TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 454.494 | Formula: C24H27FN4O4
H donors: 2 H acceptors: 2 LogP: 3.2 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COCCOc1cc2ncc(c(c2cc1N1CCOCC1)Nc1ccc(cc1F)C)C(=O)N
InChi: 1S/C24H27FN4O4/c1-15-3-4-19(18(25)11-15)28-23-16-12-21(29-5-7-32-8-6-29)22(33-10-9-31-2)13-20(16)27-14-17(23)24(26)30/h3-4,11-14H,5-10H2,1-2H3,(H2,26,30)(H,27,28)
InChiKey: ZJTOGZMETAQOQK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	biogenic amine 5HT receptor	0.004	0.172	0.172
Echinococcus granulosus	voltage gated potassium channel	0.0013	0.0224	0.0224
Brugia malayi	ORL1-like opioid receptor	0.004	0.172	0.172
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.004	0.172	0.172
Echinococcus multilocularis	neuropeptide receptor	0.004	0.172	0.172
Echinococcus granulosus	serotonin receptor	0.004	0.172	0.172
Schistosoma mansoni	biogenic amine (5HT) receptor	0.004	0.172	0.172
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.172	0.172
Schistosoma mansoni	neuropeptide receptor	0.004	0.172	0.172
Schistosoma mansoni	amine GPCR	0.004	0.172	0.172
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.004	0.172	0.172
Schistosoma mansoni	biogenic amine receptor	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Echinococcus granulosus	somatostatin receptor	0.004	0.172	0.172
Leishmania major	beta tubulin	0.0192	1	0.5
Echinococcus multilocularis	tubulin subunit beta	0.0192	1	1
Onchocerca volvulus		0.004	0.172	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.172	0.172
Brugia malayi	neuropeptide F receptor	0.004	0.172	0.172
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.004	0.172	0.172
Trypanosoma brucei	beta tubulin	0.0192	1	0.5
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.004	0.172	0.172
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.1954	0.1954
Leishmania major	beta tubulin	0.0192	1	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.004	0.172	0.172
Echinococcus multilocularis	fmrfamide receptor	0.004	0.172	0.172
Echinococcus multilocularis	g protein coupled receptor	0.004	0.172	0.172
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.004	0.172	0.172
Echinococcus granulosus	Tubulin beta 2C chain	0.0192	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Trichomonas vaginalis	tubulin, putative	0.0192	1	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.004	0.172	0.172
Brugia malayi	RE15519p	0.004	0.172	0.172
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.1794	0.1794
Brugia malayi	hypothetical protein	0.004	0.172	0.172
Brugia malayi	Dopamine receptor protein 2	0.004	0.172	0.172
Echinococcus granulosus	biogenic amine 5HT receptor	0.004	0.172	0.172
Plasmodium falciparum	tubulin beta chain	0.0192	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Onchocerca volvulus		0.004	0.172	0.5
Echinococcus multilocularis	beta tubulin	0.0192	1	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.004	0.172	0.172
Schistosoma mansoni	biogenic amine receptor	0.004	0.172	0.172
Brugia malayi	AKH receptor	0.004	0.172	0.172
Echinococcus multilocularis	serotonin receptor	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.004	0.172	0.172
Echinococcus multilocularis	neuropeptides capa receptor	0.004	0.172	0.172
Leishmania major	beta tubulin	0.0192	1	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.004	0.172	0.172
Brugia malayi	putative neuropeptide receptor NPR1	0.004	0.172	0.172
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0192	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.004	0.172	0.172
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.004	0.172	0.172
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Giardia lamblia	Beta tubulin	0.0192	1	0.5
Echinococcus granulosus	fmrfamide receptor	0.004	0.172	0.172
Leishmania major	beta tubulin	0.0192	1	0.5
Leishmania major	beta tubulin	0.0192	1	0.5
Brugia malayi	Dopamine receptor protein 1	0.004	0.172	0.172
Schistosoma mansoni	opsin-like receptor	0.004	0.172	0.172
Leishmania major	beta tubulin	0.0192	1	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.004	0.172	0.172
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.172	0.172
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0192	1	1
Schistosoma mansoni	tubulin subunit beta	0.0192	1	1
Onchocerca volvulus		0.004	0.172	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Echinococcus granulosus	neuropeptides capa receptor	0.004	0.172	0.172
Loa Loa (eye worm)	melatonin receptor type 1A	0.004	0.172	0.172
Leishmania major	beta tubulin	0.0192	1	0.5
Schistosoma mansoni	histamine h1 receptor	0.004	0.172	0.172
Schistosoma mansoni	tubulin subunit beta	0.0192	1	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.1954	0.1954
Schistosoma mansoni	neuropeptide receptor	0.004	0.172	0.172
Echinococcus granulosus	Tubulin beta 2C chain	0.0192	1	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.004	0.172	0.172
Echinococcus granulosus	tm gpcr rhodopsin	0.004	0.172	0.172
