Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Ovis aries | Cyclooxygenase-2 | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.5932 | 1 | 1 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.5932 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.0095 | 0.0095 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.0095 | 0.0095 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0248 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0248 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.5932 | 1 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0248 | 0.0095 | 0.5 |
Onchocerca volvulus | Kinase homolog | 0.0193 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.0095 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0248 | 0.0095 | 0.0095 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.0095 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0248 | 0.0095 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0248 | 0.0095 | 0.0095 |
Schistosoma mansoni | protein kinase | 0.5932 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0248 | 0.0095 | 0.0095 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.5932 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0248 | 0.0095 | 0.0095 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4 uM | Inhibition of ovine COX2-mediated prostaglandin alpha production by enzyme immuno assay | ChEMBL. | 23528298 |
IC50 (binding) | > 100 uM | Inhibition of ovine COX1-mediated prostaglandin alpha production by enzyme immuno assay | ChEMBL. | 23528298 |
Ki (binding) | = 1 nM | Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydrase assay | ChEMBL. | 25442309 |
Ki (binding) | = 4.9 nM | Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydrase assay | ChEMBL. | 25442309 |
Ki (binding) | = 49 nM | Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay | ChEMBL. | 25442309 |
Ki (binding) | > 1000 nM | Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay | ChEMBL. | 25442309 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.