Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 3 % | Inhibition of p38alpha (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Inhibition (binding) | = 6 % | Inhibition of INSR (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Inhibition (binding) | = 17 % | Inhibition of MET (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Inhibition (binding) | = 21 % | Inhibition of CK1delta (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Inhibition (binding) | = 38 % | Inhibition of ERK2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Inhibition (binding) | = 39 % | Inhibition of GSK3beta (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Inhibition (binding) | = 39 % | Inhibition of ERK1 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Inhibition (binding) | = 41 % | Inhibition of MAPKAPK5 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Inhibition (binding) | = 59 % | Inhibition of AURA (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Inhibition (binding) | = 61 % | Inhibition of SRC (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Inhibition (binding) | = 64 % | Inhibition of CHK2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Inhibition (binding) | = 65 % | Inhibition of LYN (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Inhibition (binding) | = 66 % | Inhibition of MK2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Inhibition (binding) | = 70 % | Inhibition of AKT2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Inhibition (binding) | = 77 % | Inhibition of RSK1 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Inhibition (binding) | = 80 % | Inhibition of ABL (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Inhibition (binding) | = 80 % | Inhibition of PKD2 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Inhibition (binding) | = 84 % | Inhibition of CHK1 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Inhibition (binding) | = 84 % | Inhibition of FYN (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Inhibition (binding) | = 86 % | Inhibition of LCK (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Inhibition (binding) | = 94 % | Inhibition of MSK1 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Inhibition (binding) | = 94 % | Inhibition of AKT1 (unknown origin) at 30 uM by microfluidic mobility shift assay relative to control | ChEMBL. | 23920481 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.