Detailed view for Smp_069160.2

Basic information

TDR Targets ID: 289271
Schistosoma mansoni, peptidyl-prolyl cis-trans isomerase G ppig
Source Database / ID:  GeneDB

pI: 11.21 | Length (AA): 1215 | MW (Da): 136203 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00160   Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

Gene Ontology

Mouse over links to read term descriptions.
GO:0000413   protein peptidyl-prolyl isomerization  
GO:0003755   peptidyl-prolyl cis-trans isomerase activity  
GO:0006457   protein folding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 191 4fru (A) 7 183 47.00 0 1 0.742333 -0.86
7 179 5yba (A) 4 172 56.00 0 1 0.934787 -1.64
7 179 2wfi (A) 7 177 62.00 0 1 1.00079 -1.6
8 179 2he9 (A) 7 176 59.00 0 1 0.977164 -1.64
231 322 1ix5 (A) 5 92 14.00 0.063 0.02 0.0253202 0.44
253 301 1u79 (A) 30 78 10.00 0.69 0 0.236929 -1.05
1113 1211 6d0t (A) 12 110 14.00 0 0.01 0.190781 -0.63

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130173)

Species Accession Gene Product
Arabidopsis thaliana AT3G63400   cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein
Arabidopsis thaliana AT4G32420   cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein
Caenorhabditis elegans CELE_D1009.2   Protein CYN-8, isoform A
Dictyostelium discoideum DDB_G0279491   hypothetical protein
Drosophila melanogaster Dmel_CG1866   CG1866 gene product from transcript CG1866-RC
Echinococcus granulosus EgrG_001194300   peptidyl prolyl isomerase G
Echinococcus multilocularis EmuJ_001194300   peptidyl prolyl isomerase G
Homo sapiens ENSG00000114857   natural killer cell triggering receptor
Homo sapiens ENSG00000138398   peptidylprolyl isomerase G (cyclophilin G)
Mus musculus ENSMUSG00000032525   natural killer tumor recognition sequence
Mus musculus ENSMUSG00000042133   peptidyl-prolyl isomerase G (cyclophilin G)
Schistosoma japonicum Sjp_0303590   expressed protein
Schistosoma japonicum Sjp_0013430   ko:K09566 peptidyl-prolyl isomerase G (cyclophilin G), putative
Schistosoma mansoni Smp_069160.1   peptidyl-prolyl cis-trans isomerase G ppig
Schistosoma mansoni Smp_069160.2   peptidyl-prolyl cis-trans isomerase G ppig
Trichomonas vaginalis TVAG_277390   peptidyl-prolyl cis-trans isomerase A, ppia, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens peptidylprolyl isomerase G (cyclophilin G) Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Cyclophilin A 164 aa 50.3% 169 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0126 1 0.5
0.0126 1 0.5
0.0127 1 1
0.011 1 1
0.055 1 1
0.0126 1 0.5
0.0354 1 1
0.0224 0.553 0.553
0.0104 1 0.5
0.0328 1 1
0.0127 1 1
0.0127 1 1
0.0339 1 0.5
0.0126 1 0.5
0.0453 0.6702 1
0.0126 1 0.5
0.0126 1 1
0.0127 1 1
0.0356 1 1
0.0126 1 1
0.0103 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_069160.2 (Schistosoma mansoni), peptidyl-prolyl cis-trans isomerase G ppig
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