Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.1272 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0248 | 0.0999 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.0999 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1272 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0248 | 0.0999 | 0.0999 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.0999 | 0.0999 |
Onchocerca volvulus | Lysosome membrane protein 2 homolog | 0.1272 | 1 | 0.5 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.1272 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0134 | 0 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0248 | 0.0999 | 0.0999 |
Brugia malayi | hypothetical protein | 0.0481 | 0.3043 | 0.3043 |
Schistosoma mansoni | CD36-like class B scavenger receptor | 0.1272 | 1 | 1 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.1272 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0248 | 0.0999 | 0.0999 |
Echinococcus multilocularis | lysosome membrane protein 2 | 0.1272 | 1 | 1 |
Schistosoma mansoni | cd36 antigen | 0.0481 | 0.3043 | 0.3043 |
Schistosoma mansoni | scavenger receptor class B type-2 (sr-B2) | 0.1272 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.3043 | 0.3043 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.3043 | 0.3043 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0248 | 0.0999 | 0.0999 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.0999 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1272 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.0999 | 0.0999 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.1272 | 1 | 1 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.1272 | 1 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0248 | 0.0999 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.3043 | 0.3043 |
Brugia malayi | hypothetical protein | 0.0481 | 0.3043 | 0.3043 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.1272 | 1 | 1 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.1272 | 1 | 1 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.1272 | 1 | 1 |
Schistosoma mansoni | CD36-like class B scavenger receptor | 0.1272 | 1 | 1 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.1272 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0134 | 0 | 0.5 |
Echinococcus granulosus | lysosome membrane protein 2 | 0.1272 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0248 | 0.0999 | 0.0999 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.1272 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1272 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0248 | 0.0999 | 0.0999 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of ovine COX2-mediated prostaglandin alpha production by enzyme immuno assay | ChEMBL. | 23528298 |
IC50 (binding) | > 100 uM | Inhibition of ovine COX1-mediated prostaglandin alpha production by enzyme immuno assay | ChEMBL. | 23528298 |
Ki (binding) | = 0.68 nM | Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydrase assay | ChEMBL. | 25442309 |
Ki (binding) | = 27.6 nM | Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay | ChEMBL. | 25442309 |
Ki (binding) | = 29.3 nM | Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydrase assay | ChEMBL. | 25442309 |
Ki (binding) | = 176 nM | Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay | ChEMBL. | 25442309 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.