Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0414 | 0.1756 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0411 | 0.172 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0735 | 0.6861 | 0.874 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0411 | 0.172 | 0.9798 |
Echinococcus granulosus | acetylcholinesterase | 0.0414 | 0.1756 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0414 | 0.1756 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.1463 | 0.1863 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.1756 | 0.2237 |
Brugia malayi | Carboxylesterase family protein | 0.0414 | 0.1756 | 0.1756 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0414 | 0.1756 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0414 | 0.1756 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0414 | 0.1756 | 0.2237 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0798 | 0.7851 | 0.7851 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0411 | 0.172 | 0.9798 |
Echinococcus multilocularis | acetylcholinesterase | 0.0414 | 0.1756 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0303 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0411 | 0.172 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0414 | 0.1756 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0798 | 0.7851 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0411 | 0.172 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0414 | 0.1756 | 0.1756 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0414 | 0.1756 | 0.2237 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.1756 | 0.2237 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.0625 ug ml-1 | Antibacterial activity against enterotoxigenic Escherichia coli by disc diffusion method | ChEMBL. | 23933534 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.