TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 631.684 | Formula: C36H36F3N3O4
H donors: 1 H acceptors: 2 LogP: 7.81 Rotable bonds: 15
Rule of 5 violations (Lipinski): 2
SMILES: CCCCOc1ccc(cc1)c1nc2c(n1CCc1ccc(c(c1)OC)OC)ccc(c2)C(=O)NCc1ccc(cc1)C(F)(F)F
InChi: 1S/C36H36F3N3O4/c1-4-5-20-46-29-14-9-26(10-15-29)34-41-30-22-27(35(43)40-23-25-6-12-28(13-7-25)36(37,38)39)11-16-31(30)42(34)19-18-24-8-17-32(44-2)33(21-24)45-3/h6-17,21-22H,4-5,18-20,23H2,1-3H3,(H,40,43)
InChiKey: KGAOISJYLJCIFD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0045	0.1492	0.0973
Echinococcus multilocularis	chromobox protein 1	0.007	0.2884	0.5836
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0095	0.4264	0.4067
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1492	0.1492
Brugia malayi	nuclear receptor RXR	0.0045	0.1492	0.1199
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0095	0.4264	0.4067
Onchocerca volvulus		0.0045	0.1492	0.2949
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1492	0.1492
Schistosoma mansoni	nuclear hormone receptor	0.0095	0.4264	0.5945
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0095	0.4264	0.5945
Schistosoma mansoni	nuclear hormone receptor	0.0045	0.1492	0.0973
Brugia malayi	ecdysteroid receptor	0.0095	0.4264	0.4067
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0063	0.2492	0.4654
Brugia malayi	latrophilin 2 splice variant baaae	0.0135	0.6525	0.6405
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0333	1
Schistosoma mansoni	nuclear receptor	0.0045	0.1492	0.0973
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0198	1	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.1789	0.1789
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1492	0.1492
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.1349	0.3419
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0095	0.4264	0.5945
Echinococcus granulosus	thyroid hormone receptor alpha	0.0045	0.1492	0.1637
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0333	0.0333
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0095	0.4264	0.4264
Schistosoma mansoni	hypothetical protein	0.0063	0.2492	0.2767
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0095	0.4264	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1492	0.1492
Brugia malayi	hypothetical protein	0.0035	0.0949	0.0638
Brugia malayi	hypothetical protein	0.005	0.1789	0.1506
Brugia malayi	Nuclear hormone receptor E75	0.0045	0.1492	0.1199
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0095	0.4264	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0949	0.196
Brugia malayi	Nuclear hormone receptor-like 1	0.005	0.1789	0.1506
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0045	0.1492	0.0973
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.005	0.1789	0.1505
Schistosoma mansoni	hypothetical protein	0.0063	0.2492	0.2767
Brugia malayi	steroid hormone receptor	0.0095	0.4264	0.4067
Trichomonas vaginalis	chromobox protein, putative	0.007	0.2884	1
Onchocerca volvulus		0.0095	0.4264	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0095	0.4264	0.4067
Loa Loa (eye worm)	hypothetical protein	0.0095	0.4264	0.4264
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.1556	0.1556
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.1556	0.1265
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0095	0.4264	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0095	0.4264	0.4264
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.1556	0.1087
Brugia malayi	Nuclear hormone receptor-like 1	0.0095	0.4264	0.4067
Brugia malayi	Steroid receptor seven-up type 2	0.0095	0.4264	0.4067
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0095	0.4264	0.5945
Schistosoma mansoni	nuclear hormone receptor	0.0045	0.1492	0.0973
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0095	0.4264	0.5945
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0198	1	1
Onchocerca volvulus		0.0031	0.0716	0.0975
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0333	0.5
Brugia malayi	tailless protein	0.0045	0.1492	0.1199
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0095	0.4264	1
Brugia malayi	hypothetical protein	0.0045	0.1492	0.1199
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0333	0.5
Loa Loa (eye worm)	hypothetical protein	0.0095	0.4264	0.4264
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0095	0.4264	0.4067
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0095	0.4264	1
Brugia malayi	Nuclear hormone receptor E75	0.0045	0.1492	0.1199
Echinococcus granulosus	chromobox protein 1	0.007	0.2884	0.5836
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0095	0.4264	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.1789	0.1789
Entamoeba histolytica	hypothetical protein	0.0035	0.0949	0.196
Loa Loa (eye worm)	hypothetical protein	0.0095	0.4264	0.4264
Echinococcus multilocularis	chromobox protein 1	0.007	0.2884	0.5836
Onchocerca volvulus		0.0045	0.1492	0.2949
Echinococcus multilocularis	nuclear receptor nhr 48	0.0045	0.1492	0.1637
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0063	0.2492	0.2234