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.004	0.172	0.172
Echinococcus multilocularis	Tubulin beta 2C chain	0.0192	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0192	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.004	0.172	0.172
Onchocerca volvulus		0.004	0.172	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.172	0.172
Echinococcus granulosus	sex peptide receptor	0.004	0.172	0.172
Leishmania major	beta tubulin	0.0192	1	0.5
Echinococcus granulosus	7TM GPCR rhodopsin	0.004	0.172	0.172
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.004	0.172	0.172
Trypanosoma brucei	beta tubulin	0.0192	1	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.004	0.172	0.172
Echinococcus multilocularis	G protein coupled receptor 139	0.004	0.172	0.172
Echinococcus granulosus	alpha 1A adrenergic receptor	0.004	0.172	0.172
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.004	0.172	0.172
Loa Loa (eye worm)	neuropeptide F receptor	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Echinococcus multilocularis	g protein coupled receptor	0.004	0.172	0.172
Echinococcus multilocularis	voltage gated potassium channel	0.0013	0.0224	0.0224
Echinococcus granulosus	beta tubulin	0.0192	1	1
Echinococcus granulosus	7tm_1 domain containing protein	0.004	0.172	0.172
Schistosoma mansoni	tubulin subunit beta	0.0192	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.172	0.172
Echinococcus multilocularis	Tubulin beta 2C chain	0.0192	1	1
Giardia lamblia	Beta tubulin	0.0192	1	0.5
Echinococcus multilocularis	orexin receptor type 2	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Schistosoma mansoni	amine GPCR	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Brugia malayi	hypothetical protein	0.004	0.172	0.172
Brugia malayi	Melatonin receptor type 1A	0.004	0.172	0.172
Echinococcus granulosus	G protein coupled receptor 139	0.004	0.172	0.172
Echinococcus granulosus	dro:myosuppressin receptor	0.004	0.172	0.172
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.004	0.172	0.172
Onchocerca volvulus		0.004	0.172	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Brugia malayi	hypothetical protein	0.004	0.172	0.172
Brugia malayi	Serotonin receptor	0.004	0.172	0.172
Echinococcus multilocularis	Tubulin beta 2C chain	0.0192	1	1
Echinococcus granulosus	g-protein coupled receptor	0.004	0.172	0.172
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.004	0.172	0.5
Brugia malayi	putative neuropeptide receptor	0.004	0.172	0.172
Schistosoma mansoni	neuropeptide receptor	0.004	0.172	0.172
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.004	0.172	0.172
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Schistosoma mansoni	amine GPCR	0.004	0.172	0.172
Onchocerca volvulus		0.004	0.172	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0224	0.0224
Brugia malayi	Dopamine receptor	0.004	0.172	0.172
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.004	0.172	0.172
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.004	0.172	0.172
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.172	0.172
Loa Loa (eye worm)	beta-tubulin	0.0192	1	1
Toxoplasma gondii	beta-1 tubulin, putative	0.0192	1	0.5
Onchocerca volvulus		0.004	0.172	0.5
Entamoeba histolytica	tubulin family protein	0.0192	1	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.172	0.172
Schistosoma mansoni	neuropeptide F-like receptor	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Schistosoma mansoni	hypothetical protein	0.004	0.172	0.172
Leishmania major	beta tubulin	0.0192	1	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0013	0.0224	0.0224
Plasmodium vivax	tubulin beta chain, putative	0.0192	1	0.5
Loa Loa (eye worm)	tubulin beta chain	0.0192	1	1
Echinococcus granulosus	neuropeptide receptor	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Echinococcus granulosus	peptide allatostatin:somatostatin	0.004	0.172	0.172
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.172	0.172
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.004	0.172	0.172
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.172	0.172
Loa Loa (eye worm)	tubulin beta-1 chain	0.0192	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Schistosoma mansoni	hypothetical protein	0.004	0.172	0.172
Schistosoma mansoni	hypothetical protein	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Leishmania major	beta tubulin	0.0192	1	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.004	0.172	0.172
Leishmania major	beta tubulin	0.0192	1	0.5
Schistosoma mansoni	hypothetical protein	0.004	0.172	0.172
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0224	0.0224
Echinococcus multilocularis	neuropeptide s receptor	0.004	0.172	0.172
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.004	0.172	0.172
Brugia malayi	Serotonin receptor	0.004	0.172	0.172
Echinococcus granulosus	neuropeptide FF receptor 2	0.004	0.172	0.172
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0013	0.0224	0.0224
Brugia malayi	G-protein coupled receptor	0.004	0.172	0.172
