TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 327.285 | Formula: C12H8F3N5OS
H donors: 2 H acceptors: 3 LogP: 2.73 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: S=c1[nH]c2nc(nn2c(=O)[nH]1)Cc1ccc(cc1)C(F)(F)F
InChi: 1S/C12H8F3N5OS/c13-12(14,15)7-3-1-6(2-4-7)5-8-16-9-17-10(22)18-11(21)20(9)19-8/h1-4H,5H2,(H2,16,17,18,19,21,22)
InChiKey: LJGZJDXOSAPGNP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	thymidine phosphorylase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)	Get druggable targets OG5_131632	All targets in OG5_131632
Echinococcus granulosus	thymidine phosphorylase	Get druggable targets OG5_131632	All targets in OG5_131632
Mycobacterium ulcerans	thymidine phosphorylase	Get druggable targets OG5_131632	All targets in OG5_131632
Echinococcus multilocularis	thymidine phosphorylase	Get druggable targets OG5_131632	All targets in OG5_131632

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	dro:myosuppressin receptor	0.0372	0.4601	0.4544
Echinococcus granulosus	rhodopsin orphan GPCR	0.0372	0.4601	0.4544
Brugia malayi	neuropeptide F receptor	0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0586	0.1273
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0372	0.4601	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.177	0.6365
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0372	0.4601	0.4544
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0372	0.4601	1
Brugia malayi	Melatonin receptor type 1A	0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0372	0.4601	0.4544
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.01	0.0873	0.0776
Brugia malayi	Dopamine receptor	0.0372	0.4601	1
Schistosoma mansoni	amine GPCR	0.0372	0.4601	1
Brugia malayi	Serotonin receptor	0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0372	0.4601	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0182	0.0396
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0372	0.4601	0.4544
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0239	0.278	1
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0734	0.9568	0.9564
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0372	0.4601	0.4544
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0372	0.4601	0.4544
Echinococcus multilocularis	g-protein coupled receptor	0.0372	0.4601	0.4544
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0372	0.4601	0.4544
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0372	0.4601	0.4544
Mycobacterium tuberculosis	Probable anthranilate phosphoribosyltransferase TrpD	0.0216	0.2467	0.2388
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Brugia malayi	hypothetical protein	0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0239	0.278	1
Schistosoma mansoni	biogenic amine receptor	0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Echinococcus multilocularis	serotonin receptor	0.0372	0.4601	0.4544
Echinococcus multilocularis	fmrfamide receptor	0.0372	0.4601	0.4544
Leishmania major	trypanothione reductase	0.0044	0.0104	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0372	0.4601	0.4544
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Schistosoma mansoni	chromobox protein	0.0064	0.0388	0.0466
Onchocerca volvulus		0.0372	0.4601	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0111	0.1025	0.0931
Echinococcus granulosus	rhodopsin orphan GPCR	0.0372	0.4601	0.4544
Schistosoma mansoni	amine GPCR	0.0372	0.4601	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0159	0.1681	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0372	0.4601	0.4544
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Schistosoma mansoni	biogenic amine receptor	0.0372	0.4601	1
Brugia malayi	GnHR receptor homolog	0.0372	0.4601	1
Schistosoma mansoni	hypothetical protein	0.0372	0.4601	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0372	0.4601	1
Onchocerca volvulus		0.0372	0.4601	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0159	0.1681	0.6045
Echinococcus multilocularis	serotonin receptor	0.0372	0.4601	0.4544
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0372	0.4601	0.4544
Onchocerca volvulus		0.0372	0.4601	1
Onchocerca volvulus		0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Brugia malayi	hypothetical protein	0.0372	0.4601	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0157	0.1654	0.5949
Schistosoma mansoni	neuropeptide f receptor 76f	0.0372	0.4601	1
Echinococcus granulosus	survival motor neuron protein 1	0.0242	0.2827	0.2751
Trichomonas vaginalis	chromobox protein, putative	0.0064	0.0388	0.1397
Trichomonas vaginalis	glucosylceramidase, putative	0.0157	0.1654	0.5949
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Onchocerca volvulus		0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0372	0.4601	1
Echinococcus multilocularis	chromobox protein 1	0.0064	0.0388	0.0287
Brugia malayi	G-protein coupled receptor	0.0372	0.4601	1
Brugia malayi	neuropeptide F receptor	0.0372	0.4601	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0372	0.4601	0.4544
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0372	0.4601	0.4544
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0111	0.1025	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Brugia malayi	follicle stimulating hormone receptor	0.0372	0.4601	1