Schistosoma mansoni	retinoic acid receptor RXR	0.0095	0.4264	0.5945
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0095	0.4264	1
Schistosoma mansoni	nuclear receptor	0.0045	0.1492	0.0973
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0095	0.4264	0.4264
Loa Loa (eye worm)	hypothetical protein	0.005	0.1789	0.1789
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0095	0.4264	0.4067
Brugia malayi	conserved hypotetical protein	0.0045	0.1492	0.1199
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.1349	0.3419
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1492	0.1492
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1492	0.1492
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.1556	0.1087
Schistosoma mansoni	zinc finger protein	0.0045	0.1492	0.0973
Schistosoma mansoni	thyroid hormone receptor	0.0095	0.4264	0.5945
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0333	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.1789	0.1789
Schistosoma mansoni	chromobox protein	0.007	0.2884	0.347
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0333	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0095	0.4264	0.4264
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0333	0.5
Loa Loa (eye worm)	hypothetical protein	0.0063	0.2492	0.2492
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0095	0.4264	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0333	0.0333
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0333	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0045	0.1492	0.1199
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0045	0.1492	0.1637
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.1349	0.2585
Brugia malayi	nuclear receptor NHR-88	0.0095	0.4264	0.4067
Schistosoma mansoni	thyroid hormone receptor	0.0095	0.4264	0.5945
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1492	0.1492
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0333	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0095	0.4264	0.4067
Brugia malayi	hypothetical protein	0.0045	0.1492	0.1199
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.005	0.1789	0.1505
Brugia malayi	Heterochromatin protein 1	0.007	0.2884	0.2639
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0716	0.0716
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0095	0.4264	0.5945
Brugia malayi	nuclear hormone receptor	0.0095	0.4264	0.4067
Loa Loa (eye worm)	hypothetical protein	0.0135	0.6525	0.6525
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0333	0.5
Brugia malayi	nuclear hormone receptor	0.0045	0.1492	0.1199
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0045	0.1492	0.1637
Echinococcus granulosus	FTZ F1 alpha	0.0095	0.4264	1
Schistosoma mansoni	hypothetical protein	0.0135	0.6525	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0045	0.1492	0.1637
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0095	0.4264	0.4264
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0095	0.4264	0.4067
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0045	0.1492	0.1199
Brugia malayi	nuclear receptor NHR-67	0.0045	0.1492	0.1199
Echinococcus granulosus	GPCR family 2	0.0063	0.2492	0.4654
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0095	0.4264	0.4067
Loa Loa (eye worm)	hypothetical protein	0.0095	0.4264	0.4264
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0095	0.4264	0.4067
Schistosoma mansoni	hypothetical protein	0.0063	0.2492	0.2767
Onchocerca volvulus	Protein ultraspiracle homolog	0.0095	0.4264	1
Brugia malayi	Nuclear hormone receptor-like 1	0.005	0.1789	0.1506
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.008	0.348	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0095	0.4264	0.4264
Echinococcus multilocularis	ecdysone induced protein 78C	0.0095	0.4264	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0949	0.196
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0333	1
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.008	0.348	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0	0.5
Loa Loa (eye worm)	heterochromatin protein 1	0.007	0.2884	0.2884
Echinococcus multilocularis	FTZ F1 alpha	0.0095	0.4264	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0063	0.2492	0.4654
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0095	0.4264	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0095	0.4264	0.4264
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.1556	0.1829
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0045	0.1492	0.2949
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0095	0.4264	1
Brugia malayi	nuclear receptor RXR	0.005	0.1789	0.1506
Entamoeba histolytica	hypothetical protein	0.0035	0.0949	0.196
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1492	0.1492
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0045	0.1492	0.1637
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0045	0.1492	0.2949
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0095	0.4264	0.4067
Schistosoma mansoni	nuclear receptor nhr-48	0.0045	0.1492	0.0973