Echinococcus granulosus	Tubulin beta 2C chain	0.0192	1	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1632	0.1632
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Schistosoma mansoni	opsin-like receptor	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.172	0.172
Schistosoma mansoni	tubulin subunit beta	0.0192	1	1
Brugia malayi	sulfakinin receptor protein	0.004	0.172	0.172
Schistosoma mansoni	neuropeptide receptor	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Loa Loa (eye worm)	tubulin beta-2A chain	0.0192	1	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.004	0.172	0.172
Schistosoma mansoni	biogenic amine receptor	0.004	0.172	0.172
Loa Loa (eye worm)	TYRA-2 protein	0.004	0.172	0.172
Brugia malayi	hypothetical protein	0.004	0.172	0.172
Echinococcus multilocularis	fmrfamide receptor	0.004	0.172	0.172
Trichomonas vaginalis	tubulin beta chain, putative	0.0192	1	1
Brugia malayi	larval opioid receptor	0.004	0.172	0.172
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.004	0.172	0.172
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.172	0.172
Trypanosoma brucei	beta tubulin	0.0192	1	0.5
Brugia malayi	hypothetical protein	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Brugia malayi	Tachykinin-like peptides receptor 99D	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Echinococcus granulosus	allatostatin A receptor	0.004	0.172	0.172
Schistosoma mansoni	growth hormone secretagogue receptor	0.004	0.172	0.172
Echinococcus granulosus	tubulin beta 1 chain	0.0192	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.172	0.172
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.004	0.172	0.172
Leishmania major	beta tubulin	0.0192	1	0.5
Brugia malayi	hypothetical protein	0.004	0.172	0.172
Leishmania major	beta tubulin	0.0192	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.004	0.172	0.172
Echinococcus multilocularis	neuropeptide Y receptor	0.004	0.172	0.172
Echinococcus multilocularis	neuropeptide FF receptor 2	0.004	0.172	0.172
Echinococcus multilocularis	G-protein coupled receptor, putative	0.004	0.172	0.172
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.172	0.172
Leishmania major	beta tubulin	0.0192	1	0.5
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0192	1	1
Onchocerca volvulus		0.004	0.172	0.5
Leishmania major	beta tubulin	0.0192	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.172	0.172
Echinococcus granulosus	hypothetical protein	0.004	0.172	0.172
Echinococcus multilocularis	neuropeptides capa receptor	0.004	0.172	0.172
Echinococcus multilocularis	neuropeptide Y receptor	0.004	0.172	0.172
Schistosoma mansoni	amine GPCR	0.004	0.172	0.172
Onchocerca volvulus		0.004	0.172	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Onchocerca volvulus		0.004	0.172	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.1794	0.1794
Echinococcus multilocularis	Tubulin beta 2C chain	0.0192	1	1
Brugia malayi	hypothetical protein	0.004	0.172	0.172
Echinococcus granulosus	Tubulin beta 2C chain	0.0192	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.172	0.172
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0013	0.0224	0.0224
Leishmania major	beta tubulin	0.0192	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Trypanosoma brucei	beta tubulin	0.0192	1	0.5
Echinococcus multilocularis	dro:myosuppressin receptor	0.004	0.172	0.172
Toxoplasma gondii	beta-tubulin, putative	0.0192	1	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.004	0.172	0.172
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.2178	0.2178
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.1954	0.1954
Echinococcus multilocularis	neuropeptide receptor A26	0.004	0.172	0.172
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.004	0.172	0.172
Loa Loa (eye worm)	BEN-1 protein	0.0192	1	1
Brugia malayi	hypothetical protein	0.004	0.172	0.172
Echinococcus granulosus	g protein coupled receptor	0.004	0.172	0.172
Echinococcus granulosus	g protein coupled receptor	0.004	0.172	0.172
Echinococcus multilocularis	g protein coupled receptor	0.004	0.172	0.172
Echinococcus multilocularis	beta tubulin	0.0192	1	1
Echinococcus multilocularis	somatostatin receptor	0.004	0.172	0.172
Schistosoma mansoni	neuropeptide f receptor 76f	0.004	0.172	0.172
Schistosoma mansoni	tubulin subunit beta	0.0192	1	1
Brugia malayi	GnHR receptor homolog	0.004	0.172	0.172
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.172	0.172
Echinococcus granulosus	tubulin subunit beta	0.0192	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.172	0.172
Echinococcus multilocularis	neuropeptide receptor	0.004	0.172	0.172
Echinococcus granulosus	Tubulin beta 2C chain	0.0192	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.004	0.172	0.172
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.172	0.172
Onchocerca volvulus		0.004	0.172	0.5
Schistosoma mansoni	myosin xvIII	0.004	0.172	0.172