Echinococcus granulosus	g protein coupled receptor	0.0372	0.4601	0.4544
Trypanosoma brucei	trypanothione reductase	0.0044	0.0104	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.0372	0.4601	1
Echinococcus multilocularis	g protein coupled receptor	0.0372	0.4601	0.4544
Echinococcus multilocularis	somatostatin receptor	0.0372	0.4601	0.4544
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.01	0.0873	0.0776
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0372	0.4601	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0372	0.4601	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0372	0.4601	0.4544
Brugia malayi	putative neuropeptide receptor	0.0372	0.4601	1
Onchocerca volvulus		0.0372	0.4601	1
Schistosoma mansoni	hypothetical protein	0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Brugia malayi	RE15519p	0.0372	0.4601	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0372	0.4601	0.4544
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.01	0.0873	0.0776
Echinococcus multilocularis	sex peptide receptor	0.0372	0.4601	0.4544
Brugia malayi	Thioredoxin reductase	0.0044	0.0104	0.0227
Echinococcus multilocularis	neuropeptides capa receptor	0.0372	0.4601	0.4544
Echinococcus multilocularis	thymidine phosphorylase	0.0765	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0372	0.4601	0.4544
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Echinococcus multilocularis	geminin	0.0325	0.3955	0.3892
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0111	0.1025	0.0931
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0159	0.1681	0.6045
Schistosoma mansoni	opsin-like receptor	0.0372	0.4601	1
Schistosoma mansoni	neuropeptide receptor	0.0372	0.4601	1
Onchocerca volvulus		0.0372	0.4601	1
Brugia malayi	hypothetical protein	0.0372	0.4601	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0372	0.4601	1
Mycobacterium leprae	Probable anthranilate phosphoribosyltransferase TrpD	0.0216	0.2467	0.1834
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Toxoplasma gondii	thioredoxin reductase	0.0044	0.0104	0.5
Brugia malayi	Dopamine receptor protein 1	0.0372	0.4601	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0372	0.4601	1
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0734	0.9568	0.9427
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0372	0.4601	0.4544
Echinococcus granulosus	neuropeptides capa receptor	0.0372	0.4601	0.4544
Loa Loa (eye worm)	TYRA-2 protein	0.0372	0.4601	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0372	0.4601	1
Echinococcus granulosus	allatostatin A receptor	0.0372	0.4601	0.4544
Mycobacterium tuberculosis	Probable reductase	0.01	0.0873	0.0776
Onchocerca volvulus		0.0372	0.4601	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0372	0.4601	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0372	0.4601	0.4544
Echinococcus granulosus	muscleblind protein	0.0148	0.1539	0.1449
Brugia malayi	hypothetical protein	0.0372	0.4601	1
Echinococcus granulosus	chromobox protein 1	0.0064	0.0388	0.0287
Trichomonas vaginalis	chromobox protein, putative	0.0039	0.0038	0.0135
Echinococcus granulosus	chromobox protein 1	0.0064	0.0388	0.0287
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0159	0.1681	0.6045
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Plasmodium falciparum	thioredoxin reductase	0.0044	0.0104	0.5
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Brugia malayi	Muscleblind-like protein	0.0148	0.1539	0.3344
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0372	0.4601	0.4544
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0372	0.4601	1
Brugia malayi	Serotonin receptor	0.0372	0.4601	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0372	0.4601	1
Echinococcus granulosus	neuropeptide receptor	0.0372	0.4601	0.4544
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Brugia malayi	glutathione reductase	0.0044	0.0104	0.0227
Loa Loa (eye worm)	thioredoxin reductase	0.0044	0.0104	0.0227
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0372	0.4601	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0372	0.4601	0.4544
Echinococcus multilocularis	neuropeptide receptor A26	0.0372	0.4601	0.4544
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0159	0.1681	0.6045
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0242	0.2827	0.6143
Onchocerca volvulus		0.0372	0.4601	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0372	0.4601	1
Schistosoma mansoni	neuropeptide receptor	0.0372	0.4601	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0159	0.1681	0.6045
Echinococcus granulosus	hypothetical protein	0.0372	0.4601	0.4544
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Echinococcus granulosus	neuropeptide s receptor	0.0372	0.4601	0.4544
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0372	0.4601	0.4544
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Plasmodium vivax	thioredoxin reductase, putative	0.0044	0.0104	0.5
Brugia malayi	hypothetical protein	0.0372	0.4601	1
Brugia malayi	hypothetical protein	0.0242	0.2827	0.6143
Trypanosoma cruzi	trypanothione reductase, putative	0.0044	0.0104	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0372	0.4601	0.4544
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0372	0.4601	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0372	0.4601	0.4544
