	0.1777	0.1777
Loa Loa (eye worm)	TK/FER protein kinase	0.0482	1	1
Schistosoma mansoni	hypothetical protein	0.0295	0.4794	0.4794
Echinococcus multilocularis	activated cdc42 kinase 1	0.0187	0.1777	0.1777
Echinococcus granulosus	protein tyrosine kinase	0.0187	0.1777	0.1777
Onchocerca volvulus		0.0482	1	1
Toxoplasma gondii	STE kinase	0.0187	0.1777	0.5
Loa Loa (eye worm)	hypothetical protein	0.0295	0.4794	0.4794
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0295	0.4794	0.4794
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Brugia malayi	SRC-1	0.0482	1	1
Loa Loa (eye worm)	hypothetical protein	0.0187	0.1777	0.1777
Echinococcus granulosus	tyrosine protein kinase csk	0.0187	0.1777	0.1777
Schistosoma mansoni	signal transduction protein lnk-related	0.0295	0.4794	0.4794
Onchocerca volvulus		0.0482	1	1
Schistosoma mansoni	tyrosine kinase	0.0482	1	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0187	0.1777	0.1777
Trichomonas vaginalis	conserved hypothetical protein	0.0187	0.1777	0.5
Echinococcus multilocularis	FL cytokine receptor	0.0187	0.1777	0.1777
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Entamoeba histolytica	protein kinase, putative	0.0295	0.4794	0.3669
Echinococcus multilocularis	tyrosine protein kinase csk	0.0187	0.1777	0.1777
Trypanosoma cruzi	protein kinase, putative	0.0187	0.1777	0.5
Loa Loa (eye worm)	hypothetical protein	0.0295	0.4794	0.4794
Loa Loa (eye worm)	TK/FER protein kinase	0.0187	0.1777	0.1777
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0482	1	1
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Loa Loa (eye worm)	hypothetical protein	0.0295	0.4794	0.4794
Echinococcus multilocularis	epidermal growth factor receptor	0.0187	0.1777	0.1777
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Loa Loa (eye worm)	hypothetical protein	0.0295	0.4794	0.4794
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0295	0.4794	0.4794
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0187	0.1777	0.1777
Echinococcus multilocularis	protein kinase	0.0187	0.1777	0.1777
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0187	0.1777	0.5
Echinococcus granulosus	N chimaerin	0.0295	0.4794	0.4794
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0295	0.4794	0.3669
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0187	0.1777	0.5
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0187	0.1777	0.1777
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0187	0.1777	0.1777
Loa Loa (eye worm)	hypothetical protein	0.0187	0.1777	0.1777
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0295	0.4794	0.4794
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Brugia malayi	integrin-linked kinase	0.0187	0.1777	0.1777
Brugia malayi	SH2 domain containing protein	0.0482	1	1
Onchocerca volvulus		0.0295	0.4794	0.3669
Echinococcus multilocularis	transfer RNA-Thr	0.0187	0.1777	0.1777
Brugia malayi	Protein kinase domain containing protein	0.0482	1	1
Entamoeba histolytica	SH2 domain containing protein	0.0295	0.4794	0.3669
Echinococcus granulosus	tyrosine protein kinase shark	0.0482	1	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0187	0.1777	0.1777
Loa Loa (eye worm)	hypothetical protein	0.0295	0.4794	0.4794
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0187	0.1777	0.1777
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0187	0.1777	0.1777
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0187	0.1777	0.1777
Trichomonas vaginalis	protein kinase atn1, putative	0.0187	0.1777	0.5
Loa Loa (eye worm)	TK protein kinase	0.0187	0.1777	0.1777
Loa Loa (eye worm)	TK/FER protein kinase	0.0482	1	1
Loa Loa (eye worm)	TK protein kinase	0.0187	0.1777	0.1777
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0187	0.1777	0.1777
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0482	1	1
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Schistosoma mansoni	serine/threonine protein kinase	0.0187	0.1777	0.1777
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0187	0.1777	0.1777
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0295	0.4794	0.3669
Echinococcus multilocularis	NCK adaptor protein	0.0295	0.4794	0.4794
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Schistosoma mansoni	tensin-related	0.0295	0.4794	0.4794
Echinococcus multilocularis	insulin receptor	0.0187	0.1777	0.1777
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0187	0.1777	0.1777
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0187	0.1777	0.1777
Trichomonas vaginalis	conserved hypothetical protein	0.0187	0.1777	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0187	0.1777	0.1777
Schistosoma mansoni	vav2	0.0295	0.4794	0.4794
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0187	0.1777	0.5
Schistosoma mansoni	SH2A	0.0295	0.4794	0.4794
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0187	0.1777	0.1777
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0482	1	1
