Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | choline o-acyltransferase | 0.0105 | 0.0211 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0384 | 0.2384 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0105 | 0.0211 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0105 | 0.0211 | 0.0118 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0222 | 0.1123 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0384 | 0.2384 | 0.5 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0105 | 0.0211 | 0.0118 |
Onchocerca volvulus | 0.0105 | 0.0211 | 1 | |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0222 | 0.1123 | 0.2511 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0384 | 0.2384 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0105 | 0.0211 | 0.0118 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0222 | 0.1123 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0105 | 0.0211 | 0.0312 |
Giardia lamblia | DNA topoisomerase II | 0.0078 | 0 | 0.5 |
Brugia malayi | Choline O-acetyltransferase | 0.0105 | 0.0211 | 0.0118 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.009 | 0.0094 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1364 | 1 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0105 | 0.0211 | 0.0118 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0105 | 0.0211 | 0.0312 |
Onchocerca volvulus | 0.0105 | 0.0211 | 1 | |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.009 | 0.0094 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0572 | 0.3842 | 1 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0105 | 0.0211 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0211 | 0.0118 |
Onchocerca volvulus | 0.0105 | 0.0211 | 1 | |
Echinococcus granulosus | choline O acetyltransferase | 0.0105 | 0.0211 | 0.0312 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0572 | 0.3842 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0384 | 0.2384 | 0.5 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0105 | 0.0211 | 0.0118 |
Onchocerca volvulus | 0.0105 | 0.0211 | 1 | |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0132 | 0.0424 | 0.5 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0384 | 0.2384 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0222 | 0.1123 | 0.2511 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0384 | 0.2384 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0222 | 0.1123 | 0.2511 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0105 | 0.0211 | 0.0118 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0572 | 0.3842 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0384 | 0.2384 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0572 | 0.3842 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0572 | 0.3842 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.25 ug ml-1 | Antibacterial activity against enterotoxigenic Escherichia coli by disc diffusion method | ChEMBL. | 23933534 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.