Echinococcus granulosus	neuropeptides capa receptor	0.0372	0.4601	0.4544
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0372	0.4601	0.4544
Onchocerca volvulus		0.0049	0.0182	0.0396
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0372	0.4601	1
Schistosoma mansoni	myosin xvIII	0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0372	0.4601	0.4544
Brugia malayi	hypothetical protein	0.0372	0.4601	1
Echinococcus multilocularis	expressed protein	0.0371	0.4587	0.453
Echinococcus granulosus	serotonin receptor	0.0372	0.4601	0.4544
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0372	0.4601	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0111	0.1025	0.0931
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0372	0.4601	0.4544
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0372	0.4601	1
Loa Loa (eye worm)	glutathione reductase	0.0044	0.0104	0.0227
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0372	0.4601	0.4544
Treponema pallidum	fructose-bisphosphate aldolase	0.0159	0.1681	0.5
Brugia malayi	hypothetical protein	0.0372	0.4601	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0372	0.4601	0.4544
Echinococcus granulosus	G protein coupled receptor 139	0.0372	0.4601	0.4544
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Echinococcus granulosus	g protein coupled receptor	0.0372	0.4601	0.4544
Brugia malayi	hypothetical protein	0.0372	0.4601	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0159	0.1681	0.6045
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0372	0.4601	0.4544
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0372	0.4601	0.4544
Schistosoma mansoni	neuropeptide receptor	0.0372	0.4601	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.01	0.0873	0.0776
Echinococcus multilocularis	neuropeptide s receptor	0.0372	0.4601	0.4544
Trichomonas vaginalis	glucosylceramidase, putative	0.0239	0.278	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0372	0.4601	1
Echinococcus granulosus	g-protein coupled receptor	0.0372	0.4601	0.4544
Schistosoma mansoni	neuropeptide receptor	0.0372	0.4601	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0372	0.4601	0.4544
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0372	0.4601	1
Onchocerca volvulus		0.0372	0.4601	1
Brugia malayi	larval opioid receptor	0.0372	0.4601	1
Echinococcus granulosus	geminin	0.0325	0.3955	0.3892
Schistosoma mansoni	neuropeptide F-like receptor	0.0372	0.4601	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0372	0.4601	0.4544
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0372	0.4601	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0372	0.4601	1
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0239	0.278	0.6042
Echinococcus granulosus	tm gpcr rhodopsin	0.0372	0.4601	0.4544
Brugia malayi	putative neuropeptide receptor NPR1	0.0372	0.4601	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0372	0.4601	0.4544
Onchocerca volvulus		0.0372	0.4601	1
Schistosoma mansoni	opsin-like receptor	0.0372	0.4601	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0372	0.4601	0.4544
Echinococcus multilocularis	chromobox protein 1	0.0064	0.0388	0.0287
Schistosoma mansoni	amine GPCR	0.0372	0.4601	1
Echinococcus multilocularis	orexin receptor type 2	0.0372	0.4601	0.4544
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0159	0.1681	0.6045
Echinococcus granulosus	tm gpcr rhodopsin	0.0372	0.4601	0.4544
Echinococcus granulosus	rhodopsin orphan GPCR	0.0372	0.4601	0.4544
Onchocerca volvulus		0.0372	0.4601	1
Onchocerca volvulus	Glucosylceramidase homolog	0.0157	0.1654	0.3594
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0372	0.4601	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0372	0.4601	0.4544
Echinococcus multilocularis	dro:myosuppressin receptor	0.0372	0.4601	0.4544
Echinococcus multilocularis	g protein coupled receptor	0.0372	0.4601	0.4544
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0239	0.278	0.6042
Trichomonas vaginalis	glucosylceramidase, putative	0.0157	0.1654	0.5949
Echinococcus granulosus	7tm_1 domain containing protein	0.0372	0.4601	0.4544
Trichomonas vaginalis	glucosylceramidase, putative	0.0157	0.1654	0.5949
Echinococcus multilocularis	neuropeptide Y receptor	0.0372	0.4601	0.4544
Schistosoma mansoni	neuropeptide F-like receptor	0.0372	0.4601	1
Schistosoma mansoni	adenoreceptor	0.0372	0.4601	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0372	0.4601	0.4544
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0372	0.4601	1
Echinococcus multilocularis	neuropeptide receptor	0.0372	0.4601	0.4544
Onchocerca volvulus		0.0372	0.4601	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0372	0.4601	0.4544
Brugia malayi	Heterochromatin protein 1	0.0064	0.0388	0.0844
Schistosoma mansoni	hypothetical protein	0.0325	0.3955	0.8539
Trichomonas vaginalis	glucosylceramidase, putative	0.0239	0.278	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0372	0.4601	0.4544
Echinococcus granulosus	somatostatin receptor	0.0372	0.4601	0.4544
Trichomonas vaginalis	glucosylceramidase, putative	0.0157	0.1654	0.5949
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0372	0.4601	0.4544
Schistosoma mansoni	chromobox protein	0.0064	0.0388	0.0466
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0039	0.0038	0.0082
