Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0044 | 0.0943 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0423 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase TAO1 | 0.0423 | 1 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0044 | 0.0943 | 0.5 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.004 | 0.0856 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0044 | 0.0943 | 0.5 |
Loa Loa (eye worm) | STE/STE20/TAO protein kinase | 0.0423 | 1 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0144 | 0.3345 | 0.2652 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0044 | 0.0943 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0044 | 0.0943 | 0.5 |
Brugia malayi | Serine/threonine-protein kinase SULU | 0.0423 | 1 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.004 | 0.0856 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase TAO1 | 0.0423 | 1 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.004 | 0.0856 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.