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Leishmania major	hypothetical protein, conserved	0.0187	0.1777	0.5
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Schistosoma mansoni	ephrin receptor	0.0187	0.1777	0.1777
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0187	0.1777	0.1777
Onchocerca volvulus		0.0482	1	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0187	0.1777	0.1777
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0187	0.1777	0.1777
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Brugia malayi	SH2 domain containing protein	0.0295	0.4794	0.4794
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0187	0.1777	0.1777
Schistosoma mansoni	hypothetical protein	0.0295	0.4794	0.4794
Brugia malayi	SH2 domain containing protein	0.0295	0.4794	0.4794
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0482	1	1
Schistosoma mansoni	protein kinase	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Brugia malayi	protein-tyrosine kinase	0.0482	1	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0482	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0482	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Brugia malayi	Guanylyl cyclase protein 23	0.0187	0.1777	0.1777
Trichomonas vaginalis	TK family protein kinase	0.0187	0.1777	0.5
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Loa Loa (eye worm)	TK/FER protein kinase	0.0482	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0187	0.1777	0.1777
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0187	0.1777	0.1777
Echinococcus granulosus	growth factor receptor bound protein 2	0.0295	0.4794	0.4794
Schistosoma mansoni	tyrosine kinase	0.0482	1	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0187	0.1777	0.1777
Schistosoma mansoni	shc transforming protein	0.0295	0.4794	0.4794
Loa Loa (eye worm)	TK/FAK protein kinase	0.0187	0.1777	0.1777
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0187	0.1777	0.1777
Giardia lamblia	Kinase, NEK	0.0187	0.1777	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0295	0.4794	0.4794
Giardia lamblia	Protein 21.1	0.0187	0.1777	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0482	1	1
Loa Loa (eye worm)	hypothetical protein	0.0295	0.4794	0.4794
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0187	0.1777	0.1777
Echinococcus granulosus	tyrosine kinase	0.0482	1	1
Echinococcus multilocularis		0.0295	0.4794	0.4794
Brugia malayi	SH2 domain containing protein	0.0295	0.4794	0.4794
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0482	1	1
Brugia malayi	Sex muscle abnormal protein 5	0.0295	0.4794	0.4794
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0187	0.1777	0.1777
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0482	1	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.0187	0.1777	0.1777
Loa Loa (eye worm)	hypothetical protein	0.0187	0.1777	0.1777
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0295	0.4794	0.4794
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.0187	0.1777	0.1777
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0482	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0187	0.1777	0.1777
Brugia malayi	hypothetical protein	0.0187	0.1777	0.1777
Echinococcus multilocularis	heat shock protein 70	0.0187	0.1777	0.1777
Brugia malayi	hypothetical protein	0.0295	0.4794	0.4794
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0187	0.1777	0.1777
Loa Loa (eye worm)	TK/FER protein kinase	0.0187	0.1777	0.1777
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Echinococcus granulosus	tyrosine kinase	0.0187	0.1777	0.1777
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Echinococcus multilocularis	SH2 motif	0.0295	0.4794	0.4794
Brugia malayi	RhoGAP domain containing protein	0.0295	0.4794	0.4794
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0295	0.4794	0.4794
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0187	0.1777	0.1777
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0482	1	1
Echinococcus multilocularis	protein kinase	0.0187	0.1777	0.1777
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0295	0.4794	0.4794
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0187	0.1777	0.1777
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0295	0.4794	0.4794
Trypanosoma brucei	Pseudokinase, putative	0.0187	0.1777	0.5
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Schistosoma mansoni	growth factor receptor-bound protein	0.0295	0.4794	0.4794
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Echinococcus multilocularis	tyrosine kinase	0.0482	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0295	0.4794	0.4794
Loa Loa (eye worm)	hypothetical protein	0.0295	0.4794	0.4794
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Echinococcus granulosus	kinase suppressor of Ras 1	0.0187	0.1777	0.1777
Schistosoma mansoni	protein kinase	0.0187	0.1777	0.1777
Loa Loa (eye worm)	TK/FER protein kinase	0.0187	0.1777	0.1777