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0333	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.4264	0.4264
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1492	0.1492
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0095	0.4264	1
Brugia malayi	chromobox protein homolog 3	0.0039	0.1184	0.0881
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.1556	0.1829
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0045	0.1492	0.1637
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0039	0.1184	0.2167
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0095	0.4264	0.4067
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0095	0.4264	0.4067
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1492	0.1492
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0095	0.4264	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0045	0.1492	0.1637
Onchocerca volvulus	Bile acid receptor homolog	0.0095	0.4264	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0333	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.1556	0.1829
Schistosoma mansoni	hypothetical protein	0.0063	0.2492	0.2767
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0333	0.0333
Echinococcus multilocularis	GPCR, family 2	0.0063	0.2492	0.4654
Echinococcus granulosus	ecdysone induced protein 78C	0.0095	0.4264	1
Schistosoma mansoni	coup transcription factor	0.0095	0.4264	0.5945
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0045	0.1492	0.1492
Brugia malayi	Latrophilin receptor protein 2	0.0063	0.2492	0.2234
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0095	0.4264	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0063	0.2492	0.4654
Loa Loa (eye worm)	nuclear hormone receptor	0.0045	0.1492	0.1492
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0045	0.1492	0.1492
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0333	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0095	0.4264	0.4264
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0045	0.1492	0.1637
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.1556	0.1829
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1492	0.1492
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0095	0.4264	0.5945
Trichomonas vaginalis	chromobox protein, putative	0.007	0.2884	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0045	0.1492	0.1637
Loa Loa (eye worm)	hypothetical protein	0.008	0.348	0.348
Brugia malayi	nuclear hormone receptor family member odr-7	0.0045	0.1492	0.1199
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0045	0.1492	0.1637
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1492	0.1492
Brugia malayi	ecdysone receptor	0.0045	0.1492	0.1199
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.1184	0.2714
Brugia malayi	nuclear receptor NHR-88	0.0045	0.1492	0.1199
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0333	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.4264	0.4264
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0063	0.2492	0.2492
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0095	0.4264	0.5945
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.1184	0.2714
Brugia malayi	photoreceptor-specific nuclear receptor	0.0095	0.4264	0.4067
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0095	0.4264	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0	0.5
Loa Loa (eye worm)	DR-78	0.0045	0.1492	0.1492
Echinococcus granulosus	chromobox protein 1	0.007	0.2884	0.5836
Loa Loa (eye worm)	hypothetical protein	0.005	0.1789	0.1789
Echinococcus granulosus	nuclear receptor nhr 48	0.0045	0.1492	0.1637
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.005	0.1789	0.2532
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0063	0.2492	0.4654
Brugia malayi	hypothetical protein	0.005	0.1789	0.1506
Schistosoma mansoni	chromobox protein	0.007	0.2884	0.347
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0095	0.4264	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0333	1
Loa Loa (eye worm)	hypothetical protein	0.0198	1	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.4264	0.4264
Schistosoma mansoni	RAR-like nuclear receptor	0.0095	0.4264	0.5945
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0095	0.4264	0.4067
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.005	0.1789	0.2532
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.005	0.1789	0.1789
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0045	0.1492	0.1199
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1492	0.1492
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1184	0.1184
Loa Loa (eye worm)	steroid hormone receptor	0.0095	0.4264	0.4264
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.1556	0.1087

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 30 %	Inhibition of C-terminal FLAG-tagged human recombinant autotaxin using synthetic substrate FS-3 at 10 uM measured every 2 mins by FRET assay relative to control	ChEMBL.	23816044

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2418705

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1767856