Schistosoma mansoni	adenoreceptor	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Schistosoma mansoni	amine GPCR	0.004	0.172	0.172
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.004	0.172	0.172
Giardia lamblia	Beta tubulin	0.0192	1	0.5
Brugia malayi	hypothetical protein	0.004	0.172	0.172
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.004	0.172	0.172
Loa Loa (eye worm)	G-protein coupled receptor	0.004	0.172	0.172
Schistosoma mansoni	opsin-like receptor	0.004	0.172	0.172
Trypanosoma cruzi	beta tubulin, putative	0.0192	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.172	0.172
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.004	0.172	0.172
Echinococcus granulosus	tachykinin peptides receptor 99D	0.004	0.172	0.172
Echinococcus granulosus	orexin receptor type 2	0.004	0.172	0.172
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.004	0.172	0.172
Echinococcus multilocularis	allatostatin A receptor	0.004	0.172	0.172
Schistosoma mansoni	biogenic amine (5HT) receptor	0.004	0.172	0.172
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.004	0.172	0.172
Echinococcus multilocularis	tubulin beta 1 chain	0.0192	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.1954	0.1954
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.004	0.172	0.172
Onchocerca volvulus		0.004	0.172	0.5
Echinococcus multilocularis	g-protein coupled receptor	0.004	0.172	0.172
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.004	0.172	0.172
Entamoeba histolytica	tubulin family protein	0.0192	1	0.5
Loa Loa (eye worm)	BEN-1 protein	0.0192	1	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.004	0.172	0.172
Echinococcus granulosus	neuropeptide receptor A26	0.004	0.172	0.172
Leishmania major	beta tubulin	0.0192	1	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.004	0.172	0.172
Onchocerca volvulus		0.004	0.172	0.5
Trichomonas vaginalis	tubulin alpha chain, putative	0.0192	1	1
Brugia malayi	G-protein coupled receptor	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Onchocerca volvulus	Neuropeptide F receptor homolog	0.004	0.172	0.5
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.004	0.172	0.172
Brugia malayi	follicle stimulating hormone receptor	0.004	0.172	0.172
Echinococcus granulosus	g protein coupled receptor	0.004	0.172	0.172
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.172	0.172
Brugia malayi	G protein-coupled receptor	0.004	0.172	0.172
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.172	0.172
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.172	0.172
Loa Loa (eye worm)	G-protein coupled receptor	0.004	0.172	0.172
Onchocerca volvulus		0.004	0.172	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Toxoplasma gondii	beta tubulin	0.0192	1	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.2178	0.2178
Echinococcus granulosus	neuropeptide receptor	0.004	0.172	0.172
Leishmania major	beta tubulin	0.0192	1	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Echinococcus multilocularis	sex peptide receptor	0.004	0.172	0.172
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.004	0.172	0.172
Loa Loa (eye worm)	tubulin beta-4 chain	0.0192	1	1
Brugia malayi	beta-tubulin, identical	0.0192	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.004	0.172	0.172
Onchocerca volvulus		0.004	0.172	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Echinococcus multilocularis	serotonin receptor	0.004	0.172	0.172
Schistosoma mansoni	tubulin subunit beta	0.0192	1	1
Onchocerca volvulus		0.004	0.172	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.172	0.172
Echinococcus granulosus	tm gpcr rhodopsin	0.004	0.172	0.172
Trichomonas vaginalis	tubulin gamma chain, putative	0.0192	1	1
Echinococcus granulosus	neuropeptide s receptor	0.004	0.172	0.172
Echinococcus granulosus	beta tubulin	0.0192	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Brugia malayi	neuropeptide F receptor	0.004	0.172	0.172
Schistosoma mansoni	alpha-1 adrenergic receptor	0.004	0.172	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.172	0.172
Echinococcus granulosus	tubulin beta 4A class IVa	0.0192	1	1
Brugia malayi	hypothetical protein	0.004	0.172	0.172
Onchocerca volvulus		0.004	0.172	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.12 uM	Antiproliferative activity against CSF-1-stimulated mouse 3T3 cells expressing CSF1R	ChEMBL.	23842474
IC50 (binding)	= 9 uM	Inhibition of human ERG	ChEMBL.	23842474
IC50 (binding)	> 30 uM	Inhibition of human Nav1.5	ChEMBL.	23842474
Inhibition (binding)	= 13 %	Inhibition of adrenergic alpha2A receptor (unknown origin) at 10 uM	ChEMBL.	23842474
Inhibition (binding)	= 15 %	Inhibition of adrenergic alpha1A receptor (unknown origin) at 10 uM	ChEMBL.	23842474
Inhibition (binding)	= 48 %	Inhibition of adrenergic alpha1D receptor (unknown origin) at 10 uM	ChEMBL.	23842474

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Mus musculus	ChEMBL23	23842474

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2409311

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1767448