Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Ovis aries | Major prion protein | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0437 | 0.149 | 0.149 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0437 | 0.149 | 0.149 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2584 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.149 | 0.149 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.149 | 0.149 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.149 | 0.149 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0437 | 0.149 | 0.149 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0437 | 0.149 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0437 | 0.149 | 0.149 |
Brugia malayi | Carboxylesterase family protein | 0.0437 | 0.149 | 0.149 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.149 | 0.149 |
Onchocerca volvulus | 0.0437 | 0.149 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.2584 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.2584 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0437 | 0.149 | 0.149 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2584 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0437 | 0.149 | 0.149 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0437 | 0.149 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0437 | 0.149 | 0.149 |
Onchocerca volvulus | 0.0437 | 0.149 | 1 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0437 | 0.149 | 0.149 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0061 | 0 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0437 | 0.149 | 0.149 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.149 | 0.149 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0437 | 0.149 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0437 | 0.149 | 0.149 |
Onchocerca volvulus | 0.0437 | 0.149 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.149 | 0.149 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2584 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0437 | 0.149 | 0.149 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0437 | 0.149 | 0.149 |
Brugia malayi | Carboxylesterase family protein | 0.0437 | 0.149 | 0.149 |
Loa Loa (eye worm) | hypothetical protein | 0.2584 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0437 | 0.149 | 0.149 |
Echinococcus multilocularis | acetylcholinesterase | 0.2584 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0437 | 0.149 | 0.149 |
Schistosoma mansoni | gliotactin | 0.0437 | 0.149 | 0.149 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0437 | 0.149 | 0.149 |
Echinococcus multilocularis | neuroligin | 0.0437 | 0.149 | 0.149 |
Onchocerca volvulus | 0.0437 | 0.149 | 1 | |
Echinococcus multilocularis | acetylcholinesterase | 0.2584 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2584 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2584 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2584 | 1 | 1 |
Onchocerca volvulus | 0.0437 | 0.149 | 1 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0437 | 0.149 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0437 | 0.149 | 0.149 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0437 | 0.149 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.149 | 0.149 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0437 | 0.149 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0437 | 0.149 | 0.149 |
Echinococcus granulosus | acetylcholinesterase | 0.2584 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0437 | 0.149 | 0.149 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 424 nM | Antiprion activity against sheep prion infected in mouse ScN2a-cl3 cells assessed as reduction in PrPSc level after 5 days by ELISA | ChEMBL. | 23977416 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.