Echinococcus granulosus	rhodopsin orphan GPCR	0.0372	0.4601	0.4544
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0372	0.4601	1
Echinococcus granulosus	fmrfamide receptor	0.0372	0.4601	0.4544
Brugia malayi	hypothetical protein	0.0372	0.4601	1
Loa Loa (eye worm)	heterochromatin protein 1	0.0064	0.0388	0.0844
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.01	0.0873	0.0776
Echinococcus granulosus	sex peptide receptor	0.0372	0.4601	0.4544
Echinococcus granulosus	expressed protein	0.0371	0.4587	0.453
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0372	0.4601	1
Schistosoma mansoni	opsin-like receptor	0.0372	0.4601	1
Echinococcus granulosus	neuropeptide Y receptor	0.0372	0.4601	0.4544
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0734	0.9568	1
Plasmodium falciparum	glutathione reductase	0.0044	0.0104	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0372	0.4601	1
Echinococcus granulosus	orexin receptor type 2	0.0372	0.4601	0.4544
Echinococcus granulosus	neuropeptide FF receptor 2	0.0372	0.4601	0.4544
Onchocerca volvulus		0.0372	0.4601	1
Mycobacterium ulcerans	thymidine phosphorylase	0.0765	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0372	0.4601	1
Schistosoma mansoni	hypothetical protein	0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0372	0.4601	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0372	0.4601	0.4544
Echinococcus granulosus	neuropeptide Y receptor	0.0372	0.4601	0.4544
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0372	0.4601	1
Brugia malayi	G protein-coupled receptor	0.0372	0.4601	1
Schistosoma mansoni	amine GPCR	0.0372	0.4601	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0157	0.1654	0.5949
Onchocerca volvulus		0.0372	0.4601	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1539	0.3344
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0159	0.1681	0.6045
Echinococcus multilocularis	g protein coupled receptor	0.0372	0.4601	0.4544
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0372	0.4601	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0372	0.4601	1
Brugia malayi	ORL1-like opioid receptor	0.0372	0.4601	1
Schistosoma mansoni	biogenic amine receptor	0.0372	0.4601	1
Schistosoma mansoni	histamine h1 receptor	0.0372	0.4601	1
Plasmodium vivax	glutathione reductase, putative	0.0044	0.0104	0.5
Onchocerca volvulus		0.0372	0.4601	1
Echinococcus granulosus	neuropeptide receptor A26	0.0372	0.4601	0.4544
Brugia malayi	G protein-coupled receptor F59B2.13	0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0372	0.4601	0.4544
Brugia malayi	sulfakinin receptor protein	0.0372	0.4601	1
Schistosoma mansoni	amine GPCR	0.0372	0.4601	1
Brugia malayi	hypothetical protein	0.0372	0.4601	1
Giardia lamblia	Fructose-bisphosphate aldolase	0.0159	0.1681	0.5
Echinococcus granulosus	7TM GPCR rhodopsin	0.0372	0.4601	0.4544
Brugia malayi	Dopamine receptor protein 2	0.0372	0.4601	1
Echinococcus multilocularis	muscleblind protein 1	0.0148	0.1539	0.1449
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0372	0.4601	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0372	0.4601	0.4544
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0239	0.278	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0239	0.278	1
Trichomonas vaginalis	chromobox protein, putative	0.0039	0.0038	0.0135
Brugia malayi	AKH receptor	0.0372	0.4601	1
Echinococcus multilocularis	allatostatin A receptor	0.0372	0.4601	0.4544
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1539	0.3344
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0372	0.4601	0.4544
Loa Loa (eye worm)	neuropeptide F receptor	0.0372	0.4601	1
Schistosoma mansoni	hypothetical protein	0.0372	0.4601	1
Echinococcus multilocularis	neuropeptide receptor	0.0372	0.4601	0.4544
Trichomonas vaginalis	glucosylceramidase, putative	0.0157	0.1654	0.5949
Schistosoma mansoni	hypothetical protein	0.0325	0.3955	0.8539
Echinococcus multilocularis	muscleblind protein	0.0148	0.1539	0.1449
Mycobacterium tuberculosis	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)	0.0765	1	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0242	0.2827	0.2751
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0372	0.4601	0.4544
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0159	0.1681	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0372	0.4601	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0372	0.4601	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.4601	1
Echinococcus granulosus	g protein coupled receptor	0.0372	0.4601	0.4544
Brugia malayi	G-protein coupled receptor	0.0372	0.4601	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.177	0.6365
Onchocerca volvulus		0.0372	0.4601	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0372	0.4601	1
Trichomonas vaginalis	chromobox protein, putative	0.0064	0.0388	0.1397
Echinococcus granulosus	neuropeptide receptor	0.0372	0.4601	0.4544

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 9.92 uM	Inhibition of human recombinant thymidine phosphorylase expressed in Escherichia coli using thymidine as substrate after 4 to 20 mins by spectrophotometry	ChEMBL.	23871912

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2418077

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1767592