Brugia malayi	SH2 domain containing protein	0.0295	0.4794	0.4794
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Loa Loa (eye worm)	STAT protein	0.0295	0.4794	0.4794
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0295	0.4794	0.4794
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0295	0.4794	0.4794
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0295	0.4794	0.3669
Brugia malayi	SH2 domain containing protein	0.0295	0.4794	0.4794
Schistosoma mansoni	suppressor of cytokine signaling	0.0295	0.4794	0.4794
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0187	0.1777	0.1777
Loa Loa (eye worm)	hypothetical protein	0.0295	0.4794	0.4794
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0482	1	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0295	0.4794	0.4794
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Echinococcus granulosus	insulin receptor	0.0187	0.1777	0.1777
Loa Loa (eye worm)	hypothetical protein	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Schistosoma mansoni	protein kinase	0.0187	0.1777	0.1777
Loa Loa (eye worm)	TK/RYK protein kinase	0.0187	0.1777	0.1777
Plasmodium falciparum	tyrosine kinase-like protein	0.0187	0.1777	0.5
Plasmodium falciparum	protein kinase, putative	0.0187	0.1777	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0482	1	1
Trypanosoma brucei	protein kinase, putative	0.0187	0.1777	0.5
Echinococcus granulosus	tyrosine protein kinase	0.0187	0.1777	0.1777
Schistosoma mansoni	tyrosine kinase	0.0187	0.1777	0.1777
Echinococcus granulosus	epidermal growth factor receptor	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Echinococcus multilocularis	tensin	0.0295	0.4794	0.4794
Loa Loa (eye worm)	TK/ROR protein kinase	0.0187	0.1777	0.1777
Plasmodium falciparum	protein kinase, putative	0.0187	0.1777	0.5
Schistosoma mansoni	tensin	0.0295	0.4794	0.4794
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0187	0.1777	0.1777
Loa Loa (eye worm)	TK/FER protein kinase	0.0482	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Echinococcus granulosus	activin receptor type	0.0187	0.1777	0.1777
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0187	0.1777	0.1777
Trichomonas vaginalis	STE family protein kinase	0.0187	0.1777	0.5
Loa Loa (eye worm)	hypothetical protein	0.0187	0.1777	0.1777
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0482	1	1
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0295	0.4794	0.4794
Loa Loa (eye worm)	TK protein kinase	0.0187	0.1777	0.1777
Brugia malayi	Tyrosine-protein kinase PR2	0.0187	0.1777	0.1777
Trichomonas vaginalis	CAMK family protein kinase	0.0187	0.1777	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0187	0.1777	0.1777
Echinococcus granulosus	tyrosine protein kinase Srms	0.0482	1	1
Brugia malayi	SH2 domain containing protein	0.0295	0.4794	0.4794
Echinococcus multilocularis	tensin	0.0295	0.4794	0.4794
Schistosoma mansoni	tensin-related	0.0295	0.4794	0.4794
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0482	1	1
Echinococcus granulosus	integrin linked protein kinase	0.0187	0.1777	0.1777
Echinococcus multilocularis	SH2 domain containing protein 7	0.0295	0.4794	0.4794
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Onchocerca volvulus		0.0482	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Loa Loa (eye worm)	serine/threonine protein kinase	0.0187	0.1777	0.1777
Brugia malayi	Variant SH3 domain containing protein	0.0295	0.4794	0.4794
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Toxoplasma gondii	protein kinase	0.0187	0.1777	0.5
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0187	0.1777	0.1777
Echinococcus multilocularis	tyrosine protein kinase csk	0.0187	0.1777	0.1777
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0187	0.1777	0.1777
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1777	0.1777
Brugia malayi	hypothetical protein	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0187	0.1777	0.1777
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Loa Loa (eye worm)	hypothetical protein	0.0187	0.1777	0.1777
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0482	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0187	0.1777	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0187	0.1777	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.013 uM	Inhibition of FAAH in Sprague-Dawley rat brain microsomes assessed as N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide conversion to 4-pyren-1-ylbutanoic acid preincubated for 10 mins measured after 45 mins by HPLC analysis	ChEMBL.	23455058
IC50 (binding)	= 0.19 uM	Inhibition of human recombinant MAGL-mediated 1,3-dihydroxypropan-1-yl 4-pyren-1-ylbutanoate conversion to 4-pyren-1-ylbutanoic acid preincubated for 15 mins measured after 45 mins by HPLC analysis	ChEMBL.	23455058

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2376218

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1765655